SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Harnessing Biology to Optimize Radiation Therapy |
7:40 pm - 8:25 pm | Keynote Lecturer: J. Martin Brown (Stanford University) "DNA repair in cancer therapy: Exploitable or not" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:20 pm | Keynote Lecturer: Michael B. Kastan (St. Jude Children’s Research Hospital) "DNA Damage Response Mechanisms: Implications for human Disease" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Increasing the effects of DNA Damage in Tumors by Chromatin Modification |
9:00 am - 9:25 am | Discussion Leader: Andre Nussensweig (National Institutes of Health) "DNA damage response and chromosome integrity" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Junjie Chen (Yale University School of Medicine) "Coordinating protein phosphorylation and ubiquitination in DNA damage response" |
10:05 am - 10:20 am | Discussion |
10:20 am - 10:45 am | Gary Kao (University of Pennsylvania School of Medicine) "Integrating DNA damage-modifying agents with standard cancer therapy: Faster, Safer, Better?" |
10:45 am - 11:00 am | Discussion |
11:00 am - 11:30 am | Coffee Break / Group Photo (11:15 am) |
11:30 am - 11:55 am | Xuetong Shen (MD Anderson Cancer Center) "Chromatin responses to DNA damage" |
11:55 am - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Tej Pandita (Washington University) "Histone Code and DNA Damage Response" |
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Modification of DNA Damage Checkpoints in Tumors and Normal Cells |
7:30 pm - 7:55 pm | Discussion Leader: Helen Piwnica-Worms (Washington Univ. School of Medicine) "Checkpoint Control in Normal and Cancer Cell Cycles" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | David Cortez (Vanderbilt University Medical Center) "Regulation of Checkpoint Activation" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Martin Lavin (Queensland Institute of Medical Research) "ATM-dependent phosphorylation of members of the MRE11 complex signals DNA double strand breaks to the cell cycle checkpoints" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Fred Bunz (Johns Hopkins University) "Uncoupling the DNA Damage Response Function from the Essential Function of Chk1" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Adaptation from Checkpoints |
9:00 am - 9:25 am | Discussion Leader: William Kaufmann (University of North Carolina) "Current status of checkpoint adaptation in normal and cancer cells" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Marco Foiani (University of Milan) "Cellular pathways influencing checkpoint activation and inactivation in response to DSB formation" |
10:05 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Jiri Bartek (Danish Cancer Society) "DNA damage checkpoints: Live cell imaging and involvement in human tumorigenesis" |
11:05 am - 11:20 am | Discussion |
11:20 am - 11:45 am | David Toczyscki (University of California, San Francisco) "Turning the checkpoint on and off" |
11:45 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Robert Hromas (University of New Mexico) "The NHEJ Repair Protein Metnase Improves Chromosomal Decatenation and Replication Fork Progression" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | Open Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Stalled Replication, Fork Cleavage, Replication Restart |
7:30 pm - 7:55 pm | Discussion Leader: Alan Lehmann (University of Sussex) "The role of ubiquitination in the replication of damaged DNA" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Wolf-Dietrich Heyer (University of California) "Recombination and DNA damage checkpoints: Joint efforts in replication fork support" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Bing Hui Shen (City of Hope National Medical Center) "FEN-1: a possible target for radiation sensitization" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Guangbin Luo (Case Western Reserve University) "Recql5 helicase is required for maintaining active replication forks in response to replication stress" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm - 11:30 pm | Poster Session |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Homologous Recombination Defects in Tumor Cells |
9:00 am - 9:25 am | Discussion Leader: Alan Ashworth (The Institute of Cancer Research) "Synthetic Lethal approaches to the treatment of cancers with DNA Repair Defects" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Alan D’Andrea (Dana-Farber Cancer Institute) "Targeting the Fanconi Anemia Pathway in Cancer Therapeutics" |
10:05 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Thomas Helleday (Radiobiology Research Institute / Churchill Hospital) "DNA replication repair: Basic mechanisms to novel anti-cancer treatments" |
11:05 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Lei Li (MD Anderson Cancer Center) "Repair of DNA interstrand crosslinks" |
11:45 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Phillip Connell (University of Chicago) "Identification of a chemical compound that stimulates the DNA binding and recombination activities of human RAD51 protein" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | Open Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Competition Between DNA DSB Repair Pathways |
7:30 pm - 7:55 pm | Discussion Leader: Rodney Rothstein (Columbia University Genetics & Development) "Pursuing new pathways in the DNA damage response" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Jac Nickoloff (The University of New Mexico) "Co-Regulation of Double-Strand Break Repair by DNA-PKcs and ATM" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Maria Jasin (Memorial Sloan-Kettering Cancer Center) "Repairing double strand breaks in mammalian cells" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Jeremy Stark (Beckman Research Institute of the City of Hope) "G2/M arrest in mammalian cells promotes chromosome break repair pathways that involve end processing" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm - 11:30 pm | Poster Session |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Effects of Hypoxia on DNA Repair |
| Discussion Leader: Amato Giaccia (Stanford University) |
9:00 am - 9:25 am | Ester Hammond "Hypoxia-induced signalling to the DNA damage signalling pathways" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Peter Glazer (Yale University School of Medicine) "Regulation of DNA repair pathways in hypoxic cells" |
10:05 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Robert Bristow (Princess Margaret Hospital) "Hypoxia and DNA-dsb repair in tumor cells: implications for genetic instability
and novel treatments" |
11:05 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Richard Kolesnick (Memorial Sloan-Kettering Cancer Center) "Vascular dysfunction and acute hypoxia impair DSB repair in tumor stem cells" |
11:45 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Christopher Kemp (Fred Hutchinson Cancer Research Center)
“Rescue of DNA damage induced apoptosis and p21 expression in p53 null mice by elimination of DNA-PK” |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | Open Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Genomic Approaches to Studying the DNA Damage Response |
7:30 pm - 7:55 pm | Discussion Leader: Janet Hall (Institut Curie) "The association of sequence variants in DNA repair and cell cycle genes with altered cancer risk" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Al Fornace (Georgetown University) "Roles for p38 MAP kinase signaling in responses to ionizing radiation" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Patrick Concannon (University of Virginia) "Radiation exposure, genetic susceptibility, and second primary breast cancer" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Matthew Coleman (Lawerence Livermore National Laboratory) "Identification of TP53 regulated networks induced by ionizing Radiation in human lymphoblastoid cells" |
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |