Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Antibodies 2.0
Discussion Leader: Rob de Jong (Genmab, The Netherlands)
7:40 pm - 8:20 pm
Tomoyuki Igawa (Chugai Pharmaceutical Co., Ltd., Japan)
"Design of Antibody Therapeutics with Engineered Multispecificity"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Katherine Vallis (University of Oxford, United Kingdom)
"Cell-Penetrating Peptide-Mediated Internalisation of Antibodies for Radioimmunotherapy of Pancreatic Cancer"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Anti-Infectious Repertoires and Therapeutics
Discussion Leader: James Crowe (Vanderbilt University Medical Center, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Pascal Chappert (Institut Necker-Enfants Malades, France)
"Evolution of Human B Cell Memory Over Time and Repeated Antigenic Encounters"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Jorge Dias (Alchemab Therapeutics, United Kingdom)
"Antibody Repertoire Analysis: A Novel Route to Target Discovery"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Natalia Freund (Tel Aviv University, Israel)
"Complexity Matters: How Natural Antibodies Eliminate Complex Pathogens"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
Late-Breaking Topic
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Short Talk Selected from Poster Abstracts
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Seble Asrat (Regeneron Pharmaceuticals, United States)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Antibody Delivery
Discussion Leader: James Ernst (Xencor Inc., United States)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
Kathryn Monroe (Denali Therapeutics, United States)
"A TREM2-Activating Antibody with a Blood–Brain Barrier Transport Vehicle Enhances Microglial Metabolism in Alzheimer’s Disease Models"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
Matthew Holt (Instituto de Investigação e Inovação em Saúde , Portugal)
"Bypassing the Blood Brain Barrier: Exploiting CNS Penetrant AAV Vectors for Localised Biologics Production and Activity"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Short Talk Selected from Poster Abstracts
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Short Talk Selected from Poster Abstracts
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Short Talk Selected from Poster Abstracts
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Abs Formats for Cancer and Autoimmunity
Discussion Leader: Matthew Sleeman (Regeneron Pharmaceuticals, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Eric Viver (Innate Pharma, France)
"Natural Killer Cell Engagers"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Jamie Rich (Zymeworks Inc., Canada)
"Engineering More Stable Antibody Drug Conjugates to Address Platform Toxicities is Conceptually Simple but Hard to Translate to the Clinic"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Georg Schett (Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany)
"CAR-T Cell Therapy in Autoimmune Diseases"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
Late-Breaking Topic
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Short Talk Selected from Poster Abstracts
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
IgG4 Therapeutics
Discussion Leader: Jenna Guthmiller (University of Colorado Anschutz Medical Campus, United States)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
Maartje Huijbers (Leiden University Medical Center, The Netherlands)
"The Unique Properties of IgG4 and its Roles in Health and Disease"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
Shirley Peters (UCB, United Kingdom)
"Development of Anti-FcRn Antibodies for Blocking FcRn in Autoimmune Diseases"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Short Talk Selected from Poster Abstracts
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Short Talk Selected from Poster Abstracts
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Short Talk Selected from Poster Abstracts
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Engineering Abs for Enhanced Function
Discussion Leader: David Humphreys (UCB-Pharma, United Kingdom)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Liqiang Pan (Zhejiang University, China)
"TCR-Mimic Nanobody-Based Bispecific T Cell Engager for Tumor Immunotherapy"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Steve Dunham (Zoetis, Inc, United States)
"The Evolution of Antibody Discovery in Veterinary Medicine"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Rob de Jong (Genmab, The Netherlands)
"Mutually Dependent Antibody Pairs that Selectively act on Cells Co-Expressing two Surface Antigens"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
Late-Breaking Topic
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Short Talk Selected from Poster Abstracts
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Plasma Cell Responses
Discussion Leader: Natalia Freund (Tel Aviv University, Israel)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
Ali Ellebedy (Washington University School of Medicine, United States)
"Germinal Center-Driven Maturation of B Cell Responses to Vaccination"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
Seble Asrat (Regeneron Pharmaceuticals, United States)
"High-Throughput Profiling of Antigen-Specific Antibody Secreting Cells"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Short Talk Selected from Poster Abstracts
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Short Talk Selected from Poster Abstracts
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Short Talk Selected from Poster Abstracts
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Computational and Systems Analyses
Discussion Leader: Lawrence Wang (University of California San Diego, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Kendra Avery (Xencor, United States)
"Discovery and Characterization of CD28 Multispecific Antibodies for Treatment of Solid Tumors"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Lenette Lu (UT Southwestern Medical Center, United States)
"Dissecting Antibody Functions in Tuberculosis"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
James Crowe (Vanderbilt University Medical Center, United States)
"Human Antibodies for Emerging Infectious Diseases"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
Late-Breaking Topic
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Short Talk Selected from Poster Abstracts
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Vaccination Shapes B and Ab Responses
Discussion Leader: Lenette Lu (UT Southwestern Medical Center, United States)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
Davide Corti (Humabs BioMed, Vir Biotechnology, Switzerland)
"The Past, Present and Future of Antiviral Monoclonal Antibodies"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
Michael Meyer-Hermann (Helmholtz Centre for Infection Research, Germany)
"How to Employ Antibodies to Make Antibodies Broadly Neutralizing"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Short Talk Selected from Poster Abstracts
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Short Talk Selected from Poster Abstracts
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Short Talk Selected from Poster Abstracts
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure