Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: New Perspectives on the CNS Barriers |
| Discussion Leader: Robert Thorne (University of Wisconsin-Madison, USA) |
7:40 pm - 7:50 pm | Opening Remarks |
7:50 pm - 8:25 pm | Fiona Doetsch (University of Basel, Switzerland) "Regulation of Adult Neural Stem Cells: Life at the Interface of Two Barriers" |
8:25 pm - 8:40 pm | Discussion |
8:40 pm - 9:15 pm | Costantino Iadecola (Weill Cornell Medicine, USA) "Neurovascular Regulation and Dysfunction in Disease States" |
9:15 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Transport, Signaling, and Junctions at the CNS Barriers and Beyond |
| Discussion Leaders: Martha O'Donnell (University of California, Davis, USA) and Lester Drewes (University of Minnesota, USA) |
9:00 am - 9:20 am | Geoffrey Chang (University of California, San Diego, USA) "P-Glycoprotein: New Insights on Structure/Function" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Tetsuya Terasaki (Tohoku University, Japan) "Transporter Proteomics at the CNS Barriers" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Nathalie Strazielle (Brain-i / BIP - Lyon Neuroscience Research Center, INSERM U1028, France) "Neuroprotective Functions of the Blood-CSF Barrier in Young Animals: Enzymes and Transporters" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Erin Schuetz (St. Jude Children's Research Hospital, USA) "Species Differences in Drug Transporters at the Blood-CSF Barriers" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Sabina Hrabetova (SUNY Downstate Medical Center, USA) "Diffusive Spread of Substances Through Brain Extracellular Space: Modulatory Role of Astroglia" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Melanie-Jane Hannocks (University of Muenster, Germany) "Molecular Characterization of the Perivascular Space and Its Relationship to the CSF" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Late-Breaking Topics |
| Session in honor of the contributions of David Miller. |
| Discussion Leaders: Stefan Liebner (University of Frankfurt, Germany) and Xavier Decleves (Université Paris Descartes, France) |
7:30 pm - 7:50 pm | Chenghua Gu (Harvard Medical School, USA) "Molecular Mechanisms Governing the Formation and Function of the Blood-Brain Barrier" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Martin Lauritzen (University of Copenhagen, Denmark) "Modification of Brain Microvascular Function In Vivo by Pericytes" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Benjamin Deverman (California Institute of Technology, USA) "CREATEing AAV Vectors that Cross CNS Barriers" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Roosmarijn Vandenbroucke (VIB, Ghent University, Belgium) "CNS Barriers Science: New Work and Concepts" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:30 pm | General Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | CNS Barrier Function in Stroke, Brain Trauma, and Epilepsy |
| Discussion Leaders: Zena Vexler (University of California, San Francisco, USA) and Richard Daneman (University of California, San Diego, USA) |
9:00 am - 9:20 am | David Antonetti (University of Michigan, USA) "Retinal Ischemia Reperfusion: A Model of Blood-Retinal Barrier Loss, Neuroinflammation, and Resolution" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Gregory Bix (University of Kentucky, USA) "A Role for α5β1 Integrin in Blood-Brain Barrier Permeability in the Context of Stroke" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Richard Keep (University of Michigan, USA) "Controversies over the Pathways Underlying Early Disruption in Ischemic and Hemorrhagic Stroke" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Group Photo / Coffee Break |
11:00 am - 11:20 am | Jerome Badaut (CNRS, France) "CNS Barrier Function in Juvenile Traumatic Brain Injury" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Bjoern Bauer (University of Kentucky, USA) "Blood-Brain Barrier Function in Epilepsy" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Patricia Dickson (Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, USA) "Intrathecal Enzyme Delivery for MPS Disorders: New Insights" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | CNS Barrier Function in Neurodegenerative Disease, Brain Cancer, and Drug Abuse |
| Discussion Leaders: Elizabeth De Lange (Leiden University, The Netherlands) and Jeffrey Iliff (Oregon Health and Science University, USA) |
7:30 pm - 7:50 pm | Anika Hartz (University of Kentucky, USA) "ABCb1 News: The Transporter and the Amyloid" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Helga De Vries (VU University Medical Center, The Netherlands) "Inflammation of the CNS Barriers in Multiple Sclerosis" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Richard Egleton (Marshall University, USA) "Opioid Regulation of Brain Endothelial Cell Function" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | William Elmquist (University of Minnesota, USA) "Impact of Focal Changes in the BBB in Treating Brain Tumors: Where, When, and How?" |
9:20 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Immunology of the CNS Barriers and Related Systems |
| Discussion Leaders: Britta Engelhardt (University of Bern, Switzerland) and Lydia Sorokin (University of Muenster, Germany) |
9:00 am - 9:20 am | Aleksandra Deczkowska (Weizmann Institute of Science, Israel) "Immune Regulation at the Choroid Plexus and Implications to Brain Ageing and Alzheimer's Disease" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Roxana Carare (University of Southampton, United Kingdom) "The Perivascular Spaces and Cerebral Lymphatic Drainage Pathways" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Zsuzsanna Fabry (University of Wisconsin-Madison, USA) "Discontinuous Distribution of Immune Cell Migration in Response to CNS Autoimmunity, Infection, and Trauma" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Erlend Nagelhus (University of Oslo, Norway) "Roles of Aquaporins at the Brain-Blood Interface" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Jorge Alvarez (University of Pennsylvania, USA) "The Blood-Meningeal Barrier and Its Role During Homeostasis and Neuroinflammation" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Maria Rosito (University of Bern, Switzerland) "Investigating the Cellular and Molecular Mechanisms Mediating the Migration of Human T Cell Subsets Across the Human Brain Barriers In Vitro" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Sunit Singh (Banaras Hindu University, India) "HIV Tat Exploits Cellular microRNA to Hit the Blood-Brain Barrier" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Novel Approaches: Imaging, Model Systems, and Technology |
| Discussion Leaders: Michael Taylor (University of Wisconsin-Madison, USA) and Ethan Lippmann (Vanderbilt University, USA) |
7:30 pm - 7:50 pm | Angela Gelli (University of California, Davis, USA) "Fungi at the Gate: How Does Cryptococcus neoformans Breach the BBB?" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Maria Deli (Biological Research Centre, Hungarian Academy of Sciences, Hungary) "New Applications of Integrated Microelectronic Lab-on-a-Chip Devices in BBB Research" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Daniela Virgintino (Bari University School of Medicine, Italy) "Cell-to-Cell Communication During Cortical Vascularization" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Maarja Andaloussi Mae (Uppsala University, Sweden) "Transcriptomic and Proteomic Analysis of the Role of Pericytes at the Blood-Brain Barrier" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Brian Chow (Harvard Medical School, USA) "Gradual Suppression of Transcytosis Governs Functional Blood-Retinal Barrier Formation" |
9:25 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | CNS Drug Delivery and Distribution: New Concepts |
| Discussion Leaders: Danica Stanimirovic (National Research Council / University of Ottawa, Canada) and Eric Shusta (University of Wisconsin-Madison, USA) |
9:00 am - 9:20 am | Margareta Hammarlund-Udenaes (Uppsala University, Sweden) "CNS Drug Delivery and Distribution: Across the BBB and into the Cells" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Frederic Calon (Laval University, Canada) "To Cross or Not to Cross the BBB: The Journey of Antibodies Targeting Transferrin Receptors" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Reina Bendayan (University of Toronto, Canada) "Regulation of ABC Drug Transporters by Nuclear Receptors: New Ways of Tightening or Opening the BBB" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Joseph Nicolazzo (Monash University, Australia) "The Role of Intracellular Proteins in Facilitating Molecular Transport Across the Blood-Brain Barrier and Implications for Alzheimer's Disease" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Vijaya Gopal (Centre for Cellular and Molecular Biology, CSIR, India) "Targeted Delivery of Short Interfering RNA Across the Blood-Brain Barrier" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Dionna Williams (Johns Hopkins University, USA) "Novel Flow Cytometric Analysis of the Blood-Brain Barrier" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Debayon Paul (UConn Health, USA) "Extracellular Vesicles as Conveyors of Tight Junction Protein to Leukocytes in Neuroinflammation" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Session: Evolving Perspectives in CNS Barriers Science: Anticipating the Next Ten Years in Academic and Industrial Partnerships |
| Discussion Leaders: N. Joan Abbott (King's College London, United Kingdom) and Axel Meyer (AbbVie Deutschland GmbH & Co KG, Germany) |
7:30 pm - 8:05 pm | Rita Balice-Gordon (Sanofi, USA) "Academic/Industrial Partnerships in CNS Barriers Science: Challenges and Opportunities" |
8:05 pm - 8:20 pm | Discussion |
8:20 pm - 8:30 pm | Saileta Prabhu (Genentech, USA) "Industrial Perspective on CNS Barriers Science: Considerations for Publishing" |
8:30 pm - 8:35 pm | Discussion |
8:35 pm - 8:45 pm | Anne Christiansen (Shire, USA) "Industrial Perspective on CNS Barriers Science: Successful Collaborations" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:00 pm | Quentin Smith (Texas Tech University Health Sciences Center, USA) "Academic Perspective on CNS Barriers Science: Developing Collaborations Between Institutions and Industry" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:15 pm | General Discussion |
9:15 pm - 9:30 pm | Closing Remarks |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |