Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Protein Interaction and Assembly
Discussion Leader: Harmeen Deol (University of Waterloo, Canada)
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:10 pm
Louise Laursen (Uppsala University, Sweden)
"Diversity of PDZ3:CRIPT Interaction: Revealed Through Ancestral Reconstruction and Analysis of Selected PDZ3 and CRIPT Variants from Present and Ancestral Species"
4:10 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
Dalia Naser (University of Waterloo, Canada)
"High Resolution Analysis of ALS-Associated Mutant SOD1 Aggregates by Amide Exchange Reveals Evidence for Prion-Like Conformational Strains"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Binding, Allostery and Action in Cells
Discussion Leaders: Wei-Ven Tee (Bioinformatics Institute, A*STAR, Singapore) and Caitlin Davis (University of Illinois at Urbana-Champaign, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Ruitao Jin (La Trobe University, Australia)
"Allosteric and Evolutional Switch for Progesterone/Spironolactone from Mineralocorticoid Receptor Agonist to Antagonist"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Shuaihua Gao (University of California, Berkeley, USA)
"Mapping Activity-Related Protein Motions in Murine Adenosine Deaminase Using Time-, Temperature- and Mutation-Dependent Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS)"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Neeladri Sen (Indian Institute of Science Education and Research, Pune (IISER Pune), India)
"Characterizing Protein Surfaces for Binding Associations"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:00 pm
Introduction by Discussion Leader
9:00 pm - 9:25 pm
Meredith Rickard (University of Illinois at Urbana-Champaign, USA)
"In Cell Protein-Protein Contacts: Transient Interactions in the Crowd"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Evolution, Folding and Phase / Mentorship Component: Career Panel
Discussion Leader: Mireia Sola (Max Planck Institute for Biophysical Chemistry, Germany)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Martin Culka (Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Czech Republic)
"Toward Ab Initio Protein Folding"
9:25 am - 9:30 am
Discussion
9:30 am - 9:45 am
Samvel Avagyan (Rensselaer Polytechnic Institute, USA)
"Molecular Mechanisms of Adaptation to High Hydrostatic Pressure"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
Pratik Vyas (Weizmann Institute of Science, Israel)
"Towards a Small, Simple and Functional P-Loop Helicase"
10:10 am - 10:15 am
Discussion
10:15 am - 10:30 am
Amir Bitran (Harvard University, USA)
"Rare Codons Coordinate Co-Translational Protein Folding to Avoid Misfolded Intermediates"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Panel Discussion
Career Landscapes and Pathways in Protein Research
Elizabeth Meiering (University of Waterloo, Canada)
Daša Lipovšek (Bristol-Myers Squibb, USA)
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Engineering and Design
Discussion Leader: Ruibin Liang (Stanford University, USA)
1:30 pm - 1:35 pm
Introduction by Discussion Leader
1:35 pm - 1:50 pm
Willow Coyote-Maestas (University of Minnesota, USA)
"Differential Permissibility Is a Measure of Engineerable Allostery in an Ion Channel"
1:50 pm - 1:55 pm
Discussion
1:55 pm - 2:10 pm
Matthew Cummins (University of North Carolina at Chapel Hill, USA)
"De Novo Design of Proteins to Potently and Specifically Inhibit the G Protein, Gaq"
2:10 pm - 2:15 pm
Discussion
2:15 pm - 2:25 pm
Matthew Sternke (Johns Hopkins University, USA)
"Biophysical Investigations of Protein Consensus Sequence Stability Enhancement"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes