SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff and Chair of Conference |
7:40 pm - 9:30 pm | CHEMISTRY AND BIOLOGY OF RIBONUCLEOTIDE REDUCTASES |
| Discussion Leader: Squire Booker (Penn State) |
7:40 pm - 8:15 pm | J. Martin Bollinger (Penn State)
"Oxygen Activation and Radical Initiation by a Manganese/Iron Cluster in Chlamydia trachomatis Ribonucleotide Reductase" |
8:15 pm - 8:25 pm | Discussion |
8:25 pm - 9:00 pm | Britt-Marie Sjöberg (Stockholm University)
"Ribonucleotide reductases and horizontal gene transfer" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Poster Talk: Lionel Cheruzel (California Institute of Technology)
"Probing enzymes with Ru(II)-diimine sensitizer wires" |
9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | ELECTRON AND PROTON TRANSFER |
| Discussion Leader: Marc Robert (Paris - Diderot) |
9:00 am - 9:35 am | JoAnne Stubbe (MIT)
"Site specific incorporation of 3-Aminotyrosine into R1 and R2. Direct detection of intermediates on the PCET pathway in Ribonucleotide reductases" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Wolfgang Bückel (Philips Universität Marburg)
"Radical formation by energy driven electron transfer" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:35 am | David B. Goodin (Scripps Research Institute)
"Molecular Wires to Probe the Structure and Mechanism of Peroxidases, P450, and Nitric Oxide Synthase" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:20 pm | Michael Sutcliffe (University of Manchester)
"An atomistic picture of quantum tunneling in enzymatic hydrogen transfer reactions" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | RADICAL MECHANISMS - I |
| Discussion Leader: Olafur T. Magnusson (Decode Genetics) |
7:30 pm - 8:05 pm | George Reed (University of Wisconsin)
"The CoA-dependent hydroxyethylidene-thiamin pyrophosphate free radical intermediate in pyruvate:ferredoxin oxidoreductase" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:50 pm | R. David Britt (University of California - Davis)
“Multifrequency EPR Studies of bilin radical intermediates in phytobilin synthesis” |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Poster Talk: Aimin Liu (University of Mississippi Medical Center)
“Tryptophan Oxygenation Mechanisms” |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | QUINONE COFACTORS: BIOSYNTHESIS, MECHANISM, AND MEDICAL IMPLICATIONS |
| Discussion Leader: Minae Mure (University of Kansas) |
9:00 am - 9:35 am | Victor Davidson (University of Mississippi)
"Novel Reaction Intermediates in MauG-dependent Tryptophan Tryptophylquinone Biosynthesis" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Judith Klinman (University of California - Berkeley)
"Oxidative chemistry during TPQ biogenesis and catalysis" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:35 am | Agnes Rötig (INSERM, Paris)
"Coenzyme Q10 biosynthesis deficiency in children" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:00 pm | Poster Talk: Jim Whittaker (Oregon Health and Science University)
"The electronic structure of the Tyr-Cys free radical in galactose oxidase determined by EPR spectroscopy" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Poster Talk: Cindy Chang (Berkeley)
"Structural insights into substrate specificity in copper amine oxidases from Hansenula polymorpha" |
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | CROSS-LINKED AMINO ACID COFACTORS |
| Discussion Leader: Britt-Marie Sjöberg (Stockholm University) |
7:30 pm - 8:05 pm | Robert Gennis (University of Illinois)
"The Cross-linked Histidine-Tyrosine Cofactor at the Active Site of the Heme-Copper Proton Pumping Respiratory Oxidases" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:50 pm | Brian Fox (University of Wisconsin)
"The Structural Genomics Pathway to Cysteine Dioxygenase: Structure then Mechanism" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Poster Talk: Emma Raven (University of Leicester)
“Autocatalytic formation of heme-protein covalent links in a heme peroxidase” |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | RADICAL MECHANISMS - II |
| Discussion Leader: Simon Phillips (Leeds) |
9:00 am - 9:35 am | Ruma Banerjee (University of Michigan)
"Escort and Protector of a Radical B12 Enzyme" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Cecilia Tommos (University of Pennsylvania)
"Exploring amino-acid radicals and quinone redox chemistry in model proteins" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:35 am | Carsten Krebs (Penn State University)
"Oxygen Activation by Mononuclear Non-Heme Enzymes" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:00 pm | Poster Talk: Joshua Woodward (Berkeley)
"The pterin radical as a mechanistic probe of the second step of nitric oxide synthase" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Poster Talk: Marc Robert (Paris - Diderot)
"Concerted proton-coupled electron transfer reactions in biomimetic phenols? Mechanistic insights and modeling from electrochemistry" |
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | COMPLEX REDOX COFACTORS: ASSEMBLY |
| Discussion Leader: John Peters (Montana State University) |
7:30 pm - 8:05 pm | Luis Rubio (University of California - Berkeley)
"Complete synthesis of the iron-molybdenum cofactor of nitrogenase with purified NifB, NifEN, and NifH proteins" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Poster Talk: John Peters (Montana State University)
"A specific role for HydF in [FeFe]-hydrogenase H-Cluster Biosynthesis" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Poster Talk: Joseph Jarrett (University of Hawaii)
"Iron-sulfur cluster assembly in an AdoMet radical enzyme: Interaction of biotin synthase with the ISC system in E. coli" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:25 pm | Poster Talk: Annemarie Wait (Oxford University)
"Challenges for electrocatalytic oxidation of H2 in air at a [NiFe]-hydrogenase active site" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | COMPLEX REDOX COFACTORS: MECHANISM |
| Discussion Leader: Steve Colbran (New South Wales) |
9:00 am - 9:35 am | Lance Seefeldt (Utah State University)
"Insights into the nitrogenase mechanism" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Fraser Armstrong (Oxford University)
"Electrocatalytic properties of Ni Centers in Enzymes" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:35 am | Gary Brudvig (Yale University)
"Water Oxidation Chemistry of Photosystem II" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:20 pm | Justine Roth (Johns Hopkins University)
"Tyrosyl Radicals in Heme Proteins: From Mechanisms of Formation to Involvement in Catalysis" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | RADICAL SAM ENZYMES |
| Discussion Leader: Joseph Jarrett (University of Hawaii) |
7:30 pm - 8:05 pm | Jessica Lynn Vey (MIT)
"Structural basis for glycyl radical formation by pyruvate formate-lyase activating enzyme" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:50 pm | Peter Roach (University of Southhampton)
"Thiazole Synthase from Escherichia coli" |
8:50 pm - 9:00 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |