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Alcohol-Induced End Organ Diseases

Gordon Research Conference

Inflammation and Cell Death: Mechanisms of Tissue Injury by Alcohol

March 24 - 29, 2019

Chairs Laura E. Nagy and Wen-Xing Ding

Vice Chairs Gyongyi Szabo and Bernd Schnabl

Contact Chairs

Four Points Sheraton / Holiday Inn Express

1050 Schooner Drive

Ventura, CA, US

Venue and Travel Information

Conference Description

The 2019 Gordon Research Conference (GRC) on Alcohol-Induced End Organ Diseases "Inflammation and Cell Death: Mechanisms of Tissue Injury by Alcohol" will provide a unique forum to bring together a diverse range of young and established scientists who are studying alcohol-related organ damage. This newly approved Gordon Research Conference exclusively addresses alcohol-induced end organ disorders and will cover a broad range of studies at the molecular, cellular, systems and organismal level, with particular emphasis on multidisciplinary work and innovative approaches.

This GRC conference will 1) provide an international forum that promotes open discussion of cutting edge research at the forefront of alcohol-induced tissue injury, 2) foster the development of the next generation of investigators to study alcohol-induced organ damage, 3) promote interaction between young and senior investigators, 4) facilitate the exchange of ideas that will shape the future directions of the alcohol and tissue injury community and 5) introduce breakthrough techniques that facilitate the understanding of mechanisms driving alcohol-induced tissue injury. This GRC conference will significantly advance current understanding of the underlying mechanisms of end organ injury and stimulate development of effective therapeutic strategies for the diagnosis, prevention and treatment of alcohol-related disorders. Talks will address questions centered on the basic mechanisms that contribute to alcohol-induced organ damage across the entire lifespan and will include wide ranging experimental systems from microbiome to humans.

The format will provide ample time for formal and informal discussions and emphasize the presentation of unpublished data, thus ensuring that the newest and most exciting developments in the field are discussed. Poster presentations will take place on each day of the meeting, allowing for widespread participation of conference attendees at all career stages. Speakers will also be selected from submitted abstracts for "late-breaking topic" talks by young investigators. Participation by young investigators will be strongly encouraged.

Related Meeting

This GRC will be held in conjunction with the "Alcohol-Induced End Organ Diseases (GRS)" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
4:00 pm - 8:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Keynote Session: Molecular and Cellular Mechanisms of Fibrosis Discussion Leaders: Jacquelyn Maher (University of California, San Francisco, USA) and Vijay Shah (Mayo Clinic, USA)
7:40 pm - 7:50 pm	Opening Remarks
7:50 pm - 8:25 pm	Rebecca Wells (University of Pennsylvania, USA) "The Complex Role of the ECM in Liver Fibrosis"
8:25 pm - 8:40 pm	Discussion
8:40 pm - 9:15 pm	Karyn Esser (University of Florida, USA) "Circadian Rhythms and the Muscle Molecular Clock: Why Muscles Need to Keep Time"
9:15 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Protein and Organelle Homeostasis: Novel Mechanisms of Alcohol-Induced Organ Injury Discussion Leader: Andras Orosz (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
9:00 am - 9:20 am	Mark Czaja (Emory University, USA) "Regulation of Inflammatory Liver Injury by Autophagy"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	Herbert Gaisano (University of Toronto, Canada) "Role of SNARE Proteins in Dysregulated Autophagy in Alcoholic Pancreatitis"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	Mark McNiven (Mayo Clinic, USA) "Ethanol-Based Perturbation of Lipid Droplet Catabolism in Hepatocytes"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	Hidekazu Tsukamoto (University of Southern California, USA) "Pyroptosis in Alcoholic Liver Disease"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	John Lemasters (Medical University of South Carolina, USA) "Mitochondrial Depolarization and Disregulated Mitophagy Occur in both Alcoholic and Non-Alcoholic Fatty Liver Disease"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	Shaogui Wang (University of Kansas Medical Center, USA) " Critical Role of TFEB-Mediated Lysosomal Biogenesis in Alcohol-Induced Pancreatitis in Mice and Humans"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Jason Correnti (Perelman School of Medicine, University of Pennsylvania, USA) "Hepatic Ceramide Reduction Alleviates Alcoholic Steatosis and Insulin Resistance in Female Mice"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Mrigya Babuta (University of Massachusetts Medical School, USA) "Impaired Autophagy Flux in Alcoholic Liver Disease: A Link Between miR155, Impaired Autophagosome Function and Exosome Production"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring. Organizers: Patricia Molina (LSU Health Sciences Center New Orleans, USA) and Samantha Yeligar (Emory University / Atlanta VA Medical Center, USA)
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Gut Derived Effectors Discussion Leaders: Ali Keshavarzian (Rush University Medical Center, USA) and Bernd Schnabl (University of California, San Diego, USA)
7:30 pm - 7:50 pm	J. Mark Brown (Lerner Research Institute, Cleveland Clinic, USA) "Small Molecule Inhibition of Gut Microbial Choline Metabolism as a Therapeutic Strategy in Alcoholic Liver Disease"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	Gabriel Perlemuter (Hôpital Antoine-Béclère (AP-HP), France) "Microbiota and Gut Barrier in Alcoholic Liver Disease"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	Derrick Samuelson (LSU Health Sciences Center New Orleans, USA) "Alcohol Consumption Alters sIgA-Binding of Intestinal Microbes"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	Venkatakrishna Jala (University of Louisville, USA) "Gut Microbial Metabolite, Urolithin A Mitigates ALD by Enhancing Gut Barrier Integrity and Blocking Inflammation"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	Avtar Meena (University of Tennessee Health Science Center, USA) "Deletion of TRPV6 Channel Attenuates Alcohol and Stress-Induced Gut Barrier Dysfunction, Endotoxemia and Liver Damage"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	Cristina Llorente (University of California, San Diego, USA) "Intestinal Stem Cell Proliferation and Differentiation in Alcoholic Liver Disease"
9:25 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Alcohol and Cell-Cell Communications: From Extracellular Vesicles to Cyto-, Chemo- and Adipokines Discussion Leaders: David Brigstock (Nationwide Children's Hospital, USA) and Samar Ibrahim (Mayo Clinic, USA)
9:00 am - 9:20 am	Gianfranco Alpini (Indiana University, USA) "Secretin Modulation of Biliary Senescence in Alcohol-Induced Liver Damage"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	Won-Il Jeong (KAIST, South Korea) "Extracellular Vesicle-Mediated Activation of Kupffer Cells in ALD"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	Natalia Nieto (University of Illinois at Chicago, USA) "HMGB-1: DAMP Extroardinare"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	Steve Kliewer (University of Texas Southwestern Medical Center, USA) "Regulation of Alcohol and Sweet Preference by the Hormone FGF21"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	Zhuan Li (The University of Kansas Medical Center, USA) "Kupffer Cells Undergo Anti-Inflammatory Changes in Response to Short-Term Alcohol Exposure"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	Kyle Poulsen (Cleveland Clinic, USA) "Hepatocyte- and Myeloid-Derived Macrophage Migration Inhibitory Factor Contribute to Steatosis and ER Stress in Models of Ethanol Feeding in Mice"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Je-Hyun Yoon (Medical University of South Carolina, USA) "Intestinal miRNA Release by Phosphorylation of RNA-Binding Protein AUF1"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Yilin Yang (Yale University, USA) "A New Mechanism of Liver Sinusoidal Endothelial Cell (LSEC) Dysfunction in Alcoholic Liver Disease: The Role of Cytochrome P450 E1 (CYP2E1) and HSP90 Acetylation"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Big Data and Bioinformatics: Emerging Insights from Omics Discussion Leader: Suthat Liangpunsakul (Indiana University School of Medicine, USA)
7:30 pm - 7:50 pm	Trina Norden-Krichmar (University of California, Irvine, USA) "Integrated 'Omics' Approach for Biomarker Discovery in Alcoholic Hepatitis"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	Mark Thursz (Imperial College London, United Kingdom) "GWAS Studies in ASH"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	Heng Zhu (Johns Hopkins University, USA) "Application of Protein Arrays in Studying Severe Alcoholic Hepatitis and Beyond"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	Adam Kim (Cleveland Clinic, USA) "miRNA Regulation of PBMCs in Alcoholic Hepatitis"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	Devanshi Seth (Centenary Institute, Royal Prince Alfred Hospital, Australia) "Clinical Risk Factors for Alcoholic Cirrhosis in a Large Cohort of Heavy Drinkers"
9:25 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Genetic Factors, Post-Metabolic Signaling and Stress Pathways Discussion Leader: Shelly Lu (Cedars-Sinai Medical Center, USA)
9:00 am - 9:20 am	Bin Gao (National Institutes of Health, USA) "Acetaldehyde Dehydrogenase 2 Deficiency, Alcoholic LIver Disease and Cancer"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	Karen Reue (University of California, Los Angeles, USA) "Lipins in Regulating Lipid Metabolism"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	Elizabeth Speliotes (University of Michigan, USA) "Human Genetic Studies Reveal Heterogenous Causes of Fatty Liver Disease"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	Pal Pacher (National Institute on Alcohol Abuse and Alcoholism, NIH, USA) "Endocannabinoid-CB1-R Signaling Contributes to the Acute Cardiovascular Effects of Alcohol: Role of Gut-Liver-Heart Connection"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	Hyeonggeug Kim (Indiana University School of Medicine, USA) "The Epigenetic Regulator SIRT6 Protects the Liver from the Alcohol-Induced Tissue Injury via Control of Oxidative Stress"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	Jennifer Valcin (University of Alabama at Birmingham, USA) "Impact of Chronic Alcohol and Hepatocyte Circadian Clock Disruption on Diurnal Rhythms of Lipid Droplet-Associated Genes and Hepatic Steatosis in Mice"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Xiaohui Wang (Harvard School of Dental Medicine, USA) "The Hippo Kinase Mst1 Protects Alcoholic Induced Liver Damage by Inhibiting Inflammation"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Jeongeun Hyun (Duke University, USA) "Dysregulated Adult Splicing Program in Hepatocytes Leads to Severe Alcoholic Hepatitis"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm	Mitochondrial Dynamics, Dysfunction and Adaptation Discussion Leaders: John Lemasters (Medical University of South Carolina, USA) and Shannon Bailey (University of Alabama at Birmingham, USA)
7:30 pm - 7:50 pm	Meng Wang (Baylor College of Medicine, USA) "Crosstalk of Microbiota and Host Mitochondria in Metabolic and Longevity Regulation"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	Srinivasan Dasarathy (Cleveland Clinic, USA) "Mitochondrial Dysfunction in Skeletal Muscle"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	Hiromi Sesaki (Johns Hopkins University School of Medicine, USA) "Mitochondrial Dynamics and Turnover in Liver Disease"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	Xiaowen Ma (University of Kansas Medical Center, USA) "Disruption of Mitochondrial Dynamics Accelerate Alcohol-Induced Liver Injury in Mouse by Regulating Mitophagy"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	Samantha Yeligar (Emory University / Atlanta VA Medical Center, USA) "Alcohol-Induced Mitochondrial Derangements in the Alveolar Macrophage"
9:25 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Translational and Clinical Approaches for Treatment of Alcohol-Induced Tissue Injury Discussion Leaders: Michele Pritchard (University of Kansas Medical Center, USA) and Elizabeth Kovacs (University of Colorado Denver, USA)
9:00 am - 9:20 am	Ramon Bataller (University of Pittsburgh, USA) "Controversies in Clinical Trials in ALD"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	Mariann Piano (Vanderbilt University School of Nursing, USA) "Cardiovascular Risk Associated with Binge Drinking in Young Adults"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	Fredrik Aberg (University of Helsinki, Finland) "Interactions Between Alcohol Consumption and Metabolic Syndrome in the General Population"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	Gyongyi Szabo (University of Massachusetts Medical School, USA) "Clinical Trials for Alcoholic Hepatitis: Anakinra"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	Ellen Burnham (University of Colorado School of Medicine, USA) "Alcohol-Associated Alterations in Lung Immunity"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Richard Parker (Leeds Liver Unit, St James's University Hospital, United Kingdom) "Severity of Human Alcoholic Liver Disease Is Associated with Reduced NAD+ Content"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Qigui Yu (Indiana University School of Medicine, USA) "Immune Checkpoint Axes Are Dysregulated in Patients with Alcoholic Hepatitis"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Systemic Effects of Alcohol: Cross-Talk Between Multiple Organs Discussion Leader: Pranoti Mandrekar (University of Massachusetts Medical School, USA)
7:30 pm - 7:50 pm	Patricia Molina (LSU Health Sciences Center New Orleans, USA) "Alcohol, Aging and HIV: Dissecting Mechanisms Driving Enhanced Comorbidities"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	Gavin Arteel (University of Pittsburgh, USA) "Lung-Liver Interactions in Alcoholic Liver Disease"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	Seonghwan Hwang (National Institute on Alcohol Abuse and Alcoholism, NIH, USA) "Adipocyte Apoptosis Enhances Hepatic Fat Accumulation and Liver Injury in the Experimental Models of Alcoholic and Nonalcoholic Steatohepatitis"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	Yongke Lu (East Tennessee State University, USA) "Adipose FGFR1 Regulates Binge Alcohol-Induced Adipolipolysis and Hepatic Fat Accumulation in Mice"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	Xun Ai (Rush University Medical Center, USA) "Stress Signaling: New Mechanisms of Alcohol-Evoked Cardiac Arrhythmias"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	Caroline Morel (University of Massachusetts Medical School, USA) "Chronic Alcohol-Induced Neuroinflammation Involves CCR2/5-Dependent Peripheral Macrophage Infiltration and Altered Synaptic Maturation"
9:25 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Research reported in this publication was supported by the National Institute On Alcohol Abuse And Alcoholism of the National Institutes of Health under Award Number U13AA025249. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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