Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Autophagy in Immunity and Neurodegenerative Diseases
Session in memory of Beth Levine
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:20 pm
"Autophagy and Atg8-ylation as a Membrane Stress Response"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Autophagy and Metabolism in the Hematopoietic System"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Nutrient Regulation of Autophagy"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Basic Autophagy Mechanisms and Regulation
9:00 am - 9:20 am
"Dynamic Membrane Binding of LC3/GABARAP Regulates Lipidation Reaction Efficiency"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Biogenesis of Non-Selective Autophagosomes"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Bridging Membrane, Cargo and Initiation: How ULK1 Does It All"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Group Photo / Coffee Break
10:50 am - 11:10 am
"Homeostatic Mitophagy Scales Mitochondrial Networks"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
"Lysosomal Signaling In Metabolic Adaptation And Cancer"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Inhibition of Early-acting Autophagy Genes in C. elegans Neurons Extends Lifespan and Improves Proteostasis via ATG-16.2 WD40 Domain"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Chaperone-Mediated Autophagy: a Gatekeeper of Neuronal Proteostasis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Molecular and Structural Mechanisms of Autophagy
7:30 pm - 7:50 pm
"Structural Regulatory Mechanisms of Autophagy and Lysosomes"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Structural Insights Into Phagophore Expansion"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"Cross-talk Between Ubiquitin and Autophagy in Cancer Stem Cells"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:10 pm
"Endoplasmic Reticulum Tubules Limit The Size of Misfolded Protein Condensates"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Selective Autophagy Mechanisms
9:00 am - 9:20 am
"Endoplasmic Reticulum Remodelling via ER-Phagy Pathways"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Novel Insights Into the Clearance of Organelles"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Lipid Droplets Modulate the Selective Autophagy Receptor SQST-1/SQSTM1 Dynamics and Aging"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"ER-Phagy Controls the Transition from Endoplasmic to Sarcoplasmic Reticulum During Myogenesis"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
"TNIP1 (Abin1) Negatively Regulates The Rate Of Mitophagy Via Interactions With FIP200 And TAX1BP1"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Regulation of Basal and Stress-Induced Mitophagy in Zebrafish"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Membrane Curvature Sensing by the Autophagy Initiation Machinery"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Autophagy in Disease: Aging and Neurodegenerative Disorders
7:30 pm - 7:50 pm
"Chaperone-Mediated Autophagy And Lipids: The Fate of Fat in the Hands of Proteins"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"The Complementary Roles of Autophagy in Neurodegenerative Disease"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Autolysosome Acidification Failure In Alzheimer’s Disease: Genetics, Mechanisms, and Broad Pathogenic Consequences"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:10 pm
"An Autophagy Activator That Improves Fitness and Extends Lifespan in C. elegans"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Non-Degradative Functions of Autophagy Proteins
9:00 am - 9:20 am
"Exploring the Crosstalk Between Autophagy And Secretion and its Role in Neurodegeneration"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Canonical and Non-Canonical Functions of the ULK/Atg1 Family of Proteins"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
"UnVAILing the Mechanisms of Noncanonical Autophagy Signaling in STING-mediated Innate Immunity "
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Molecular Features of Non-Canonical Autophagy"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
"Distinct Roles of LC3 Liipidation at Single Membrane Compartments During Influenza and Coronavirus Infection"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Autophagy Cargo Receptors are Secreted Via Extracellular Vesicles and Particles in Response to Endolysosomal Inhibition"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Atg8 Licenses Adipokine Nuclear Exit"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Autophagy in Cellular Homeostasis
7:30 pm - 7:50 pm
"Age-Dependent Retinal Degeneration In the Context of Autophagy Deficiency"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
"Autophagosome Accumulation Triggers a Signaling Response That Modifies Organelle Homeostasis and Metabolism"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Mitochondrial Homeostasis Maintained in the Absence of Autophagy"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"The Selective Autophagy Receptor p62 Regulates Lysophagy in HeLa Cells and in Neurons"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Improving Bone Health via Modulation of Glycosphingolipid Metabolism and Autophagy"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lysosome Biology in Autophagy
9:00 am - 9:20 am
"Lysosomes as Regulators of Cellular Ion Homeostasis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Control Of MiT/TFE Transcription Factors By FLCN-FNIP Complex Sequestration"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Batten Disease Protein CLN3 Mediates Lysosomal Tubulation and Autophagic Lysosome Reformation"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"The Lysosome in Nutrient Sensing and Cellular Growth Control"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
"Identification of E3 Ligase Functions In Recognizing Damaged Lysosomes Cleared By Autophagy"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Non-Cell Autonomous Regulation of Neuronal Chaperone-Mediated Autophagy"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"De Novo Regeneration of Lysosomes from Damaged Membranes During Lysophagy"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Autophagy in Disease: Cancer and Immunity
7:30 pm - 7:50 pm
"Unraveling Autophagy-Mediated Adaptation to Stress in Pancreatic Cancer"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Connections Between Autophagy and Programmed Cell Death"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Lysosome Vulnerabilities in Brain Tumors"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
"Targeting Autophagy in Humans and Human Cancers"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure