Sunday
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2:00 pm - 9:00 pm |
Arrival and Check-in
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
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7:40 pm - 9:30 pm |
Motor Neuron Gene Discovery
Discussion Leader: Bryan Traynor (National Institutes of Health, USA)
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7:40 pm - 8:20 pm |
David Goldstein (Columbia University Medical Center , USA)
"Genomics and Precision Medicine in ALS"
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8:20 pm - 8:35 pm |
Discussion
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8:35 pm - 9:15 pm |
John Landers (University of Massachusetts Medical School, USA)
"ALS Genetics: Where Are We Now and Where Are We Going?"
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9:15 pm - 9:30 pm |
Discussion
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Monday
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7:30 am - 8:30 am |
Breakfast
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8:30 am - 9:00 am |
Group Photo
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9:00 am - 12:30 pm |
In Vivo Models of Motor Neuron Diseases
Discussion Leader: Don Cleveland (Ludwig Institute for Cancer Research, USA)
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9:00 am - 9:35 am |
Cat Lutz (The Jackson Laboratory, USA)
"Mouse Models for ALS, New and Old"
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9:35 am - 9:45 am |
Discussion
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9:45 am - 10:20 am |
Laura Ranum (University of Florida College of Medicine, USA)
"C9ORF72 ALS/FTD: Molecular Insights and Therapeutic Efforts to Block Paralysis and Neurodegeneration in C9-BAC Transgenic Mice"
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10:20 am - 10:30 am |
Discussion
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10:30 am - 11:00 am |
Coffee Break
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11:00 am - 11:35 am |
Robert Baloh (Cedars-Sinai Medical Center, USA)
"Role of C9orf72 in Neurodegeneration and Neuroinflammation"
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11:35 am - 11:45 am |
Discussion
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11:45 am - 11:55 am |
Selected from Poster Abstracts: Aaron Burberry (Harvard University, USA)
"A New Mouse Model of C9ORF72-ALS Containing both Gain and Loss of Function Mutations"
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11:55 am - 12:00 pm |
Discussion
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12:00 pm - 12:10 pm |
Selected from Poster Abstracts: Valeria Gerbino (Columbia University, USA)
"Loss of TBK1 Affects Motor Neuron Autophagy and Disease Progression in a Mouse Model of ALS"
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12:10 pm - 12:15 pm |
Discussion
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12:15 pm - 12:25 pm |
Selected from Poster Abstracts: Daniela Zarnescu (University of Arizona, USA)
"Deciphering Translation Dysregulation Mechanisms Across Multiple Models of ALS"
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12:25 pm - 12:30 pm |
Discussion
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12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
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4:00 pm - 6:00 pm |
Poster Session
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
RNA Granules and Proteinopathies in ALS
Discussion Leader: Christopher Donnelly (University of Pittsburgh, USA)
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7:30 pm - 8:00 pm |
Peter St George-Hyslop (University of Toronto, Canada)
"Modulation of Phase Transition of RNA Binding Proteins in Regulating Protein Expression in Neuronal Termini"
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8:00 pm - 8:10 pm |
Discussion
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8:10 pm - 8:40 pm |
Simon Alberti (Max Planck Institute of Molecular Cell Biology and Genetics, Germany)
"RNP Granules: How They Form, Age and Cause Disease"
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8:40 pm - 8:50 pm |
Discussion
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8:50 pm - 9:20 pm |
Davide Trotti (Thomas Jefferson University, USA)
"Propagation of Disease Linked Poly-Dipeptides in C9orf72-FTD/ALS"
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9:20 pm - 9:30 pm |
Discussion
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Tuesday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Dipeptide and RNA-Mediated Toxicity to Motor Neurons
Discussion Leader: Dieter Edbauer (German Center for Neurodegenerative Diseases (DZNE), Germany)
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9:00 am - 9:35 am |
Andre Hoelz (California Institute of Technology, USA)
"Structure of the Nuclear Pore Complex"
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9:35 am - 9:45 am |
Discussion
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9:45 am - 10:20 am |
James Manley (Columbia University, USA)
"Mechanisms of Gene Expression Dysregulation in ALS"
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10:20 am - 10:30 am |
Discussion
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10:30 am - 11:00 am |
Coffee Break
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11:00 am - 11:35 am |
Justin Ichida (University of Southern California, USA)
"Identification of Therapeutic Targets for ALS Using Phenotypic Chemical and Genetic Screens on Patient-Derived Neurons"
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11:35 am - 11:45 am |
Discussion
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11:45 am - 11:55 am |
Joshua Wheeler (University of Colorado, Boulder, USA)
"Amyloids in Skeletal Muscle"
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11:55 am - 12:00 pm |
Discussion
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12:00 pm - 12:10 pm |
Selected from Poster Abstracts: Anna Corrionero (Massachusetts Institute of Technology / Howard Hughes Medical Institute, USA)
"A C9orf72 ALS/FTD Ortholog Acts in Endolysosomal Degradation and Lysosomal Homeostasis"
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12:10 pm - 12:15 pm |
Discussion
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12:15 pm - 12:25 pm |
Aaron Haeusler (Thomas Jefferson University, USA)
"Modeling Therapeutic Opportunities for Attenuating C9orf72 NRE-Linked Disease"
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12:25 pm - 12:30 pm |
Discussion
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12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
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4:00 pm - 6:00 pm |
Poster Session
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
Emerging Biomarkers of Motor Neuron Disease
Discussion Leader: Nicholas Maragakis (Johns Hopkins University, USA)
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7:30 pm - 8:05 pm |
Frank Bennett (Ionis Pharmaceuticals, USA)
"Antisense Oligonucleotide Therapeutics for Neuromuscular Diseases"
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8:05 pm - 8:15 pm |
Discussion
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8:15 pm - 8:50 pm |
Martin Turner (University of Oxford, United Kingdom)
"System Versus Cell: Pathophysiological Insights from Brain Neuroimaging"
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8:50 pm - 9:00 pm |
Discussion
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9:00 pm - 9:10 pm |
Selected from Poster Abstracts: Eran Hornstein (Weizmann Institute of Science, Israel)
"miRNA Failure in ALS"
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9:10 pm - 9:15 pm |
Discussion
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9:15 pm - 9:25 pm |
Selected from Poster Abstracts: Kaitlin Weskamp (University of Michigan, USA)
"Activity-Dependent Changes in TDP43 Autoregulation and Neuronal Survival in ALS Models"
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9:25 pm - 9:30 pm |
Discussion
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Wednesday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Decoding the Role of TDP-43 and FUS in Neurodegeneration
Discussion Leader: Philip Wong (Johns Hopkins University, USA)
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9:00 am - 9:35 am |
Sami Barmada (University of Michigan, USA)
"Single-Cell TDP43 Homeostasis in Models of Amyotrophic Lateral Sclerosis"
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9:35 am - 9:45 am |
Discussion
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9:45 am - 10:20 am |
James Shorter (University of Pennsylvania, USA)
"Reversing Aberrant Phase Transitions Connected to ALS"
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10:20 am - 10:30 am |
Discussion
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10:30 am - 11:00 am |
Coffee Break
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11:00 am - 11:35 am |
Clotilde Lagier-Tourenne (Harvard Medical School / Massachusetts General Hospital, USA)
"Modeling C9ORF72 Disease: A Crucial Step for Therapeutic Development in ALS/FTD"
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11:35 am - 11:45 am |
Discussion
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11:45 am - 11:55 am |
Selected from Poster Abstracts: John Carson (University of Connecticut Health Center, USA)
"G4C2 Repeat RNA Activates PKR and Inhibits Translation in A2 RNA Granules"
|
11:55 am - 12:00 pm |
Discussion
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12:00 pm - 12:10 pm |
Selected from Poster Abstracts: Udai Pandey (University of Pittsburgh Medical Center, USA)
"Mucleblind Protects Against Neurodegeneration Caused by Pathogenic Mutations in FUS"
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12:10 pm - 12:15 pm |
Discussion
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12:15 pm - 12:25 pm |
Selected from Poster Abstracts: Carlos Castaneda (Syracuse University, USA)
"Liquid-Liquid Phase Separation of ALS-Linked UBQLN2 Is Modulated by Oligomerization and Ubiquitin Binding"
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12:25 pm - 12:30 pm |
Discussion
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12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:00 pm - 7:30 pm |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
7:30 pm - 9:30 pm |
Motor Circuits and Cell Based Systems
Discussion Leader: Fen-Biao Gao (University of Massachusetts Medical School, USA)
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7:30 pm - 8:05 pm |
Siddharthan Chandran (University of Edinburgh, United Kingdom)
"Neuron-Glial Models Systems for Neurodegeneration"
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8:05 pm - 8:15 pm |
Discussion
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8:15 pm - 8:50 pm |
George Mentis (Columbia University, USA)
"Imbalance Between Excitatory and Inhibitory Neurotransmission Causes Motor Neuron Dysfunction in Spinal Muscular Atrophy"
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8:50 pm - 9:00 pm |
Discussion
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9:00 pm - 9:10 pm |
Selected from Poster Abstracts: Ashley Boehringer (Barrow Neurological Institute, USA)
"ALS Associated Mutations in Matrin 3 Alter Protein-Protein Interactions and Impede mRNA Nuclear Export"
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9:10 pm - 9:15 pm |
Discussion
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9:15 pm - 9:25 pm |
Selected from Poster Abstracts: Ke Zhang (Johns Hopkins University, USA)
"Ataxin-2 in Stress Granules Regulates Nucleocytoplasmic Transport in ALS"
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9:25 pm - 9:30 pm |
Discussion
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Thursday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Axons and Glial Cells
Discussion Leader: Richard Ransohoff (Biogen, USA)
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9:00 am - 9:35 am |
Beth Stevens (Boston Children's Hospital, USA)
"How Microglia Prune Synapses in Health and Disease"
|
9:35 am - 9:45 am |
Discussion
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9:45 am - 10:20 am |
Erika Holzbaur (University of Pennsylvania, USA)
"Autophagy Dynamics in Neuronal Homeostasis and Neurodegeneration"
|
10:20 am - 10:30 am |
Discussion
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10:30 am - 11:00 am |
Coffee Break
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11:00 am - 11:35 am |
Richard Robitaille (University of Montreal, Canada)
"Glial Mismanagement of Neuromuscular Junction Structure and Function in ALS"
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11:35 am - 11:45 am |
Discussion
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11:45 am - 11:55 am |
Selected from Poster Abstracts: Karen Ling (Ionis Pharmaceuticals, Inc, USA)
"Evaluating Epha4 as a Therapeutic Target for Amyotrophic Lateral Sclerosis by Antisense-Mediated Inhibition in the Adult Mouse CNS"
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11:55 am - 12:00 pm |
Discussion
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12:00 pm - 12:10 pm |
Selected from Poster Abstracts: Krista Spiller (Center for Neurodegenerative Disease Research, University of Pennsylvania, USA)
"Microglia-Mediated Recovery from Motor Neuron Degeneration"
|
12:10 pm - 12:15 pm |
Discussion
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12:15 pm - 12:25 pm |
Selected from Poster Abstracts: Jonathan Grima (Johns Hopkins University, USA)
"The Nuclear Pore Complex Is Compromised in ALS"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
From Big Data Analysis to Therapeutics
Discussion Leader: Kenneth Fischbeck (National Institute of Neurological Disorders and Stroke, NIH, USA)
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7:30 pm - 8:00 pm |
Ernest Fraenkel (Massachusetts Institute of Technology, USA)
"Integrating Transcriptional, Epigenomic and Proteomic Data to Reveal Pathways Altered by Mutated C9ORF72 in iPSC-Derived Motor Neurons"
|
8:00 pm - 8:10 pm |
Discussion
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8:10 pm - 8:40 pm |
Leonard Petrucelli (Mayo Clinic College of Medicine and Science, USA)
"Mechanistic and Therapeutic Insights into C9ALS"
|
8:40 pm - 8:50 pm |
Discussion
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8:50 pm - 9:20 pm |
Matthew Disney (The Scripps Research Institute, USA)
"Design of Small Molecules Targeting Repeating Transcripts"
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9:20 pm - 9:30 pm |
Discussion
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Friday
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7:30 am - 8:30 am |
Breakfast
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9:00 am |
Departure
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