Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Diabetes and Dyslipidemia in Atherosclerosis
Discussion Leader: Klaus Ley (La Jolla Institute for Immunology, USA)
7:40 pm - 8:05 pm
Joseph Witztum (University of California, San Diego, USA)
"Pivotal Role of Oxidized Phospholipids in NASH and Atherosclerosis"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Sudha Biddinger (Boston Children's Hospital, USA)
"Novel Mediators of Diabetes-Associated Atherosclerosis"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Karin Bornfeldt (University of Washington, USA)
"Diabetes and ApoC-III in Cardiovascular Disease"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Mary Sorci-Thomas (Medical College of Wisconsin, USA)
"Lipodystrophy and the Role of SR-BI and PCPE2"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Ira Goldberg (NYU Langone Medical Center, USA)
"Triglyceride, Lipolysis and Vascular Disease"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Atlas of the Vascular and Immune Cell Repertoire in Health and Disease
Discussion Leader: Michelle Olive (National Heart, Lung, and Blood Institute, NIH, USA)
9:00 am - 9:20 am
Klaus Ley (La Jolla Institute for Immunology, USA)
"Apolipoprotein B-Specific CD4 T Cells in Mouse and Human Atherosclerosis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Masanori Aikawa (Brigham and Women's Hospital / Harvard Medical School, USA)
"Exploring Regulators of Macrophage Heterogeneity"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Casey Romanoski (University of Arizona, USA)
"Systems Genetics of Endothelial Cell Activation"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Michael Simons (Yale University School of Medicine, USA)
"Cell Populations and Disease Progression"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Alexander Pinto (Baker Heart and Diabetes Institute, Australia)
"Novel Cellular Drivers of Tissue Fibrosis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Mete Civelek (University of Virginia, USA)
"Genetic Regulation of Human Vascular Smooth Muscle Cell Phenotypes"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Judith Sluimer (Maastricht University Medical Centre, The Netherlands)
"Single Cell Sequencing of Adventitial Mesenchymal Cells from Healthy Mice Reveals Five Differentiation Tracks from a Common Progenitor Cluster and 6 MC-Specific Genes"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Ada Weinstock (New York University School of Medicine, USA) and Kathryn Moore (New York University Medical Center, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Non-Coding RNAs in Cardiovascular Disease
Discussion Leader: Kathryn Moore (New York University Medical Center, USA)
7:30 pm - 7:45 pm
Jason Fish (University Health Network, Canada)
"Decoding the Non-Coding Regulatory Pathways of Vascular Inflammation"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Lars Maegdefessel (Technical University of Munich, Germany)
"Non-Coding RNA Regulation of Plaque (De)stabilization"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Yajaira Suarez (Yale University School of Medicine, USA)
"MicroRNA Regulation of Atherosclerosis"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Joseph Miano (University of Rochester, USA)
"LncRNAs in Vascular Pathobiology"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Zhen Chen (City of Hope, USA)
"Enhancer-Associated LncRNA in Endothelial Homeostasis"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
Elizabeth Tarling (University of California, Los Angeles, USA)
"MicroRNA Therapies to Reduce Atherosclerosis"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Macrophage Death and Resolution of Inflammation in Atherosclerosis
Discussion Leader: Edward Fisher (New York University School of Medicine, USA)
9:00 am - 9:20 am
Nick Leeper (Stanford University, USA)
"Smooth Muscle Cell Efferocytosis in Atherosclerosis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Katey Rayner (University of Ottawa Heart Institute, Canada)
"Necrotic Death in the Vessel Wall: Things Aren't Always as They Seem"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Ira Tabas (Columbia University Irving Medical Center, USA)
"Amino Acid Metabolism in Macrophages in Efferocytosis"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Edward Thorp (Northwestern University, USA)
"Immunometabolic Resolution of MI by Macrophages"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Laurent Yvan-Charvet (INSERM, France)
"Metabolic Rewiring of Macrophages in Atherosclerosis: A Sweet Balance Between Life and Death"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Trevor Fidler (Columbia University, USA)
"Increased Inflammasome Activation in Jak2v617f-Mediated Clonal Hematopoiesis Leads to Increased Macrophage Proliferation and Pyroptosis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Alberto Canfran-Duque (Yale University, USA)
"Macrophage-Derived 25-Hydroxycholesterol Orchestrates Vascular Inflammation and Plaque Remodeling in Atherosclerosis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Interface of Immune and Metabolic Responses in Atherosclerosis
Discussion Leader: Katey Rayner (University of Ottawa Heart Institute, Canada)
7:30 pm - 7:50 pm
Christopher Glass (University of California, San Diego, USA)
"Revisiting LXRs as Therapeutic Targets in Cardiovascular and Metabolic Disease"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Marit Westerterp (University Medical Center Groningen, The Netherlands)
"Cholesterol Efflux Pathways, Leukocytes and Atherosclerosis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Matthias Nahrendorf (Massachusetts General Hospital, USA)
"Myeloid Cells in Cardiovascular Health"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Robert Raffai (University of California, San Francisco / San Francisco VA Medical Center, USA)
"Macrophage Exosomes in the Pathogenesis of Diabetic Atherosclerosis"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Ada Weinstock (New York University School of Medicine, USA)
"Caloric Restriction Promotes Atherosclerosis Resolution Independent of Plasma Cholesterol and Induces Enrichment of Phagocytic Macrophages in the Adipose Tissue"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Endothelial Mechanotransduction, Metabolism and Lipoprotein Transport in Atherosclerosis
Discussion Leader: Yajaira Suarez (Yale University School of Medicine, USA)
9:00 am - 9:20 am
Myron Cybulsky (University Health Network, Canada)
"Endothelial Cell Regulation of Arterial Intimal Myeloid Cells"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Michael Potente (Max Planck Institute for Heart and Lung Research, Germany)
"Metabolic Regulation of Endothelial Cell Phenotypes"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
William Sessa (Yale University School of Medicine, USA)
"Interface of Lipid Metabolism and Inflammation in the Vessel Wall"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Princess Imoukhuede (Washington University in St. Louis, USA)
"Exploring Non-Canonical and Canonical VEGFR Signaling"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Luisa Iruela-Arispe (University of California, Los Angeles, USA)
"Endothelial-Macrophage Interactions and Atherosclerosis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Aloke Finn (CVPath Institute, USA)
"The Role of CD163 Macrophages in Vascular Calcification"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Smooth Muscle Cell Reprogramming and Clonality in Vascular Disease
Discussion Leader: William Sessa (Yale University School of Medicine, USA)
7:30 pm - 7:50 pm
Elena Aikawa (Brigham and Women's Hospital / Harvard Medical School, USA)
"Extracellular Vesicles as a Precursor of Microcalcification in Rupture-Prone Atherosclerotic Lesions"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Martin Bennett (University of Cambridge, United Kingdom)
"Control of Smooth Muscle Cell Accumulation in Atherosclerosis Through Proliferation, Death and Cell Senescence"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Daniel Greif (Yale University School of Medicine, USA)
"SMC Clonal Expansion: A Common Theme in Vascular Pathologies"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Gary Owens (University of Virginia School of Medicine, USA)
"Bioenergetic Changes Underlie PDGFBR-Driven Atherosclerotic Lesion Stabilization by Vascular Cells"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Innate and Adaptive Immunity in Atherosclerosis
Discussion Leader: Holger Winkels (La Jolla Institute for Allergy and Immunology, USA)
9:00 am - 9:20 am
Elena Galkina (Eastern Virginia Medical School, USA)
"B Cells in Atherosclerosis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Coleen McNamara (University of Virginia, USA)
"B-1b Cells Bridge Innate and Adaptive Protective Immunity in Atherosclerosis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Sabine Steffens (Ludwig Maximilian University of Munich, Germany)
"Immune Cell Lipid Signaling in Atherosclerosis and Post-Ischemic Cardiac Healing"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Ziad Mallat (University of Cambridge, United Kingdom)
"New Pathways that Control ILC2 Atheroprotective Functions"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Christian Weber (Ludwig Maximilian University of Munich, Germany)
"Novel Strategies for Immunotherapy and Vascular Protection in Atherosclerosis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Ekaterina Koltsova (Fox Chase Cancer Center, USA)
"An IL23-IL22 Axis Regulates Intestinal Microbial Homeostasis to Protect from Diet Induced Atherosclerosis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Monika Sharma (NYU Langone Health, USA)
"Role of Regulatory T Cells in Atherosclerosis Regression"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Novel Therapeutic Approaches and Diagnostic Tools for Atherosclerosis
Discussion Leader: Mary Sorci-Thomas (Medical College of Wisconsin, USA)
5:30 pm - 5:45 pm
Zahi Fayad (Icahn School of Medicine at Mount Sinai, USA)
"Cardioimmuno-Imaging and Cardioimmuno-Therapy"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:05 pm
Murray Huff (University of Western Ontario, Canada)
"ATP-Citrate Lyase as a Target for Dyslipidemia and Atherosclerosis"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
Calum MacRae (Harvard Medical School / Brigham and Women's Hospital, USA)
"New Phenotypes for Stratification and Modeling of Atherosclerosis"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
Kiran Musunuru (University of Pennsylvania, USA)
"Gene Editing to Prevent and Cure Metabolic Disorders"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Sotirios Tsimikas (University of California, San Diego, USA)
"RNA Antisense Therapeutics for Cardiovascular Diseases"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Steven Farber (Carnegie Institution for Science, USA)
"Fishing for Regulators: Live Imaging of Intestinal Lipid Flux Through Lipoprotein and Lipid Droplets Using Zebrafish"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
