| Sunday Night March 18 |
| 2:00-9:00 PM | Arrival and Registration |
| 6:00 PM | Dinner |
| 7:30-9:30 PM | Keynote Session |
| Discussion Leaders: Chuck Bevins and Bob Hancock |
| Welcome: Chuck Bevins
Introduction: Bob Hancock |
| Keynote Address:
Jules Hoffmann "Innate immunity : evolutionary perspectives." (50 minutes)
|
| Monday AM March 19 |
| 7:30-8:30 AM | Breakfast |
| 8:30 AM | CONFERENCE PHOTO |
| 9:00AM-12:30PM | Activities and Mechanisms: Membrane Interactions |
| Discussion Leaders: Hans Georg Sahl and Yechial Shai |
| 9-9:20 | Huey Huang Action of Antimicrobial Peptides: two-state model. |
| 9:30-9:50 | Margherita Dathe Membrane-Peptide Interactions |
| 10:00-10:30 | Coffee |
| 10:30-10:50 | Katsumi Matsuzaki Mechanisms of synergism between antimicrobial peptides |
| 11:00-11:20 | Sun Chang Kim The killing of microorganisms by penetrating the cell membrane and inhibiting cellular functions |
| 11:30-11:50 | Hans Vogel The structures of micelle-bound tritrpticin and related tryptophan-rich antimicrobial peptides |
| 12:00-12:15 | Selected Poster "Short Talks" |
| 12:15-12:30 | Session Discussion |
| Monday PM March 19 |
| 1:30-4:00 PM | Free of all formal activity |
| 4:30-6:00 PM | Poster Session A |
| 6:00-7:00 PM | Dinner |
| Mechanisms of Innate Immunity |
| Discussion Leaders: Philippe Bulet and Dan Hultmark |
| 7:30-7:50 | Austin Hughes Evolutionary derivation of molecules that define adaptive immunity |
| 8:00-8:20 | Jean Luc Imler Toll signalling pathways in innate immunity |
| 8:30-8:50 | Gill Diamond Innate Immune Pathways and Defensin Gene Expression in the Airway Epithelium |
| 9:00-9:20 | Monisha Scott Antimicrobial peptides cause transcriptional up-regulation of multiple genes in macrophages |
| 9:30-9:45 | Selected Poster "Short Talks" |
| 9:45-10:00 | Session Discussion |
| Tuesday AM March 20 |
| 7:30-8:30 AM | Breakfast |
| 9:00AM-12:30PM | Biology and Regulation |
| Discussion Leaders: Tomas Ganz and Margherita Zanetti |
| 9-9:20 | Svenja Stöven Relish, a central factor in insect humoral immunity |
| 9:30-9:50 | Carole Wilson Proteolytic Modification of Beta-defensins by the Metalloproteinase Matrilysin |
| 10:00-10:30 | Coffee |
| 10:30-10:50 | Mike Yeaman Microbicidal Proteins from Platelets |
| 11:00-11:20 | Joe Oppenheim Receptor mediated signalling by defensins |
| 11:30-11:50 | Gallo, Richard Cathelicidins in Cutaneous Defense |
| 12:00-12:15 | Selected Poster "Short Talks" |
| 12:15-12:30 | Session Discussion |
| Tuesday PM March 20 |
| 1:30-4:00 PM | Free of all formal activity |
| 4:30-6:00 PM | Poster Session A (Cont'd) |
| 6:00-7:00 PM | Dinner |
| Peptide Structure and Novel Methodology |
| Discussion Leaders: Jules Hoffman and Bob Lehrer |
| 7:30-7:50 | Mike Selsted Theta defensins |
| 8:00-8:20 | Bob Hodges Gramicidin like peptides |
| 8:30-8:50 | Paul McCray Genomics Approach to Identifying Novel Defensins |
| 9:00-9:20 | Hans-Henrik Kristensen A High Throughput System for Identifying Antibiotic Peptides |
| 9:30-9:45 | Selected Poster "Short Talks" |
| 9:45-10:00 | Session Discussion |
| Wednesday AM March 21 |
| 7:30-8:30 AM | Breakfast |
| 9:00AM-12:30PM | Pathogenesis: The Bugs Fight Back |
| Discussion Leader: Bill Shafer and Sam Miller |
| 9-9:20 | Sam Miller Overview
|
| 9:30-9:50 | Fritz Gotz Relationship between bacterial cell wall change, antimicrobial peptide resistence, and virulence. |
| 10:00-10:30 | Coffee |
| 10:30-10:50 | Jeff Weiser Adaptation by Respiratory Pathogens to Innate Immunity |
| 11:00-11:20 | Pablo Rodriguez-Palenzuela Unveiling common features in plant and animal bacterial pathogenesis. |
| 11:30-12:00 | Selected Poster "Short Talks" |
| 12:00-12:30 | Session Discussion |
| Wednesday PM March 21 |
| 1:30-4:00 PM | Free of all formal activity |
| 4:30-6:00 PM | Poster Session B |
| 6:00-7:00 PM | Dinner |
| New Perspectives on Biological Activities and Function |
| Discussion Leader: Andy Oullette and Mike Selsted |
| 7:30-7:50 | Beverly Dale-Crunk Defensins in the oral environment |
| 8:00-8:20 | Jens Schroder Antimicrobial peptides of human skin: Bacterial Induction and Regulation |
| 8:30-8:50 | Birgitta Agerberth Perspectives on LL37 biology. |
| 9:00-9:20 | Robert Bals Augmentation of innate host defense |
| 9:30-9:45 | Selected Poster "Short Talks" |
| 9:45-10:00 | Session Discussion |
| Thursday AM March 22 |
| 7:30-8:30 AM | Breakfast |
| 9:00AM-12:30PM | Controversies In Antimicrobial Peptides: |
| Attendees are invited to express their opinions in less than 5 minutes and 5 slides (strictly regulated) about topics of controversy. Please register with the discussion leaders. |
| Moderators: Bob Hancock and Bob Lehrer. |
| 9:00-10:00 | Hour 1. The Mode of Action of Antimicrobial Peptides: membranes or something else.
Discussion leaders: Yechiel Shai and Sun Kim |
| 10:00-10:30 | Coffee |
| 10:30-11:30 | Hour 2. What are the key activities of peptides in innate immunity? i.e. Direct antimicrobial activities or effects on host processes.
Discussion Leaders: Chuck Bevins and Tom Ganz |
| 11:30-12:30 | Hour 3. Open Session.
Discussion Leaders: Birgitta Agerberth and Mike Selsted |
| Thursday PM March 22 |
| 1:30-4:00 PM | Free of all formal activity |
| 4:30-6:00 PM | Poster Session B (Cont'd) |
| 6:00-7:00 PM | Dinner |
| Practical Uses For Antimicrobial Peptides |
| Discussion Leaders: Alex Tossi and Mike Zasloff |
| 7:30-7:50 | Mike Zasloff (Magainin): Perspectives in the therapeutic uses of peptides |
| 8:00-8:20 | Ian Cottingham (PPL Therapeutics). Large scale production of antimicrobial peptides in milk of transgenic animals. |
| 8:30-8:50 | Tim Falla Mechanism of action of IB-367, a protegrin peptide in clinical development (Intrabiotics) |
| 9:00-9:20 | Patricia McNicol (Micrologix) The development of antimicrobial peptide drugs. |
| 9:20-9:35 | Santosh Misra Cationic Peptides in Transgenic Plants |
| 9:40-10:00 | Selected Poster "Short Talks" / Session Discussion |
| Friday AM March 23 |
| 7:30-8:30 AM | Breakfast |
| 9:00AM- | Departure |
