Sunday 
 
 
2:00 pm - 9:00 pm 
	
Arrival and Check-in
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 7:40 pm 
	
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
 
 
						
7:40 pm - 9:30 pm 
	
Clinical Phenotypes in ALS and Related Motor Neuron Diseases 
 
 
 
						
7:40 pm - 7:50 pm 
	
Opening Remarks
 
 
						
7:50 pm - 8:15 pm 
	
"Neuroanatomic Neuropathologic Correlations with ALS Phenotypes" 
 
 
 
						
8:15 pm - 8:20 pm 
	
Discussion
 
 
						
8:20 pm - 8:45 pm 
	
"Current and Future Therapeutic Interventions in SMA" 
 
 
 
						
8:45 pm - 8:50 pm 
	
Discussion
 
 
						
8:50 pm - 9:15 pm 
	
"Accelerating Therapy Development: Master Platform Trial Initiatives and Subgroups" 
 
 
 
						
9:15 pm - 9:20 pm 
	
Discussion
 
 
						
9:20 pm - 9:30 pm 
	
General Discussion
 
 
						
	Monday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 12:30 pm 
	
Axonal Biology and Motor Neuron Loss 
 
 
 
						
9:00 am - 9:25 am 
	
"Nuclear Transport Receptors as Regulators of Protein Aggregation and Toxicity in ALS" 
 
 
 
						
9:25 am - 9:30 am 
	
Discussion
 
 
						
9:30 am - 9:55 am 
	
"Regulation of Axonal Protein Synthesis by G3BP1 Aggregation" 
 
 
 
						
9:55 am - 10:00 am 
	
Discussion
 
 
						
10:00 am - 10:25 am 
	
"Axonal Transport Defects in iPSC-Derived Motor Neurons" 
 
 
 
						
10:25 am - 10:30 am 
	
Discussion
 
 
						
10:30 am - 11:00 am 
	
Coffee Break
 
 
						
11:00 am - 11:25 am 
	
"A Surprising Link Between Lysosomal and RNA Biology in ALS Pathogenesis" 
 
 
 
						
11:25 am - 11:30 am 
	
Discussion
 
 
						
11:30 am - 11:55 am 
	
"ALS FUS Mutations Alter Splicing and Translation Through Loss and Gain of Function" 
 
 
 
						
11:55 am - 12:00 pm 
	
Discussion
 
 
						
12:00 pm - 12:10 pm 
	
"Decoding Motor Axon Biology in Health and ALS Using Axon-Seq" 
 
 
 
						
12:10 pm - 12:15 pm 
	
Discussion
 
 
						
12:15 pm - 12:30 pm 
	
General Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Role of RNA Binding Proteins in Motor Neuron Degeneration 
 
 
 
						
7:30 pm - 7:55 pm 
	
"Therapy Development for Disease from TDP-43 Loss and/or Gain-of-Function" 
 
 
 
						
7:55 pm - 8:00 pm 
	
Discussion
 
 
						
8:00 pm - 8:25 pm 
	
"Pathological TDP-43 Assemblies and Their Link to Disease Heterogeneity" 
 
 
 
						
8:25 pm - 8:30 pm 
	
Discussion
 
 
						
8:30 pm - 8:55 pm 
	
"ALS and RNA: Thinking Outside the Nuclear Box" 
 
 
 
						
8:55 pm - 9:00 pm 
	
Discussion
 
 
						
9:00 pm - 9:10 pm 
	
"Pathological Alterations of the Spinal Motor Neurons Induced by Optogenetic TDP-43 Oligomerization" 
 
 
 
						
9:10 pm - 9:15 pm 
	
Discussion
 
 
						
9:15 pm - 9:25 pm 
	
"Phosphorylation Disrupts hnRNPA2 Aggregation and Alters Interactions with mRNA Transport Granule Components" 
 
 
 
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						
	Tuesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
8:30 am - 9:00 am 
	
Group Photo
 
 
						
9:00 am - 12:30 pm 
	
Mechanisms of Aberrant RNA Metabolism 
 
 
 
						
9:00 am - 9:25 am 
	
"Production and Toxicity of Poly(GR) in C9ORF72-ALS/FTD" 
 
 
 
						
9:25 am - 9:30 am 
	
Discussion
 
 
						
9:30 am - 9:55 am 
	
"Disassembly and Reassembly of the Nuclear Pore Complex in ALS/FTD" 
 
 
 
						
9:55 am - 10:00 am 
	
Discussion
 
 
						
10:00 am - 10:25 am 
	
"Therapeutic Targeting of RNA in Spinal Muscular Atrophy" 
 
 
 
						
10:25 am - 10:30 am 
	
Discussion
 
 
						
10:30 am - 11:00 am 
	
Coffee Break
 
 
						
11:00 am - 11:25 am 
	
"Molecular Mechanisms Controlling Localization and Phase Separation of ALS-Linked RNA-Binding Proteins" 
 
 
 
						
11:25 am - 11:30 am 
	
Discussion
 
 
						
11:30 am - 11:55 am 
	
"Pathogenic Mutations in Gemin5 Cause Early-Onset Motor Dysfunction and Cerebellar Atrophy and Disrupt snRNP Complex" 
 
 
 
						
11:55 am - 12:00 pm 
	
Discussion
 
 
						
12:00 pm - 12:10 pm 
	
"ADAR2 Mislocalization and Widespread RNA Editing Aberrations in C9orf72-Mediated ALS/FTD" 
 
 
 
						
12:10 pm - 12:15 pm 
	
Discussion
 
 
						
12:15 pm - 12:30 pm 
	
General Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Role of Proteinopathies in Motor Neuron Disease 
 
 
 
						
7:30 pm - 7:55 pm 
	
"Cellular and Molecular Basis of Motor Neuron Demise: From SBMA to ALS" 
 
 
 
						
7:55 pm - 8:00 pm 
	
Discussion
 
 
						
8:00 pm - 8:25 pm 
	
"Exploiting the Androgen Receptor Interactome to Identify Pathogenic Mechanisms in SBMA" 
 
 
 
						
8:25 pm - 8:30 pm 
	
Discussion
 
 
						
8:30 pm - 8:55 pm 
	
"Protein Quality Control of Membraneless Organelles: Implications in ALS and Neurodegenerative Diseases" 
 
 
 
						
8:55 pm - 9:00 pm 
	
Discussion
 
 
						
9:00 pm - 9:10 pm 
	
"Investigating the Mechanisms of UPF1-Mediated Rescue of TDP-43 Toxicity" 
 
 
 
						
9:10 pm - 9:15 pm 
	
Discussion
 
 
						
9:15 pm - 9:25 pm 
	
"ALS-Implicated Protein TDP-43 Sustains Levels of STMN2, a Mediator of Motor Neuron Growth and Regeneration" 
 
 
 
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						
	Wednesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 12:30 pm 
	
Aberrant Protein Control and Related Mechanisms 
 
 
 
						
9:00 am - 9:25 am 
	
"The Nucleolus as a Protein Quality Control Compartment" 
 
 
 
						
9:25 am - 9:30 am 
	
Discussion
 
 
						
9:30 am - 9:55 am 
	
"Role of the Autophagy Inducing Kinases, ULK1 and ULK2, in Degenerative Disorders" 
 
 
 
						
9:55 am - 10:00 am 
	
Discussion
 
 
						
10:00 am - 10:25 am 
	
"Loss of Nuclear TDP-43 Function as a Mechanism of ALS Pathogenesis" 
 
 
 
						
10:25 am - 10:30 am 
	
Discussion
 
 
						
10:30 am - 11:00 am 
	
Coffee Break
 
 
						
11:00 am - 11:25 am 
	
"Linking Selective Autophagy to Neurodegenerative Disease" 
 
 
 
						
11:25 am - 11:30 am 
	
Discussion
 
 
						
11:30 am - 11:55 am 
	
"Latest Insights from Amyloid Structures: Steric Zippers and LARKS in Fibrils" 
 
 
 
						
11:55 am - 12:00 pm 
	
Discussion
 
 
						
12:00 pm - 12:10 pm 
	
"The RNA Composition of Tau Aggregates in a Cellular Model of FTD" 
 
 
 
						
12:10 pm - 12:15 pm 
	
Discussion
 
 
						
12:15 pm - 12:30 pm 
	
General Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:00 pm - 7:30 pm 
	
Business Meeting 
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair 
 
 
						
7:30 pm - 9:30 pm 
	
Role of Neuroinflammation in Neurodegeneration 
 
 
 
						
7:30 pm - 7:55 pm 
	
"Three Subtypes of ALS: Retrotransposons, Stress and Inflammation" 
 
 
 
						
7:55 pm - 8:00 pm 
	
Discussion
 
 
						
8:00 pm - 8:25 pm 
	
"Microglial Toxicity and TDP-43 Proteinopathy in Neurodegeneration" 
 
 
 
						
8:25 pm - 8:30 pm 
	
Discussion
 
 
						
8:30 pm - 8:55 pm 
	
"The Role and Mechanism of RIPK1 in Mediating Neuroinflammation and Cell Death in ALS" 
 
 
 
						
8:55 pm - 9:00 pm 
	
Discussion
 
 
						
9:00 pm - 9:10 pm 
	
"C9orf72 Functions to Suppress Systemic and Neural Inflammation Induced by Gut Microbiota" 
 
 
 
						
9:10 pm - 9:15 pm 
	
Discussion
 
 
						
9:15 pm - 9:25 pm 
	
"Effects of Heterozygous Tbk1 Deletion in Old or Mutant SOD1 Transgenic Mice" 
 
 
 
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						
	Thursday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 12:30 pm 
	
Glial Biology of Motor Neuron Diseases 
 
 
 
						
9:00 am - 9:25 am 
	
"What Do Reactive Astrocytes (Actually) Do?" 
 
 
 
						
9:25 am - 9:30 am 
	
Discussion
 
 
						
9:30 am - 9:55 am 
	
"Astrocyte Hemichannels as Conduits for Motor Neuron Death in ALS" 
 
 
 
						
9:55 am - 10:00 am 
	
Discussion
 
 
						
10:00 am - 10:25 am 
	
"Stage Specific Control of Oligodendrocytes by TDP-43" 
 
 
 
						
10:25 am - 10:30 am 
	
Discussion
 
 
						
10:30 am - 11:00 am 
	
Coffee Break
 
 
						
11:00 am - 11:25 am 
	
"Glial Involvement in Synapse Loss in Alzheimer's Disease and ALS: Evidence from Human Post-Mortem Brain" 
 
 
 
						
11:25 am - 11:30 am 
	
Discussion
 
 
						
11:30 am - 11:40 am 
	
"C9orf72 Deficiency Promotes Microglial Mediated Synaptic Loss in Aging or Amyloid Accumulation" 
 
 
 
						
11:40 am - 11:45 am 
	
Discussion
 
 
						
11:45 am - 11:55 am 
	
"Using Patient-Derived Astrocytes to Inform Precision Medicine Approaches" 
 
 
 
						
11:55 am - 12:00 pm 
	
Discussion
 
 
						
12:00 pm - 12:10 pm 
	
"Single Cell RNA Sequencing Uncovers Disease Associated Changes in the Population Structure of Human Microglia Specific to Amyotrophic Lateral Sclerosis" 
 
 
 
						
12:10 pm - 12:15 pm 
	
Discussion
 
 
						
12:15 pm - 12:30 pm 
	
General Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Experimental Therapeutics and Biomarkers 
 
 
 
						
7:30 pm - 7:55 pm 
	
"The New Frontier of Spinal Muscular Atrophy: When, Where and How to Mitigate a Neurodegenerative Disease" 
 
 
 
						
7:55 pm - 8:00 pm 
	
Discussion
 
 
						
8:00 pm - 8:25 pm 
	
"RNA-Targeted Mechanisms and Therapeutics for ALS" 
 
 
 
						
8:25 pm - 8:30 pm 
	
Discussion
 
 
						
8:30 pm - 8:55 pm 
	
"Transforming Target Identification for Neurodegenerative Diseases: Proof of Concept in Synucleinopathies and Progress in ALS" 
 
 
 
						
8:55 pm - 9:00 pm 
	
Discussion
 
 
						
9:00 pm - 9:15 pm 
	
General Discussion
 
 
						
9:15 pm - 9:30 pm 
	
Closing Remarks
 
 
						
	Friday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am 
	
Departure