SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:15 pm | Opening Remarks: Dan Raben
Introduction of Lucio Cocco and John York |
7:30 pm - 8:00 pm | Keynote Address |
7:30 pm - 8:00 pm | Robin F. Irvine, Department of Pharmacology, University of Cambridge, Cambridge UK
"Signal Transduction Within the Nucleus-An Emerging Field" |
8:00 pm - 9:30 pm | Nuclear PI-PLC |
| Discussion Leader: Hitoshi Yagisawa, University of Hyogo, Japan |
8:00 pm - 8:05 pm | Introduction |
8:05 pm - 8:35 pm | Alberto Martelli, Universita di Bologna, Italy "Phospholipase C-ß Family Isoforms and Nuclear Signaling" |
8:35 pm - 9:05 pm | Hitoshi Yagisawa, University of Hyogo, Japan "Mechanisms of the Nucleo-cytoplasmic shuttling of PI-PLCσ1" |
MONDAY |
7:30 am - 8:20 am | Breakfast |
9:00 am - 12:30 pm | Nuclear PI Kinases and Inositol Phosphates |
| Discussion Leader: John York, Duke University |
9:00 am - 9:05 am | Introduction |
9:05 am - 9:35 am | Nal Divecha, The Netherlands Cancer Institute, The Netherlands "Stressing the Importance of Nuclear Phosphoinositides" |
9:35 am - 10:05 am | John York, Duke University, Durham NC "Inositol Polyphosphates as Regulators of Nuclear Function" |
10:05 am - 10:35 am | Jeremy Thorner, University of California, Berkeley, Berkeley CA
"Subcellular localization of phosphoinositide production: Nucleocytoplasmic trafficking of Pik1 (PtdIns 4-kinase-beta) and Plc1 (PLC-delta) in the yeast Saccharomyces cerevisiae" |
10:35 am - 11:00 am | Coffee |
11:00 am - 11:30 am | Richard A. Anderson, University of Wisconsin, Madison WI
"Nuclear Phosphoinositide Signaling" |
11:30 am - 11:50 am | Short Talk: Xuetong (Snow) Shen "Chromatin remodeling and DNA damage repair" |
11:50 am - 12:10 pm | Short Talk: Rashna Bhandari "Inositol pyrophosphate mediated protein phosphorylation" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Nuclear PI 3-kinase |
| Discussion Leader: Keqiang Ye, Emory University, Atlanta GA |
7:30 pm - 7:35 pm | Introduction |
7:35 pm - 8:05 pm | Monique Breton Douillon, Institut Claude de Préval, Toulouse, France "Nuclear 3-phosphoinositide signaling in vascular smooth muscle cells" |
8:05 pm - 8:35 pm | Keqiang Ye, Emory University, Atlanta GA "PIKE/nuclear PI 3-Kinase Signaling Mediates the Anti-Apoptotic Actions of NGF in the Nucleus" |
8:35 pm - 9:05 pm | Lily Dong, University of Texas, San Antionio, TX
"Nuclear translocation of 3'-phosphoinositide-dependent protein kinase 1 (PDK-1): Regulation and Function" |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Photo |
9:00 am - 12:30 pm | Nuclear DAG and Sphingosine Metabolism |
| Discussion Leader: Vytas Bankiatis, University of North Carolina, Chapel, NC |
9:00 am - 9:05 am | Introduction |
9:05 am - 9:35 am | Mathew Topham, University of Utah, Salt Lake City, UT "Regulating Signaling Events through Diacylglycerol Kinases" |
9:35 am - 10:05 am | Alan Hunt, University of Southampton, Southampton UK "Dynamic Lipidomics of the Nucleus" |
10:05 am - 11:00 am | Coffee |
11:00 am - 11:30 am | Shun-ichi Nakamura, Kobe University Graduate School of Medicine, Kobe, Japan "Sphingosine Kinase 2 Is A Nuclear Protein and Inhibits DNA Synthesis" |
11:30 am - 11:50 am | Short Talk: Nigel Pyne "Nuclear localization of LPA receptor" |
11:50 am - 12:10 pm | Short Talk: Andrew Morris "Inner nuclear membrane localization of two integral membrane lipid phosphatase family proteins mediated by an N-terminal sorting sequence" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Arachidonic Acid and Its Metabolism at the Nucleus |
| Discussion Leader: Edward Dennis, University of California, San Diego, CA |
7:30 pm - 7:35 pm | Introduction |
7:35 pm - 8:05 pm | Edward Dennis, University of California, San Diego, CA: LIPID MAPS "Phospholipase A2 and Eicosanoidomics" |
8:05 pm - 8:35 pm | Roy J. Soberman, Massachusetts General Hospital Charlestown, MA "Nuclear Lipoxygenase Organization" |
8:35 pm - 9:05 pm | Thomas Brock, University of Michigan, Ann Arbor MI "Regulation of 5-Lipoxygenase Enzyme Activity Within the Nucleus by Calcium and Arachidonic Acid" |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Nuclear Glycosylations |
| Discussion Leader: Gerald W. Hart, The Johns Hopkins University, Baltimore MD |
9:00 am - 9:05 am | Introduction |
9:05 am - 9:35 am | Gerald W. Hart, The Johns Hopkins University, Baltimore MD "Dynamic O-GlcNAc Modification of Nuclear Proteins: Reciprocity with Phosphorylation and Roles in Signaling & Transcription" |
9:35 am - 10:05 am | Jeff Kudlow, University of Alabama at Birmingham, Birmingham, AL "O-linked Protein Glycosylation (O-GlcNAc) in the control of Transcription" |
10:05 am - 10:35 am | Robert W. Ledeen, University of Medicine and Dentistry of New Jersey, Newark, NJ "Nuclear Gangliosides: Their Role in Nuclear Calcium Regulation" |
10:35 am - 11:00 am | Coffee |
11:00 am - 11:20 am | Short Talk: Viswanathan Natarajan "Nuclear sphingosine-1-phosphate receptors" |
11:20 am - 11:40 am | Short Talk: Colin Stewart "laminopathies and nuclear signaling" |
11:40 am - 12:00 pm | Short Talk: Sandra Marmiroli "lamin A/C is a nuclear substrate for AKT" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Nuclear Signaling Function I: Chromatin Remodeling |
| Discussion Leader: Gerald Crabtree, Stanford University, Stanford, CA |
7:30 pm - 7:35 pm | Introduction |
7:35 pm - 8:05 pm | Karlene Cimprich, Stanford University, Stanford, CA "Sensing and Responding to DNA Damage by the Nuclear Kinase ATR" |
8:05 pm - 8:35 pm | Gerald Crabtree, Stanford University, Stanford, CA "Nuclear Signals and ATP-dependent Chromatin Remodeling" |
8:35 pm - 9:05 pm | Or Gozani, Harvard Medical School, Boston, MA Signaling at Chromatin "PHD Fingers as Nuclear Phosphoinositide Receptors" |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Nuclear Signaling Function II: Transcription, Splicing and Export |
| Discussion Leader: Joe Baldassare, St. Louis University, St. Louis MO |
9:00 am - 9:05 am | Introduction |
9:05 am - 9:35 am | Gary S. Stein, University of Massachusetts Medical School, Worcester, MA "Intranuclear organization and assembly of transcriptional regulatory machinery: Implications for biological control and cancer" |
9:35 am - 10:05 am | Susan R. Wente, Vanderbilt University, Nashville TN "Regulation of mRNA export by the Inositol Hexakisphosphate Pathway" |
10:05 am - 10:35 am | Maureen Powers, Emory University, Atlanta, GA "Nup153 and Nup98 Mediate Transcription-dependent Mobility" |
10:35 am - 11:00 am | Coffee |
11:05 am - 11:35 am | Primal de Lanerolle, University of Illinois, Chicago IL
"Adding Muscle to the Nucleus: Roles for Actin and Myosin I in Transcription" |
11:35 am - 11:55 am | Short Talk: Greg Miller "Structure determination of inositol kinases" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Nuclear Signaling Function III: Nuclear Signaling and Disease |
| Discussion Leader: Howard Worman, Columbia University |
7:30 pm - 7:35 pm | Introduction |
7:35 pm - 8:05 pm | Howard Worman, Columbia University, New York, NY "Role of the Inner Nuclear Membrane in Signal Transduction" |
8:05 pm - 8:35 pm | Alan Diehl, University of Pennsylvania, Philadelphia, PA "Nuclear GSK3/CyclinD1/CDK4 in Cancers" |
8:35 pm - | Closing Keynote Address: Robin F. Irvine, Department of Pharmacology, University of Cambridge, Cambridge UK |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |