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Alcohol-Induced End Organ Diseases

Gordon Research Conference

Multisystemic Pathophysiological Mechanisms

March 26 - 31, 2023

Chairs Elizabeth J. Kovacs and Gavin E. Arteel

Vice Chairs Patricia Molina and Carol A. Casey

Contact Chairs

Four Points Sheraton / Holiday Inn Express

1050 Schooner Drive

Ventura, CA, United States

Venue and Travel Information

Conference Description

The Alcohol-Induced End Organ Diseases GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Related Meeting

This GRC will be held in conjunction with the "Alcohol-Induced End Organ Diseases" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Alcohol: A Systemic Toxin Discussion Leader: Hidekazu Tsukamoto (University of Southern California, United States)
7:40 pm - 7:50 pm	Introduction by Discussion Leader
7:50 pm - 8:25 pm	George Koob (National Institute on Alcohol Abuse and Alcoholism, NIH, United States) "Closing the Treatment Gap: NIAAA Priorities"
8:25 pm - 8:40 pm	Discussion
8:40 pm - 9:15 pm	Scott Friedman MD (Icahn School of Medicine at Mount Sinai, United States) "Evolving Mechanisms of Organ Remodeling and Prospects for Treatment"
9:15 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Alcohol and Neuro-Inflammation Discussion Leader: Fulton Crews (UNC Bowles Center for Alcohol Studies, United States)
9:00 am - 9:20 am	Kimberly Nixon (The University of Texas at Austin, United States) "Alcohol Primes Microglia: Alternative Roles and Phenotypes in Adolescent Models"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	Joanne Weinberg (University of British Columbia, Vancouver, BC, Canada V6T1Z3, Canada) "Prenatal Alcohol Exposure, Fetal Programming and Inflammation: Unmasking Developmental Origins of Adult Disease"
9:50 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:50 am	Leon Coleman (UNC-CH Bowles Center for Alcohol Studies, United States) "Involvement of Microglia in Alcohol-induced Neurodegeneration and Enhancement of Alzheimer’s Pathology"
10:50 am - 11:00 am	Discussion
11:00 am - 11:20 am	Paige Anton (University of Colorado Anschutz, United States) "Defining a Role of Microglia in Ethanol- and Advanced Age-Related Neurodegeneration"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	Taylor Fitzpatrick-Schmidt (LSUHSC-New Orleans, United States) "Cardiometabolic Risk Factors, Alcohol Use, and Cognitive Decline in People Living with HIV"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	Andrew Hoisington (Department of Veteran Affairs, United States) "Alcohol Use Disorder Impacts Gut Microbiota that is Mediated by External Factors, a United States Veteran Microbiome Project Study"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Cynthia Hsu (University of California, San Diego, United States) "Effect of Gut Microbial Ethanol Production on Alcohol Use Disorder and Alcohol-Associated Liver Disease"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Rachel McMahan (University of Colorado Anschutz Medical Campus, United States) "Ethanol Intoxication Promotes Neuroinflammation After Burn Injury via the Gut-Brain Axis"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: Rebecca McCullough (University of Colorado Anschutz Medical Campus, United States) and Leon Coleman (UNC-CH Bowles Center for Alcohol Studies, United States)
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Alcohol, the GI Barrier and Gut-Peripheral Organ Axes Discussion Leader: Bin Gao (National Institutes of Health, United States)
7:30 pm - 7:50 pm	Bernd Schnabl (University of California, San Diego, United States) "The Role of The Intestinal Virome in Alcohol-Associated Liver Disease"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	Gyongyi Szabo (Beth Israel Deaconess Medical Center / Harvard Medical School, United States) "Gut-Organ Axes in Alcohol-Induced End Organ Disease"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	Radhakrishna (RK) Rao (University of Tennessee Health Science Center, United States) "Defining the Role of Calcium Channels in Alcohol-Associated Intestinal Barrier Dysfunction"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	Irina Kirpich (University of Louisville, United States) "The Role of Host and Microbial Epoxide Hydrolases in Alcohol-Associated Liver Injury and Inflammation"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Alcohol and Severe Injury Discussion Leader: H. Joe Wang (NIAAA/NIH, United States)
