Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Keynote Session: Structure-Guided Immunogen Design
Discussion Leader: Jenna Guthmiller (University of Colorado Anschutz Medical Campus, United States)
3:15 pm - 3:50 pm
Andrew Ward (The Scripps Research Institute, United States)
"CryoEM Pipeline for Antibody Discovery and Characterization"
3:50 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Antibody-Based Methodologies and Technologies
Discussion Leader: Joshua Tan (NIAID, United States)
5:30 pm - 5:45 pm
Habib Bashour (University of Oslo (UiO), Norway)
"Biophysical Cartography of the Native and Human-Engineered Antibody Landscapes Quantifies the Plasticity of Antibody Developability"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:05 pm
Megan DeMouth (Albert Einstein College of Medicine, United States)
"Camoolids: Miniaturized Single-Domain Bispecifics From Natural Camelid and Bovine Antibody Repertoires"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
James Ferguson (Scripps Research, United States)
"Modelangelo in Action: An Integrative Analysis for Rapid Monoclonal Antibody Identification and Characterization from cryoEM of Polyclonal Serum"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
Nicholas Till (Stanford University, United States)
"TrogoTACs: Bispecific Chimeras for Targeted Protein Transfer"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Barnabas Nyesiga (Malmö University and Alligator Bioscience, Sweden)
"A Tetravalent (2+2) Bispecific Antibody Format With Excellent Functionality and IgG-Like Stability, Pharmacology and Developability Properties"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Isaiah Shriner (Harvard Medical School / Ragon Institute, United States)
"Engineering Trojan Horse Nanoparticles for Targeted Endosomal Delivery of Viral Fusion Inhibitors"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Diagnostic and Therapeutic Applications of Antibodies
Discussion Leaders: Pierre Bruhns (Institut Pasteur, France) and Natalia Freund (Tel Aviv University, Israel)
9:00 am - 9:15 am
Rachael Wolters (Vanderbilt University, United States)
"A Mechanistic Understanding of Protective Influenza B Neuraminidase mAbs at the Airway Interface"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Devivasha Bordoloi (The Wistar Institute, USA, United States)
"Novel Biologics Targeting Human Siglec-7: Potential Tools for Ovarian Cancer Immunotherapy"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Dana Thornlow (Ragon Institute of MGH, MIT and Harvard, United States)
"Designing Hyperglycosylated Hemagglutinin Beads-On-A-String (BoaS) Immunogens for Epitope-Focused Influenza Vaccines"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Jordan Barrett (The Scripps Research Institute, United States)
"High-Throughput Characterisation of Human Anti-PfRH5 Antibodies Reveals a Potent Public Antibody Clonotype Against Blood-Stage Malaria"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Ty Sornberger (Vanderbilt University, United States)
"Characterization of a Heterosubtypic Influenza Antibody Lineage Targeting the Neuraminidase Active Site"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Alicia Chenoweth (King's College London, United Kingdom)
"Fc Engineered Monoclonal Antibodies for Triple Negative Breast Cancer Therapy"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: What’s Next: Choosing the Optimal Career Path
Discussion Leader: Andrew Ward (The Scripps Research Institute, United States)
1:30 pm - 2:30 pm
Panel Discussion
What's Next: Choosing the Optimal Career Path
Pierre Bruhns (Institut Pasteur, France)
Jenna Guthmiller (University of Colorado Anschutz Medical Campus, United States)
Joshua Tan (NIAID, United States)
Natalia Freund (Tel Aviv University, Israel)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes