Saturday |
2:00 pm - 5:00 pm | Arrival and Check-in |
3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
3:45 pm - 4:30 pm | Keynote Session: Death and Beyond – Resolution, Repair and Pathology |
| Discussion Leaders: Kirsten Lauber (Ludwig Maximilians University, Germany) and Sanja Arandjelovic (University of Virginia, USA) |
3:45 pm - 4:15 pm | Christopher Gregory (University of Edinburgh, United Kingdom) "Microenvironmental Conditioning by Apoptosis in Health and Disease" |
4:15 pm - 4:30 pm | Discussion |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | The Memoirs of a Corpse – A Story of Immunopathological Consequences |
| Discussion Leader: Edward Thorp (Northwestern University, USA) |
7:30 pm - 7:50 pm | Dmitri Krysko (Ghent University, Belgium) "Targeting Necroptosis Is a Novel Approach for Cancer Therapy" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Ines Santarino (CEDOC Chronic Diseases, FCM NOVA, Portugal) "p62/SQSTM1 Is Selectively Required for Phagosomal Maturation of Apoptotic Cells" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:45 pm | Amitava Das (The Ohio State University, USA) "Engulfment of Apoptotic Cells Induces Microrna-21 Expression and Switches Human Macrophages from a Pro-Inflammatory to Anti-Inflammatory Phenotype" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Gerben Marsman (Sanquin Research, The Netherlands) "Factor VII-Activating Protease Is a Regulator of Histone Cytotoxicity" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Megan Michalski (University of Michigan School of Dentistry, USA) "Macrophage Efferocytosis in the Bone Microenvironment" |
9:25 pm - 9:30 pm | Discussion |
Sunday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 11:00 am | Recognition and Engulfment of Effete Cells - What You Eat and How You
Eat Matters! |
| Discussion Leader: Kodi S. Ravichandran (University of Virginia, USA) |
9:00 am - 9:20 am | Sanja Arandjelovic (University of Virginia, USA) "Engulfment Protein ELMO1 Regulates Disease Severity in Rheumatoid Arthritis" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Shirley Dehn (Northwestern University, USA) "Hypoxia Inducible Factor-2alpha Tempers Efferocytosis, Macrophage Activation State, and Inflammation Through Mitochondrial ROS-Dependent Transcriptional Regulation of Scavenger Receptor MARCO" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:15 am | Jan Brauner (University of Erlangen-Nuremberg, Germany) "Sialylation of Anti-Histone IgG Autoantibodies Determines Their Capabilities to Participate in the Clearance of Late Apoptotic Cells" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:35 am | Jorine Willems (University of Edinburgh, United Kingdom) "Apoptosis-Driven Activation of Macrophages by Starry-Sky B-Cell Lymphoma" |
10:35 am - 10:40 am | Discussion |
10:40 am - 10:55 am | Tracy Meehan (Boston University, USA) "Analysis of Engulfment and Cell Corpse Processing by Epithelial Cells in the Drosophila Ovary" |
10:55 am - 11:00 am | Discussion |
11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
12:30 pm | Lunch |
1:30 pm - 2:30 pm | Apoptotic Mimicry and Exploitation in Pathogenesis |
| Discussion Leader: Kirsten Lauber (Ludwig Maximilians University, Germany) |
1:30 pm - 1:45 pm | Jon Etchegaray (Boston University, USA) "Defects in Phagocytic Corpse Processing Result in Neurodegeneration and Can Be Rescued by TORC1 Mediated Inhibition of Autophagy" |
1:45 pm - 1:50 pm | Discussion |
1:50 pm - 2:05 pm | Christopher Jondle (University of North Dakota, USA) "Impact of Klebsiella pneumoniae on Efferocytosis of Neutrophils" |
2:05 pm - 2:10 pm | Discussion |
2:10 pm - 2:25 pm | Jay Radke (Edward Hines, Jr., Veterans Administration Hospital, USA) "Decreased Expression of Adenoviral E1B 20K During Ad14p1 Infection Causes Increased Viral Immunopathogenesis" |
2:25 pm - 2:30 pm | Discussion |
2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
3:00 pm | Seminar Concludes |