Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: New Developments in Skin and Epidermal Equivalent Models
7:40 pm - 8:20 pm
"Alternatives for Primary Keratinocytes in Experimental Dermatological Research"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
"Complexification of In Vitro 3D Skin Models: Sensory Aspects and Atopic Skin"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Insights into Barrier Function from Human Epidermal Pathology
9:00 am - 9:30 am
"Eicosanoid Metabolism in FLG-Mutated Atopic Dermatitis"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Epidermal Barrier in Atopic Dermatisis: Role of PAR-2 and Tight Junctions"
10:05 am - 10:10 am
Discussion
10:10 am - 10:35 am
Group Photo / Coffee Break
10:35 am - 11:05 am
"Role of PNPLA1 in CLE and Barrier Elaboration"
11:05 am - 11:15 am
Discussion
11:15 am - 11:45 am
"Molecular Basis of the Skin Barrier Structures Revealed by Electron Microscopy in Health and Disease"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Ultra-Long Ceramides in the Skin Barrier"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
In Silico Modeling of the Barrier and Permeation Pathways
7:30 pm - 8:00 pm
"Molecular Dynamics Simulations of Stratum Corneum Lipid Mixtures: A Multiscale Perspective"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Modeling Permeation Through Skin Lipids"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Modeling Barrier Homeostaisis Regulatory Processes "
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Spontaneous and Man-Made Animal Models of the Epidermal Barrier Dysfunction
9:00 am - 9:30 am
"RIPK4, an Important Player in Skin Homeostasis"
9:30 am - 9:45 am
Discussion
9:45 am - 10:20 am
"Cellular and Metabolic Basis for the Ichthyotic Phenotype in NIPAL4 (Ichthyin)-Deficient Canines"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:35 am
"Translational Animal Models of Atopic Dermatitis for Preclinical Studies"
11:35 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"In Silico Predictive Model Provides Rational Basis for Establishing 3-D Epidermal Equivalent Systems"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Predicting, Measuring and Modeling Topical Drug Delivery
7:30 pm - 8:00 pm
"Imaging Biodistribution of Topical Drugs In Situ Using Multimodal Optical Microscopy"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Analytical and Predictive Tools for Topical Delivery: From NCE Selection to Clinical-Ready Formulation"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Tracking Solvents in the Skin Through Atomically Resolved Measurements of Molecular Mobility in Intact Stratum Corneum"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Regulation of Epidermal Barrier Constitution and Function
9:00 am - 9:30 am
"Unusual CD44 Form in Epidermal Differentiation"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Long Noncoding RNAs in Skin Homeostasis and Disease"
10:10 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:25 am
"Micro-RNA in Skin Homeostasis and Aging"
11:25 am - 11:40 am
Discussion
11:40 am - 12:15 pm
"Pigmentation and Melanin in Skin Barrier Function"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Late-Breaking Topics / Selected Poster Presentations
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:45 pm
"The Calcium Sensing Receptor Regulates Epidermal Intracellular Ca2+ Signaling and Re-Epithelialization in Aged Epidermis"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
"Estimation of In Vivo Percutaneous Permeation (Flux) and Cumulative Amount Input of Metronidazole Formulations in Minipigs' Dermis"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
"Lipid Reductions Enable Permeation of Staphylococcus aureus Bacteria Through Human Stratum Corneum"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
"The Skin Is the Mirror of the Brain, Can the Skin Be the Biomarker of Autism?"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
"Impact of Operator Variability on the Reproducibility of Tape Stripping Results"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"Integrated In Vitro Assays to Screen Potential Dermal Toxicants in the Tox21 10K Library"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"Nonlesional Atopic Dermatitis Skin Shows Alterations in Langerhans Cells in Close Proximity to Tight Junction Fragmentation"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Insights into Stratum Corneum Lipid Composition, Organization and Dynamics
9:00 am - 9:30 am
"Rab11 and Actin-Based Myosin 5b Motor Are Crucial for Lamellar Body Trafficking in the Epidermis"
9:30 am - 9:45 am
Discussion
9:45 am - 10:20 am
"Biophysical Studies of Barrier Lipids: From Complex to Simple Models"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:35 am
"Skin Barrier Ceramide Metabolism in Health and Disease"
11:35 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"Assessment of Skin Treatment with a Lamellar Body Mimicking Lipid System"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Changes in Epidermal Barrier Function in Health and Associated with Systemic Disease
5:30 pm - 6:00 pm
"Sniffing the Barrier: Probing Skin Function Through the Volatile Footprint"
6:00 pm - 6:10 pm
Discussion
6:10 pm - 6:40 pm
"Stratum Corneum Biomarkers: A Non-Invasive Tool in Clinical Practice"
6:40 pm - 6:50 pm
Discussion
6:50 pm - 7:20 pm
"Novel Pathways of Vitamin D and Lumisterol Activation and Their Role in the Epidermis Functions"
7:20 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure