Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Structure and Function of Wnt Signaling
Discussion Leader: Madelon Maurice (University Medical Center Utrecht, The Netherlands)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Sebastian Guettler (The Institute of Cancer Research (ICR), London, UK, United Kingdom)
"Molecular Mechanisms of the Beta-Catenin Destruction Complex and Its Regulation by Tankyrase"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Yvonne Jones (University of Oxford, United Kingdom)
"Structural Insights into the Extracellular Modulation of Wnt Signalling"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
Rami Hannoush (EpiBiologics, United States)
"Dissecting the Wnt Pathway in Cancer and Tissue Regeneration: A Molecular and Pharmacological Perspective"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanisms of Wnt Signal Transduction
Discussion Leader: Xi He (Boston Children's Hospital / Harvard Medical School, United States)
9:00 am - 9:25 am
Feng Cong (Novartis Institutes for BioMedical Research, United States)
"Regulation of Beta-Catenin Signaling at the Cell Surface"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Wenqing Xu (ShanghaiTech University, China)
"Structural Insights into Wnt Signalosome Assembly"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Claudia Janda (Princess Maxima Center for Pediatric Oncology, The Netherlands)
"Structure of the Wnt-Frizzled-LRP6 Initiation Complex Reveals the Basis for Coreceptor Discrimination"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
Melissa Gammons (MRC Laboratory of Molecular Biology, United Kingdom)
"GSK3 and AP-2 Clathrin Adaptor Synergize to Nucleate Wnt Signalosome Assembly at the LRP6 Co-Receptor"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Akira Kikuchi (Osaka University, Japan)
"Oncogenic Transcription Difference Between Wnt Signal-Activated Hepatocellular Carcinoma and Colorectal Carcinoma"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Anton Venhuizen (UMC Utrecht, The Netherlands)
"Multivalent Interactions Between the DIX domain and Intrinsically Disordered Regions of AXIN1 Provide a Tunable System for ß-catenin Destruction Complex Assembly, Dynamics and Activity"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Gary Davidson (Karlsruhe Institute of Technology (KIT), Germany)
"N-Glycosylation of LRP6 by B3GnT2 Promotes Wnt/ß-catenin Signaling"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:25 pm
Renee Van Amerongen (University of Amsterdam, The Netherlands)
"Tissue-Specific Initiation and Interpretation of WNT/CTNNB1 Signaling"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Madelon Maurice (University Medical Center Utrecht, The Netherlands) and Michael Ranes (University of Oxford , United Kingdom)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Wnt Signaling in Diseases
Discussion Leader: Yi Arial Zeng (Chinese Academy of Sciences, China)
6:00 pm - 6:25 pm
Bruno Reversade (KAUST (Saudi Arabia) & NUS (Singapore), Saudi Arabia)
"WNTLESSness in Zaki Syndrome is Druggable with a Small Molecule WNT Agonist"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:55 pm
Kaitlin Basham (Huntsman Cancer Institute, United States)
"Wnt Inhibitor ZNRF3 in Aging and Cancer"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Claudio Cantù (Linköping University, Sweden)
"TBX3 Orchestrates a WNT/Beta-Catenin-Dependent Transcriptional Program in Metastatic Colorectal Cancer"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Sara Bologna (CEITEC MU, Czech Republic)
"CK1-DVL Complex Formation: To Be or Not to Be (Auto)phosphorylated?"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:55 pm
Owen Sansom (CRUK Beatson Institute, United Kingdom)
"Finding Novel Targets Downstream of Ligand Independent Wnt Pathway Mutations in Intestine and Liver Cancer"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Wnt Signaling in Tissue Homeostasis and Organoids
Discussion Leader: Elizabeth Vincan (University of Melbourne and the Victorian Infectious Diseases Reference Laboratory (VIDRL), Australia)
9:00 am - 9:25 am
Vivian Li (The Francis Crick Institute, United Kingdom)
"WNT Signal Targeting and Intestinal Bioengineering"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Vanessa Puñal (University of Michigan, United States)
"Building Brains for Sensory Perception"
9:40 am - 9:45 am
Discussion
9:45 am - 10:10 am
Andy Yang (University of Toronto, Canada)
"Unravelling the Molecular Mechanisms of Neural Patterning and Generation of Dopamine Neurons using Antibodies Targeting Wnt Receptors"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Shinji Takada (National Institute for Basic Biology, Japan)
"Intercellular Exchange of Wnt Ligands Reduces Heterogeneity in the Neuromesodermal Progenitor Cell Population and Enhances its Robustness"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Selma Masri (University of California, Irvine, United States)
"Leveraging Organoids to Dissect the Role of the Circadian Clock in Cancer"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Sergio Acebron (Heidelberg University, Germany)
"A Signalling Rheostat Controls Chromosome Segregation Fidelity During Neurogenesis"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Dominic Bernkopf (University Erlangen, Germany)
"Microtubule Anchoring of Axin Counteracts Wnt Pathway Activation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:25 pm
Hans Clevers (F. Hoffmann-La Roche Ltd, Switzerland)
"Organoids Model Human Disease"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Wnt Signaling in Development
Discussion Leader: Christof Niehrs (Institute of Molecular Biology (IMB), Germany)
6:00 pm - 6:25 pm
Terry Yamaguchi (NCI, NIH, United States)
"Wnt Signaling Pathways and the Regulation of Axial Progenitors"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Ghalia Saad Siddiqui (Dartmouth, United States)
"The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:10 pm
Bart Williams (Van Andel Research Institute, United States)
"Modeling Robinow Syndrome in the Mouse"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Pascal Therond (CNRS, France)
"Role of Arf6 in Wingless Signalling Pathway During Drosophila wing Development"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:55 pm
Ken Cadigan (University of Michigan, United States)
"SOX Transcription Factors Regulate Genomic Specificity of WNT-Responsive Gene Expression"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
ßcatenin-Independent Signaling
Discussion Leader: David Strutt (University of Sheffield, United Kingdom)
9:00 am - 9:25 am
Yingzi Yang (Harvard School of Dental Medicine, United States)
"Wnt/Planar Cell Polarity Signaling in Vertebrate Development and Disease"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Bo Gao (The Chinese University of Hong Kong, Hong Kong SAR China)
"Post-Translational Regulation of Wnt/PCP Signaling"
9:40 am - 9:45 am
Discussion
9:45 am - 10:10 am
Vitezslav Bryja (Masaryk University, Czech Republic)
"C-Terminal Elongation of DVL3 by Polyglutamylation Controls its Liquid-Liquid Phase Separation and Function in the Non-Canonical Wnt Pathway"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Danelle Devenport (Princeton University, United States)
"Multiscale Coordination of Planar Cell Polarity"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Helen Strutt (University of Sheffield, United Kingdom)
"Reconstructing Asymmetric Intercellular Complex Formation in Planar Polarity"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
Ashani Weeraratna (Johns Hopkins, United States)
"Age Against the Machine: How Aging Promotes Tumor Progression"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:25 pm
David Virshup (Duke-NUS Medical School, Singapore)
"Wnt Regulation of MAPK Signaling – The Lipid Connection"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Wnt Secretion, Regulation of Gene Expression and Nuclear Mechanisms
Discussion Leader: Ken Cadigan (University of Michigan, United States)
6:00 pm - 6:25 pm
Michael Boutros (German Cancer Research Center and Heidelberg University, Germany)
"Secretion of Wnt Proteins During Development and in Cancer"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:55 pm
Jean-Paul Vincent (Francis Crick Institute, United Kingdom)
"Logistics of Wnt Production and Transport"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Indrayani Waghmare (Vanderbilt University, United States)
"Understanding Glypican-based Mechanisms of Extracellular Wnt Distribution"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:50 pm
Marian Waterman (University of California, Irvine, United States)
"Wnt Signaling in Stem Cells and Cancer"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Therapeutic Targeting of Wnt Signaling
Discussion Leader: Rami Hannoush (EpiBiologics, United States)
9:00 am - 9:25 am
Lukas Dow (Weill Cornell Medicine, United States)
"Targeting WNT in Cancer: Why, When, Where, and How"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Mike Kagey (Leap Therapeutics, United States)
"Targeting the Wnt Signaling Modulator DKK1 for Oncology"
9:40 am - 9:45 am
Discussion
9:45 am - 10:10 am
Harald Junge (University of Minnesota, United States)
"Efficacy of a Frizzled4/LRP5 Agonist in Retinal Vascular Disease Models"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Somasekar Seshagiri (Antlera Therapeutics, United States)
"Wnt-mimetic ANTibodies for Regenerative Therapy"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Xiaochun Li (University of Texas Southwestern Medical Center, United States)
"Molecular Insights into Wnt Biogenesis"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Catherine Overed-Sayer (AstraZeneca, United Kingdom)
"Porcupine (PORCN) Inhibition to Treat Lung Fibrosis"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Hadir Marei (Genentech, Roche, United States)
"PROTABs: A Tool for Leveraging E3 Ubiquitin Ligases as Cell Surface Protein Degraders"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:25 pm
Karl Willert (University of California, San Diego, United States)
"Targeting FZD7 in Development and Cancer"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Wnt Signaling in Stem Cells and Tissue Regeneration
Discussion Leader: Renee Van Amerongen (University of Amsterdam, The Netherlands)
6:00 pm - 6:25 pm
Maria Cosma (Center for Genomic Regulation , Spain)
"Wnt-Dependent Master Regulators Controlling Pluripotency and Early Mouse Development"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Stefan Hoppler (University of Aberdeen, United Kingdom)
"Single-cell RNA-seq Analysis of Wnt Regulation of Human Heart Muscle Differentiation"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Michal Shoshkes Carmel (The Hebrew University of Jerusalem, Israel)
"Telocytes are a Critical Source of Wnts Essential for Hair Follicle Regeneration"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:25 pm
Christian Petersen (Northwestern University, United States)
"Wnt Signaling in Whole-Body Regeneration"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:55 pm
Yi Arial Zeng (Chinese Academy of Sciences, China)
"Harnessing Adult Stem Cells for Pancreatic Islet Regeneration"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
