Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Keynote Session: Ab Initio Reconstruction of Cellular Landscapes with cryoDRGN
Discussion Leader: Ryan Feathers (Princeton University, United States)
3:15 pm - 3:45 pm
Ellen Zhong (Princeton University, United States)
"Ab Initio Reconstruction of Cellular Landscapes with cryoDRGN"
3:45 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Transformative Tools: Progress in Software and Hardware
Discussion Leader: Fabian Eisenstein (ETH Zurich, Switzerland)
5:30 pm - 5:50 pm
Introduction by Discussion Leader
5:50 pm - 6:05 pm
Marc Aurèle Gilles (Princeton University, United States)
"A Bayesian Framework for Cryo-EM Heterogeneity Analysis Using Regularized Covariance Estimation"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
Jesse Hansen (Institute of Science and Technology Austria, Austria)
"cryoSPARTAN: Single Particle Reconstruction of in Situ Actin Networks"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
Gaia Perone (Human Technopole, Italy)
"SOLIST: an Optimized Cryo-Lift-Out Procedure Enables a Biopsy at the Nanoscale"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Alexandra Birtasu (Goethe University Frankfurt, Germany)
"The Molecular Architecture of the Kidney Slit Diaphragm Revealed by Cryo-Electron Tomography"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Rahel Woldeyes (Stanford University, United States)
"Cryo-Electron Tomography Reveals the Structural Diversity of Cardiac Proteins in their Cellular Context"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Exploring Biological Landscapes with Innovative Multiscale 3DEM Techniques
Discussion Leader: Michelle Fry (Massachusetts General Hospital, United States)
9:00 am - 9:15 am
Juan Carlos De la Concepcion (Gregor Mendel Institute for Molecular Plant Biology, Austria)
"Analysis of The Cellular Basis of Plant Fungal Infection by Electron Cryo-Tomography"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Souvik Naskar (Imperial College London, United Kingdom)
"Twisting Tale of Bacterial ESCRT-III-like Protein: Architectural Insights into Membrane Remodeling and Repair Under Stress"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Chuchu Wang (Stanford University, United States)
"Discovery of a New Binding Partner of the Synaptic Vesicle V-ATPase by Cryo-ET/Cryo-EM"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Jeremy Hollis (Fred Hutchinson Cancer Center, United States)
"Dynamic Structural Mimicry by a Novel Cell Surface Receptor Domain"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Guendalina Marini (CSSB, Germany)
"Structural Journey of an Insecticidal Protein Against Western Corn Rootworm"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Akanksha Thawani (UC Berkeley, United States)
"Genetic Architects: How the LINE-1 Retrotransposon Crafts the Human Genome"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Navigating Career Transitions
Discussion Leader: Ximena Zottig (University of Massachusetts Chan Medical School, United States)
1:30 pm - 2:30 pm
Panel Discussion
Navigating Career Transitions
Alex de Marco (New York Structural Biology Center, United States)
Abhay Kotecha (Thermo Fisher Scientific, The Netherlands)
Ariane Briegel (Leiden University, The Netherlands)
Philipp Erdmann (Human Technopole, Italy)
Sjors Scheres (MRC Laboratory of Molecular Biology, United Kingdom)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes