Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Organelle Trafficking
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:10 pm
"Regulation of Autophagy by the Trafficking Machinery"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Insights into the Mechanism of Autophagosome Biogenesis from Yeast"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
"Coincident Detection of PI3P-RAB11A by WIPI2 Enables Autophagosome Formation on RAB11A-Positive Compartment"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lysosomes: The Final Destination
9:00 am - 9:20 am
"Lysosomes and Endolysosomes: The Dynamics of the Late Endocytic Pathway"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"The Lysosome Cargo Response"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Regulation of Endosomal Microautophagy in Drosophila "
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"LC3 Phosphorylation Is Critical for Directional Transport of Autophagic Vesicles"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Signalling Networks Controlling AMPK Activation and Autophagy"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Role of the Autophagic Protein, STX17, in Melanogenesis and Alopecia Areata"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"Cross-Talk Between mTORC1 and TFEB Regulates the Adaptive Response to Nutrient Availability and Promotes Cancer Growth"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Basic Biology of Autophagy
6:00 pm - 6:20 pm
"Novel Roles of Autophagy in Vertebrate Development"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Autophagy Contributes to Somatic Cell State Reprogramming in Plants"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"New Insights into Autophagic Regulation and Anti-Disease Function"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:30 pm
"How Rubicon Allosterically Inhibits Membrane Docking by the Autophagic PI 3-Kinase Complex"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:45 pm
"COPI Complex Depletion: ROS, Lipid Droplets and Autophagy"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Basic Mechanisms of Autophagosome Formation
9:00 am - 9:20 am
"Regulation of Autophagosome Formation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Molecular Regulation of Autophagy: Atg1/ULK1 and Friends"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Eukaryotic Translation Initiation Factor 5A Mediates Translational Control of Autophagy via ATG3"
10:10 am - 10:15 am
Discussion
10:15 am - 10:35 am
"The Molecular Mechanism Underlying Establishment and Maintenance of the ER/Isolation Membrane Contact"
10:35 am - 10:45 am
Discussion
10:45 am - 11:15 am
Coffee Break
11:15 am - 11:35 am
"Role of Lipid Synthesis in Autophagosome Biogenesis"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Acyl-CoA Synthetases Activate Fatty Acids on Forming Autophagosomes to Drive Autophagy"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Lipid Metabolism in the Regulation of Autophagy and Ageing in Yeast"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Influenza A Infection Triggers a Cellular Response that Resembles Autophagy but Has a Distinct Molecular Basis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:20 pm
"Selective Autophagy and ER Remodelling"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Targeting the Membranous Shelters of Pathogens via Autophagy Proteins"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Regulation of Selective Autophagy by Lipid-Binding Proteins"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Regulation of Nix-Mediated Mitophagy by Dimerization and Phosphorylation"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"How Cells Deploy Autophagy to Defend Against Invading Bacteria"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Inflammation and Immunity
9:00 am - 9:20 am
"Role of ATG Genes in Regulating Inflammation and Immunity"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"The WD40 Domain of ATG16L1 Supports Non-Canonical Autophagy and Dendritic Cell Antigen Presentation"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Kenny Mediates Selective Autophagic Degradation of the IKK Complex to Control Innate Immune Responses"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Translational Control of Autophagy Rejuvenates Immune Responses via eIF5A and TFEB"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"How Innate Immune Functions of Autophagy Teach Us About Its Fundamental Mechanisms"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Autophagy, Microbial Sensors and Mucosal Immunity"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Atg14 Protects the Intestinal Epithelium from TNF-Induced Apoptosis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Defining an LC3-Dependent Functional Circuit that Specifies Exosome Loading and Secretion"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:20 pm
"Intrinsic and Extrinsic Roles of Autophagy in Tumors"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Phenotypic Screening Paradigms for Autophagy Pathway Regulators"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
"Development of New PLGA Nanoemulsion Formulation to Restore Lysosomal Dysfunction in Parkinson's Disease"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Malfunctioning of Chaperone-Mediated Autophagy in Aging and Age-Related Diseases"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
General Discussion: Target Autophagy to Improve Healthspan
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Lysosomal pH Regulation: Emerging Roles in Neurodegenerative Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Mitophagy as a Regulator of Metabolism and Cell Differentiation"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Defective Axonal Autophagosome Maturation in AP-4 Deficiency Syndrome"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Understanding the Potential Role for Dysregulation of Autophagy Complexes, ULK1 and PI3KC3, in Predisposing Pathogenesis of Alzheimer's Disease"
10:10 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Autophagy and Cancer-Lessons from Drosophila "
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Autophagy in Cell Death and Cancer"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Exploring the Molecular Mechanism of Hif-2a-Mediated Pexophagy and the Role of Pexophagy in Tumorigenesis"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Modulation of Collagen Trafficking by Autophagy as a Therapy for Bone Disorders"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Differential Roles of Chronic Autophagy in Insulin Production and Sensitivity"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:20 pm
"Mitochondrial Turnover and Neuronal Homeostasis During Ageing"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
"Non-Canonical Role of Autophagy in Neurotrophin Signaling and Axonal Homeostasis"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
"The Autophagy Receptor SQSTM1/p62 Promotes Longevity in C. elegans "
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
"RFLP is an mTOR Regulated Dynein Motor Adaptor Protein Required for Mammalian Autophagosome Assembly and Transport"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
General Discussion
7:50 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure