Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: The Complexity of the RAAS From Molecules to Organ Systems
Discussion Leaders: Mariane Bertagnolli (McGill University, Canada) and Michael Bader (Max Delbrück Center for Molecular Medicine, Germany)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
Robson Santos (Federal University of Minas Gerais, Brazil)
"The Endless Story of Angiotensins: Partial Characterization of a New Angiotensin with Unexpected Activities"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Louise Burrell (University of Melbourne, Australia)
"Systems Medicine and the RAAS: From Rare Diseases to Multimorbidity"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Biology of the RAAS
Discussion Leaders: Ulrich Wenzel (Universitätsklinikum Hamburg Eppendorf, Germany) and Sabrina Gonsalez (Erasmus MC, The Netherlands)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Pedro Barcelos (University of São Paulo, Brazil)
"Autoantibodies Targeting GPCRs and RAAS-Related Molecules in Health and Disease"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Tracy Williams (Ludwig Maximilian University of Munich, Germany)
"Spatial Omics Profiling of Aldosterone-Producing Adrenal Lesions"
10:00 am - 10:10 am
Discussion
10:10 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Claudio Costa-Neto (University of Sao Paulo, Brazil and Jeito Capital , Brazil)
"AT1R: Regulation, Tachyphylaxis, and Signaling"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Ariel Gomez (University of Virginia, United States)
"Development and Fate of Renin Cells in Health and Disease"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Arya Mani (Yale University, United States)
"PRDM6 a Key Epigenetic Regulator of Renin and its Deficiency Leads to Salt-Induced Hypertension"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Evany Dinakis (Monash University, Australia)
"pH-Sensor GPR68 Plays a Role in the Cardioprotective Effects of a High Fibre Diet"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Leonie Dreher (University Medical Center Hamburg, Germany, Germany)
"Deficiency of the Complement Receptor C5aR2 has no Effect on Blood Pressure and End Organ Damage in Angiotensin II Induced Hypertension"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Jane Reckelhoff (University of Mississippi Medical Center, United States) and Nara Gavini (MGH Institute of Health Professions & Harvard Medical School, United States)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
New Insights into RAAS Components
Discussion Leaders: Minolfa Prieto (Tulane University, United States) and Alexander Pinto (Baker Heart and Diabetes Institute, Australia)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Thiago Verano-Braga (Universidade Federal de Minas Gerais, Brazil)
"Renin-Angiotensin System and Gut Microbiome: Unveiling a New Functional Axis"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Vsevolod Katritch (University of Southern California, United States)
"Discovery and Development of Novel AT2R Ligands From Structure-Based Giga-Scale Virtual Screening"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Lachlan Schofield (University of Newcastle, Australia)
"The Soluble Prorenin Receptor Promotes a Preeclamptic-Like Phenotype In-Vivo"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Catherine Llorens-Cortes (CEA Paris-Saclay and College de France, INSERM U1050 Paris, France)
"Metabolically Stable Apelin Analogs : Development and Functional Role in Water Balance and Cardiovascular Function"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Daniel Fehrenbach (Indiana University School of Medicine, United States)
"Immune Activation Promotes Cardiac Remodeling in a Mouse Model of Takotsubo Cardiomyopathy and Potentiates Hypertensive Response to Angiotensin II"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Networking Between the RAAS and Other Systems
Discussion Leaders: Dulce Casarini (Universidade Federal de Sao Paulo, Brazil) and Daniela Carnevale (Sapienza University of Rome and IRCCS Neuromed, Italy)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Diana Karpman (Lund University, Sweden)
"Cross-Talk Between the RAAS, Kallikrein-Kinin and Complement Systems in Inflammation"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Augusto Montezano (Research Institute of the McGill University Health Centre - RIMUHC, Canada)
"Cross Talk Between the Ang-(1-7)/Mas and The Endothelin-1 System"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Igor Souza-Silva (University of Southern Denmark, Denmark)
"Characterisation of the Molecular Interactions Between Angiotensin-(1-5) and the Angiotensin AT2-Receptor"
10:20 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Patrick Rothwell (University of Minnesota, United States)
"Angiotensin and the Opioid System"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Annet Kirabo (Vanderbilt University Medical Center, United States)
"Immune RAAS in Salt-Sensitive Hypertension"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Mariela Gironacci (Universidad de Buenos Aires, Argentina)
"Masr-Mrgdr Heteromerization Mediates the Anti-Inflammatory Response of Almandine in Human Macrophages"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Ahmet Kuralay (University of iowa, United States)
"Afferent Regulation of Hindbrain Aldosterone-Sensing Neurons by the Central Amygdala"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Aldosterone, Mineralocorticoid Receptors, and Signaling
Discussion Leaders: Gian Paolo Rossi (University of Padua, Italy) and Romer Gonzalez Villalobos (Johnson & Johnson Innovative Medicine, United States)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Frederic Jaisser (National Institute of Health and Medical Research (INSERM), France)
"Mineralocorticoid Receptors in Cardiorenal Disease"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Maria-Christina Zennaro (Inserm, Université Paris Cité, France)
"Deciphering the Genetic Spectrum: From Aldosterone Dysregulation to Primary Aldosteronism"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
David Rodman (Mineralys Therapeutics, United States)
"Translational Development of the Selective CYP11B2 Inhibitor, Lorundrostat: Pre-clinical and Phase 1 PK/PD Modeling Through Successful Proof-of-Concept in Subjects with Uncontrolled and Resistant HTN"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Melania Aluia (University Medical Center of the Johannes Gutenberg–University Mainz, Germany, Germany)
"Conditional Over-Expression of Heme-Oxygenase 1 in Myelomonocytic Cells Reduces AngII-Induced Hypertension and Vascular Inflammation in Mice"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Kengo Azushima (Yokohama City University Graduate School of Medicine, Japan)
"Angiotensin II Receptor-Associated Protein in the Skin Regulates Blood Pressure via Modulating Skin Renin-Angiotensin System Activity"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
RAAS, Metabolism, and Diabetes: Novel Paradigms
Discussion Leaders: Francine Marques (Monash University, Australia) and Pablo Nakagawa (Medical College of Wisconsin, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Naima Moustaid-Moussa (Texas Tech University, United States)
"The Adipocyte RAAS: From Metabolic Diseases to Cancer"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Jan Danser (Erasmus MC, The Netherlands)
"Synergistic Effects of SGLT2 Inhibition and RAS Blockade in Experimental Diabetes"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Loïs van der Pluijm (Leiden UMC, The Netherlands)
"SGLT2 Inhibition Promotes Glomerular Repopulation by Cells of Renin Lineage in Experimental Kidney Disease"
10:20 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Hannah Costello (University of Florida, United States)
"Integrative Physiology of the RAAS and Circadian Clock in Sex Differences and Cardiovascular Function"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Yasir Alsiraj (University of Kentucky, United States)
"Role of the X Chromosome Gene, Kdm5c, in Sexual Dimorphism of AngII-Induced Aortopathies"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Robert Widdop (Monash University, Australia)
"Role of AT2 R in the Reno-Protective Effects of Pharmacological Inhibition or Genetic Deficiency of Insulin Regulated Aminopeptidase (IRAP) in UUO-Induced Renal Injury in Mice"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Hanxue Wu (Xi’an Jiaotong University, China)
"Targeting Brain Renin-Angiotensin System Reveals Pivotal Role of Hippocampal Inflammation in Hypertension-Associated Cognitive Impairment"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cell Senescence, Inflammation, Aging, and the RAAS
Discussion Leaders: Maria Luisa Sequeira-Lopez (University of Virginia, United States) and Satoru Eguchi (Lewis Katz School of Medicine at Temple University, United States)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Concepción (Concha) Peiró (Universidad Autónoma de Madrid, Spain)
"Angiotensin-(1-7) and Endothelial Cell Senescence"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Anton Roks (Erasmus Medical Center, The Netherlands)
"Angiotensin II and Renin in Aging"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Jennifer DuPont (Tufts Medical Center, United States)
"Sex Differences in the Role of Angiotensin II Receptors in Vascular Aging"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Daniela Carnevale (Sapienza University of Rome and IRCCS Neuromed, Italy)
"Neural Circuits Regulate the Immune Response in Cardiovascular Disease"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Drug Discovery Targeting the RAAS and New Therapeutic Approaches
Discussion Leaders: Marko Poglitsch (Covirabio, Austria) and Michel Azizi (Université Paris Cité, Hôpital Européen Georges Pompidou, France)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Martine Clozel (Idorsia Pharmaceuticals Ltd, Switzerland)
"Beyond RAAS Blockade: Targeting the Endothelin System in Hypertension: Is There An Added Benefit?"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Andrew Kruse (Harvard Medical School, United States)
"Structural Basis for Antibody Fragment Modulation of Angiotensin Receptor Signaling"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Adam Misák (Semmelweis University, Hungary)
"AT1R Ligand Binding Mechanism Characterization With Well-Tempered Metadynamics"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Ed Sturrock (University of Cape Town, South Africa)
"Changing Paradigms in ACE Blockade: From Competitive to Allosteric Inhibition"
11:10 am - 11:20 am
Discussion
11:20 am - 11:30 am
Filip Hanak (University of Minnesota, United States)
"N-domain Inhibition of the Angiotensin-converting Enzyme is Sufficient to Elevate Concentrations of Met-Enkephalin-Arg-Phe in Brain Tissue"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
Monica Santisteban (Vanderbilt University Medical Center, United States)
"IL17 Modulates the Cerebrovascular Effects of Angiotensin II in DOCA-Salt Hypertension"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Lorenzo Carnevale (I.R.C.C.S. Neuromed, Italy)
"RAAS Targeting Antihypertensive Strategies Have Different Impact on the Cerebral Injury Pattern in Hypertensives"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Kirsty Pringle (University of Newcastle, Australia)
"Targeting the Protective Actions of ACE2 in Pregnancies with Fetal Growth Restriction"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Translating RAAS Drug Discovery to Clinical Impact
Discussion Leaders: Ulrike (Muscha) Steckelings (University of Southern Denmark, Denmark) and Annet Kirabo (Vanderbilt University Medical Center, United States)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:45 pm
Zorina Galis (National Institutes of Health, United States)
"Making Translational Research a Reality: How Can We Do Better?"
6:45 pm - 6:55 pm
Discussion
6:55 pm - 7:30 pm
Dominik Muller (Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Germany)
"Sustainable Research and the Future of Angiotensin Research"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:50 pm
General Discussion
7:50 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure