- 2:00 PM - Check-in and Registration
- 6:00 to 7:00 PM - Dinner
- 7:30 to 8:00 PM - Chairs' and speakers' meeting
- 7:30 to 8:30 - Breakfast
- 9:00 - M. Navab: Welcome and Opening.
- 9:15 - J. Sipe: Introductory talk to include brief in memoriam, Earl Benditt
Session 1. 9:00 am to 12.30 pm
SAA Genes: Comparative Biology, Development and Evolution: Implications for hepatic vs. extrahepatic SAA expression.
Chair and Discussion Leader: A. S. Whitehead
- 9:30 - A. S. Whitehead: The role of the SAA mRNA 5' and 3' untranslated regions in the control of SAA expression
- 10:00 - R. Kisilevsky: SAA related sequences in Aves and Agnathae
- 10:30 - J. Sipe: Extrahepatic SAA gene expression; Implications for impaired lipid metabolism in Alzheimer's disease brain
- Coffee break 15 min.
- 11:15 - Discussion
- 12:30 to 1:30 - Lunch
- Free period
- 5:00 to 6:00 pm - Posters, beer
- 6:00 pm - Dinner
Session 2. Friday 7:30 pm to 9:30 pm
SAA Genes: Polymorphisms and Regulation.
Chair and Discussion Leader: W. Liao
- 7:30 - W. Liao: What turns SAA genes on and off: Transcription factors and signaling mediators
- 8:00 - P. Woo: Human SAA genes and their differential regulation in vitro and in vivo
- 8:30 - B. Ray: SAF, a family of C2-H2 zinc finger containing transcription factors, regulates tissue-specific SAA expression
- Coffee break, 15 minutes
- 8:45 - Discussion
Session 3. 9:00 am to 12.30 pm.
SAA function: (3a) Immunological
Chair and Discussion Leader: P. Woo
- 9:00 - R. Badolato: Modulation of inflammatory responses by serum amyloid A
- 9:30 - E. Malle: The role of SAA in cholesterol homeostasis
- 10:00 - P. Woo: Is SAA a cytokine?
SAA function: (3b) Lipid metabolism
Chair and Discussion Leader: J. Sipe
- 10:30 - R. Kisilevsky: What is SAA's physiologic role during acute inflammation?
- 11:00 - W. Pruzanski: The role of SAA-sPLA2 interaction in atherosclerosis
- 11:30 - F.C. de Beer: SAA overexpression; influence on lipoprotein metabolism.
- 12:00 - B. Shreiber: ApoSAA Modulates Smooth Muscle Cell Lipid Synthesis
- 12:30 pm - Lunch
- 2:00 to 4:30 pm - Workshop: SAA and lipid metabolism. Discussion of SAA nomenclature, a brief discussion on a consensus opinion to take to the VIIIth amyloid symposium to be held in Minnesota in August.
- 4:30 to 5:30 - Business Meeting
- Dinner 6:00 pm
Session 4. 7.30 pm to 9:30 pm
SAA, inflammatory reaction, atherogenesis
Chair and Discussion Leader, L. Hedrick
- 7:30 - B. J. Van Lenten: Acute Phase HDL promote LDL retention in the artery wall: The role of Serum Amyloid A.
- 8:00 - C. Banka: SAA, HDL oxidation, and SR-B1.
- 8:30 - F.C. de Beer: SAA interaction with SR-B1.
- 9:00 - M. Navab: Inflammatory reaction and atherogenesis.
Session 5. 9:00 am to 12:00 pm
SAA and amyloidosis. Degradation and Metabolism of SAA
Chair and Discussion Leader: M. D. Benson
- 9:00 - B. Kluve-Beckerman: Amyloid deposition in murine macrophages incubated with rSAA.
- 9:30 - M. Kindy: Animal Models, Systemic AA amyloid: From precursor to fibril
- Coffee 15 minutes
- 10:15 - Discussion
- 11:00 - Godfrey S. Getz: Summary and Conclusion
- 12:00 pm - Lunch
- 1:00 pm - Busses will leave
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