SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | 'Death: the beginning?' - Perspectives on the meaning of cell death and the importance of clearance |
| Discussion Leader: John Savill (University of Edinburgh, UK) |
7:40 pm - 8:20 pm | Andrew Wyllie (University of Cambridge, UK) "40 years of Apoptosis" |
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Peter Henson (National Jewish Health, Denver, CO) "Phagocytosis of Dying Cells: Redundant Mechanisms for Removal" |
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Hunting and Gathering: Recruitment and Recognition of Cell Death I |
| Discussion Leader: Matthew Albert (Institut Pasteur) |
9:00 am - 9:30 am | Nathalie Franc (Scripps Research Institute, La Jolla) "Calcium Homeostasis in Apoptotic Cell Clearance" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Michael Hurwitz (Yale University School of Medicine) "sli-1 Cbl Inhibits the Engulfment of Apoptotic Cells" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:45 am | Estee Kurant (Technion) "Structure-function analysis of phagocytic receptor six-microns-under (SIMU)" |
10:45 am - 10:50 am | Discussion |
10:50 am - 11:05 am | Zeng Zhou (Baylor College) "Regulation and function of the lipid second messenger PtdIns(3)P during the clearance of apoptotic cells" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Yi Chun Wu (National Taiwan University) "C. elegans integrins in engulfment" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Will Wood (University of Bath) "Detecting death or damage; Signal prioritization in Drosophila macrophages" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Hunting and Gathering: Recruitment and Recognition of Cell Death II |
| Discussion Leader: Nathalie Franc (Scripps Research Institute, La Jolla) |
7:30 pm - 8:00 pm | Douglas Green (St Jude Children's Research Hospital) Autophagy and corpse clearance |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | Short Talk: Late Breaking Abstract or Selected Talk from GRS |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:45 pm | Short Talk: Late Breaking Abstract or Selected Talk from GRS |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Ira Tabas (Columbia University) "Efferocytosis in Atherosclerosis" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Death at the Border: Recognition of cell death in the intestine and mucosal immunity |
| Discussion Leader: Peter Ernst (University of California, San Diego) |
9:00 am - 9:30 am | Julie Magarian Blander (Mt Sinai School of Medicine, New York) "Innate Immune Sensing of Cell Death and Th17 cells" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Helena Païdassi (Mass General Hospital/ University of Edinburgh) "CD103+ intestinal DCs are specialized in licensing Treg to self-associated antigens through αv integrins" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break / Group Photo |
10:30 am - 10:45 am | Brigitta Brinkmann (University of Ghent) "The role of apoptosis and necroptosis in acute DSS-induced colitis" |
10:45 am - 10:50 am | Discussion |
10:50 am - 11:05 am | Jeff Curtis (University of Michigan) "Modulation of efferocytosis by human alveolar macrophages" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Claudia Jakubzick (National Jewish Health, Denver) "Apoptotic cell acquisition by pulmonary dendritic cells" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Peter Ernst (University of California, San Diego) "Recognition of Helicobacter-induced cell death" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Cancer and Clearance: Recognition and Response to Transformed Cells |
| Discussion Leader: David Ucker (University of Illinois) |
7:30 pm - 8:00 pm | Gines Morata (Universidad Autonoma de Madrid) "Cell competition: a mechanism that recognizes and eliminates transformed cells in Drosophila" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Bernhard Brune (Goethe University, Frankfurt) "Sphingosine 1 phosphate from apoptotic cells reprograms macrophages" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Masato Tanaka (RIKEN Research Center for Allergy and Immunology) "Regulation of anti-tumor immunity by clearance of dead tumor cells" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Death, Disease and Defense: Pathological and Protective Influence of Clearance |
| Discussion Leader: Dror Mevorach (Hadassah-Hebrew University, Jerusalem) |
9:00 am - 9:30 am | Shigekazu Nagata (Kyoto University) "Exposure of phosphatidylserine to the cell surface" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Mohini Gray (University of Edinburgh) "An immunosuppressive role for TLR9 is revealed by B cell interaction with apoptotic cells" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:00 am | Keith Elkon (University of Washington) "Differential processing of Apoptotic Debris and Implications for Adaptive Immunity" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Matthew Albert (Institut Pasteur) "Dying cells actively participate in the cross-presentation of antigen" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Patrizia Rovere-Querini (Scientific Institute H S Raffaele) "Environmental cues determine the outcome of dead cell clearance in injured skeletal muscle." |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Conservation of Clearance: Recognition Mechanisms in non-death settings |
| Discussion Leader: Douglas Green (St Jude Children's Research Hospital) |
7:30 pm - 8:00 pm | Eric Baehrecke (University of Massachusetts Medical School) "The function of engulfment factors in autophagy during cell death" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Jason Mercer (Institute of Biochemistry, ETH, Zurich) "PS and the Cell Biology of Poxvirus Entry" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Mike Overholtzer (Memorial Sloan-Kettering Cancer Center) "Entosis, phagocytosis, and autophagy" |
9:20 pm - 9:30 pm | Discussion |
| |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | The Healing Hand of Death? |
| Discussion Leader: Martin Herrmann (University of Erlangen) |
9:00 am - 9:30 am | Dror Mevorach (Hadassah-Hebrew University, Jerusalem) "Apoptotic cell therapy in mice and Humans: New indications and novel mechanisms" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:00 am | Luciani Dini (University of Salento) "Phagocytosis of apoptotic and autophagic HeLa cells initiated by photodynamic therapy" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 10:55 am | Tamasin Doig (University of Edinburgh) "Transcriptional profiling of macrophages in tumours with prominent apoptosis" |
10:55 am - 11:05 am | Discussion |
11:05 am - 11:35 am | Adriano Rossi (University of Edinburgh) "Modulation of Cell Death in Inflammation" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Adrian Morelli (Thomas E Starzl Transplantation Institute, University of Pittsburgh) "Exosomes and Apoptosis Regulate Rejection" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Danger and Damage Limitation: Saving the best for last… |
| Discussion Leader: Patrizia Rovere-Querini (Scientific Institute H S Raffaele) |
7:30 pm - 8:00 pm | Angelo Manfredi (Vita Salute San Raffaele University) "HMGB1: an ancient signal of necrosis and inflammation, a player in apoptosis and NETosis" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Kodi Ravichandran (University of Virginia) "How much to eat: the phagocyte dilemma" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Martin Herrmann (University of Erlangen) "Clearance deficiency as a causative event in the etiology and pathogenesis of SLE" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |