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Alcohol-Induced End Organ Diseases

Gordon Research Conference

Multisystemic Pathophysiological Mechanisms

March 26 - 31, 2023

Chairs

and

Vice Chairs

and

Four Points Sheraton / Holiday Inn Express

1050 Schooner Drive

Ventura, California, United States

Venue and Travel Information

Conference Description

The Alcohol-Induced End Organ Diseases GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes an array of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Related Meeting

This GRC will be held in conjunction with the "Alcohol-Induced End Organ Diseases" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Alcohol: A Systemic Toxin Discussion Leader:
7:40 pm - 7:50 pm	Introduction by Discussion Leader
7:50 pm - 8:25 pm	"Closing the Treatment Gap: NIAAA Priorities"
8:25 pm - 8:40 pm	Discussion
8:40 pm - 9:15 pm	"Evolving Mechanisms of Organ Remodeling and Prospects for Treatment"
9:15 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Alcohol and Neuro-Inflammation Discussion Leader:
9:00 am - 9:20 am	"Alcohol Primes Microglia: Alternative Roles and Phenotypes in Adolescent Models"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Prenatal Alcohol Exposure, Fetal Programming and Inflammation: Unmasking Developmental Origins of Adult Disease"
9:50 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:50 am	"Involvement of Microglia in Alcohol-induced Neurodegeneration and Enhancement of Alzheimer’s Pathology"
10:50 am - 11:00 am	Discussion
11:00 am - 11:20 am	"Defining a Role of Microglia in Ethanol- and Advanced Age-Related Neurodegeneration"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Cardiometabolic Risk Factors, Alcohol Use, and Cognitive Decline in People Living with HIV"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Alcohol Use Disorder Impacts Gut Microbiota that is Mediated by External Factors, a United States Veteran Microbiome Project Study"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Effect of Gut Microbial Ethanol Production on Alcohol Use Disorder and Alcohol-Associated Liver Disease"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Ethanol Intoxication Promotes Neuroinflammation After Burn Injury via the Gut-Brain Axis"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Alcohol, the GI Barrier and Gut-Peripheral Organ Axes Discussion Leader:
7:30 pm - 7:50 pm	"The Role of The Intestinal Virome in Alcohol-Associated Liver Disease"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Gut-Organ Axes in Alcohol-Induced End Organ Disease"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Defining the Role of Calcium Channels in Alcohol-Associated Intestinal Barrier Dysfunction"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"The Role of Host and Microbial Epoxide Hydrolases in Alcohol-Associated Liver Injury and Inflammation"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Alcohol and Severe Injury Discussion Leader:
9:00 am - 9:20 am	"Mechanism(s) Underlying Intestine Immune Barrier Disruption Following Alcohol and Burn Injury"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"TBI & Alcohol Effects on Brain and Behavior"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	"Impact of Alcohol Misuse on the Development of Neuromuscular Dysfunction in Survivors of Critical Illness"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"CTLA-4 Checkpoint Inhibition in Alcohol and Sepsis"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Cathelicidin-Related Antimicrobial Peptide Gene Expression in Lungs is Impaired When Ethanol Intoxication Precedes Cutaneous Burn Injury"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Lung is More Sensitive to Alcohol Effects than Liver for Immune Dysregulation: Immuno-Metabolic Role of Branch-Chain Amino Acids and mTOR Signaling"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"In Vivo Bruton’s Tyrosine Kinase (BTK) Inhibition Attenuates Alcohol Associated Liver Disease by Regulating Granulopoiesis Involving CD84 (SLAM5)"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Alcohol and Nutrient Stress Produce Differential Lipid Droplet Accumulation in Rat Primary Hepatocyte Spheroids"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Alcohol, Cancer Risk and Outcome Discussion Leader:
7:30 pm - 7:50 pm	"Alcohol Intake and Breast Cancer - Latest Evidence and Remaining Gaps"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Alcohol and the Hepatic Microenvironment: A Recipe for Colorectal Liver Metastasis"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	"Zone-Specific Hepatocarcinogenesis during ASH or NASH Progression to HCC"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"Mitochondrion-Nucleus PDH1 Transfer Drives Epigenetic NANOG Reprograming of Tumor-Initiating Cells in Alcohol-Associated HCC"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Hepatic Stellate Cells: Regulating More than Liver Fibrosis"
9:20 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Early Detection and Intervention for End Organ Damage Discussion Leader:
9:00 am - 9:20 am	"Management and Treatment of AUD in patients with ALD"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Non-invasive Imaging of Alcohol-associated Liver Disease"
9:50 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:50 am	"Treatments For Alcoholic Pancreatitis"
10:50 am - 11:00 am	Discussion
11:00 am - 11:15 am	"Lack of Reticulon 4B (Nogo-B) Increases Endoplasmic Reticulum Sheet Structure and Facilitates Anti-Inflammatory Macrophage Polarization, Mitigating Alcohol-Associated Liver Injury"
11:15 am - 11:20 am	Discussion
11:20 am - 11:35 am	"Regulation of Liver Cell Remodeling and Ductular Reaction by Persistent mTORC1 Activation in Alcoholic Hepatitis"
11:35 am - 11:40 am	Discussion
11:40 am - 11:50 am	"Examination of Zinc, S-adenosylmethionine, and Combination Therapy Versus Placebo in Veterans with Alcohol Use Disorders"
11:50 am - 11:55 am	Discussion
11:55 am - 12:05 pm	"Neutrophil Extracellular Traps Activate Hepatic Stellate Cell and Monocytes via NLRP3 Sensing in Alcohol-Induced Acceleration of NASH Fibrosis"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Alcohol and Comorbidities Discussion Leader:
7:30 pm - 7:50 pm	"Cardiovascular Effects of Alcohol in Aging"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Alcohol Potentiates Intestinal Pathologies Post Ulcerative Colitis"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Alcohol, Lung Disease and Lung Transplant"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Altered Innate Immune Responses in Peripheral Blood Mononuclear Cells in Heavy Drinkers with Obesity"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Alcohol, Inflamm-Aging and Senescence Across the Aging Spectrum Discussion Leader:
9:00 am - 9:20 am	"Moderate Alcohol Intake, Metabolism and Aging"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Alcohol, Aging and Epigenetic Clocks"
9:50 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:50 am	"Mast Cell Regulation of Alcohol-Induced Liver Phenotypes"
10:50 am - 11:00 am	Discussion
11:00 am - 11:20 am	"Chronic Alcohol Drinking Disrupts Monocyte Differentiation in Bone Marrow Niche"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Aging Exacerbates Alcohol-Induced Steatosis and Inflammation but Not Cell Death in Mice"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Assessing the Acute and Multiple Dosing Effects of Alcohol Exposure on Fetal Brain Vasculature with Optical Coherence Angiography"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Targeted Metabolomics of Gut-Derived Microbial Metabolites in Alcohol-Associated Liver Disease"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Transcriptional and Post-Transcriptional Landscapes of Alcohol-Associated Human Liver Diseases"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Informatic Advances in Alcohol-Induced End-Organ Diseases Discussion Leader:
7:30 pm - 7:50 pm	"Methods in Artificial Intelligence to Help Advance Identification and Treatment for Unhealthy Alcohol Use in Hospitalized Patients"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Using Causal Graphs in Biomedical Research"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Leveraging PaTH/PCORnet resources for Comparative Effectiveness Research"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Multiplex Immunostaining and RNA-Sequencing Analysis of Inflammation in Severe Alcoholic Hepatitis Patients"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Characterizing Altered Spatial Gene Expression in a Murine Model of Alcohol-Associated Acute Kidney Injury"
9:25 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

University of Colorado Denver, Department of Surgery, GITES

Kovacs Family Fund

Bin Gao, MD, PhD

WENXING DING

Huiping Zhou

Loyola University Chicago

Research reported in this publication was supported by the National Institute On Alcohol Abuse And Alcoholism of the National Institutes of Health under Award Number R13AA028908. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health

Conference Links

Conference History Alcohol-Induced End Organ Diseases (GRS)

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