9:00 am - 9:20 am	Mashkoor Choudhry (Loyola University Chicago Health Sciences Division, United States) "Mechanism(s) Underlying Intestine Immune Barrier Disruption Following Alcohol and Burn Injury"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	Nicholas Gilpin (LSU Health Sciences Center New Orleans, United States) "TBI & Alcohol Effects on Brain and Behavior"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	Sarah Jolley (University of Colorado, United States) "Impact of Alcohol Misuse on the Development of Neuromuscular Dysfunction in Survivors of Critical Illness"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	Craig Coopersmith (Emory University, United States) "CTLA-4 Checkpoint Inhibition in Alcohol and Sepsis"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	Shanawaj Khair (University of Colorado School of Medicine, United States) "Cathelicidin-Related Antimicrobial Peptide Gene Expression in Lungs is Impaired When Ethanol Intoxication Precedes Cutaneous Burn Injury"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	Lenny Pommerolle (National Institutes of Health, United States) "Lung is More Sensitive to Alcohol Effects than Liver for Immune Dysregulation: Immuno-Metabolic Role of Branch-Chain Amino Acids and mTOR Signaling"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Prashanth Thevkar Nagesh (BIDMC, Harvard Medical School,, United States) "In Vivo Bruton’s Tyrosine Kinase (BTK) Inhibition Attenuates Alcohol Associated Liver Disease by Regulating Granulopoiesis Involving CD84 (SLAM5)"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Eden Gallegos (Louisiana State University Health Sciences Center New Orleans, United States) "Alcohol and Nutrient Stress Produce Differential Lipid Droplet Accumulation in Rat Primary Hepatocyte Spheroids: Implications in Alcohol-Mediated Liver Injury"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Alcohol, Cancer Risk and Outcome Discussion Leaders: Huiping Zhou (Virginia Commonwealth University, United States)
7:30 pm - 7:50 pm	Mary Beth Terry (Columbia University, United States) "Alcohol Intake and Breast Cancer - Latest Evidence and Remaining Gaps"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	Benita McVicker (University of Nebraska Medical Center , United States) "Alcohol and the Hepatic Microenvironment: A Recipe for Colorectal Liver Metastasis"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	tian Tian (Tulane University of Louisiana, United States) "Zone-Specific Hepatocarcinogenesis during ASH or NASH Progression to HCC"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	Keigo Machida (University of Southern California, United States) "Mitochondrion-Nucleus PDH1 Transfer Drives Epigenetic NANOG Reprograming of Tumor-Initiating Cells in Alcohol-Associated HCC"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	Robert Schwabe (Columbia University, United States) "Hepatic Stellate Cells: Regulating More than Liver Fibrosis"
9:20 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Early Detection and Intervention for End Organ Damage Discussion Leader: Laura Nagy (Liver Disease Research Center, Cleveland Clinic Lerner Research Institute, United States)
9:00 am - 9:20 am	Lorenzo Leggio (National Institutes of Health, United States) "Management and Treatment of AUD in patients with ALD"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	Jay Luther (Massachusetts General Hospital, United States) "Alcohol and Health Outcomes"
9:50 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:50 am	Jessica Mellinger (University of Michigan, United States) "Non-invasive Imaging of Alcohol-associated Liver Disease"
10:50 am - 11:00 am	Discussion
11:00 am - 11:20 am	Stephen Pandol (Cedars-Sinai Medical Center, United States) "Treatments For Alcoholic Pancreatitis"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	Yilin Yang (Yale University, United States) "Lack of Reticulon 4B (Nogo-B) Increases Endoplasmic Reticulum Sheet Structure and Facilitates Anti-Inflammatory Macrophage Polarization, Mitigating Alcohol-Associated Liver Injury"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	Wen-Xing Ding (University of Kansas Medical Center, United States) "Regulation of Liver Cell Remodeling and Ductular Reaction by Persistent mTORC1 Activation in Alcoholic Hepatitis"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Kathryn Crotty (Emory University, Department of Medicine, United States) "Examination of Zinc, S-adenosylmethionine, and Combination Therapy Versus Placebo in Veterans with Alcohol Use Disorders"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Mrigya Babuta (Beth Israel Deaconess Medical Center and Harvard Medical School, United States) "Neutrophil Extracellular Traps Activate Hepatic Stellate Cell and Monocytes via NLRP3 Sensing in Alcohol-Induced Acceleration of NASH Fibrosis"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Alcohol and Comorbidities Discussion Leader: Vijay Shah (Mayo Clinic, United States)
7:30 pm - 7:50 pm	Pal Pacher (National Institute on Alcohol Abuse and Alcoholism, NIH, United States) "Cardiovascular Effects of Alcohol in Aging"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	Abigail Cannon (Loyola University Chicago Health Science Division, United States) "Alcohol Potentiates Intestinal Pathologies Post Ulcerative Colitis"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	Erin Lowery (University of Wisconsin-Madison, United States) "Alcohol, Lung Disease and Lung Transplant"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	Adam Kim (UConn Health, United States) "Altered Innate Immune Responses in Peripheral Blood Mononuclear Cells in Heavy Drinkers with Obesity"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Alcohol, Inflamm-Aging and Senescence Across the Aging Spectrum Discussion Leader: Andras Orosz (National Institute on Alcohol Abuse and Alcoholism, NIH, United States)
9:00 am - 9:20 am	Brian Kennedy (National University of Singapore, Singapore) "Moderate Alcohol Intake, Metabolism and Aging"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	Falk Lohoff (National Institues of Health / NIAAA, United States) "Alcohol, Aging and Epigenetic Clocks"
9:50 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:50 am	Heather Francis (Indiana University, United States) "Mast Cell Regulation of Alcohol-Induced Liver Phenotypes"
10:50 am - 11:00 am	Discussion
11:00 am - 11:20 am	Ilhem Messaoudi (University of Kentucky, United States) "Chronic Alcohol Drinking Disrupts Monocyte Differentiation in Bone Marrow Niche"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	Sha Neisha Williams (KUMC, United States) "Aging Exacerbates Alcohol-Induced Steatosis and Inflammation but Not Cell Death in Mice"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	Jessica Gutierrez (University of Houston, United States) "Assessing the Acute and Multiple Dosing Effects of Alcohol Exposure on Fetal Brain Vasculature with Optical Coherence Angiography"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Marko Mrdjen (Cleveland Clinic, United States) "Targeted Metabolomics of Gut-Derived Microbial Metabolites in Alcohol-Associated Liver Disease"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Ullas Valiya Chembazhi (University of Illinois, Urbana-Champaign, United States) "Transcriptional and Post-Transcriptional Landscapes of Alcohol-Associated Human Liver Diseases"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Informatic Advances in Alcohol-Induced End-Organ Diseases Discussion Leader: Vasilis Vasiliou (Yale School of Public Health, United States)
7:30 pm - 7:50 pm	Majid Afshar (University of Wisconsin - Madison, United States) "Methods in Artificial Intelligence to Help Advance Identification and Treatment for Unhealthy Alcohol Use in Hospitalized Patients"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	Takis Benos (University of Florida, United States) "Using Causal Graphs in Biomedical Research"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	Kathleen McTigue (University of Pittsburgh, United States) "Leveraging PaTH/PCORnet resources for Comparative Effectiveness Research"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	Dechun Feng (NIH/NIAAA, United States) "Multiplex Immunostaining and RNA-Sequencing Analysis of Inflammation in Severe Alcoholic Hepatitis Patients"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	Peter Harris (University of Colorado Denver, United States) "Characterizing Altered Spatial Gene Expression in a Murine Model of Alcohol-Associated Acute Kidney Injury"
9:25 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

University of Colorado Denver, Department of Surgery, GITES

Kovacs Family Fund

Bin Gao, MD, PhD

WENXING DING

Huiping Zhou

Loyola University Chicago

Conference Links

Conference History Alcohol-Induced End Organ Diseases (GRS)

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