Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Barrier Regulation and Manipulation to Treat Disease
Discussion Leader: Richard Keep (University of Michigan, United States)
7:40 pm - 8:20 pm
William Elmquist (University of Minnesota, United States)
"Marker Molecules to Measure the Blood-Brain Barrier Permeability in Brain Tumor Patients"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Peter Westenskow (F. Hoffmann-La Roche Ltd., Switzerland)
"Repairing the Blood-Retinal-Barrier to Prevent Retinopathies"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genetic Diseases and Gene Therapies Targeting BBB Biology
Discussion Leader: Dritan Agalliu (Columbia University Irving Medical Center, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Ben Deverman (Broad Institute of MIT and Harvard, United States)
"Delivering Genes Across the BBB in Mice and Humans Through the Introduction of New AAV-Receptor Interactions"
9:30 am - 9:35 am
Discussion
9:35 am - 9:45 am
Joe Nicolazzo (Monash University, Australia)
"Alterations to the Blood-Brain Barrier in Amyotrophic Lateral Sclerosis: Impact on CNS Drug Delivery"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
Alexander Sorets (Vanderbilt University, United States)
"Nonviral Lipid-siRNA Conjugate Sustains Gene Silencing in Brain Barrier Cells"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
Hamza Lalami (The University of Texas at Dallas, United States)
"Stop Codon Readthrough Regulates AQP4 Assembly and Neuromyelitis Optica Autoantibody Binding"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Anne Joutel (Inserm, France)
"A New Look at an Old Question: Why Does NOTCH3 Accumulate in the CADASIL Small Vessel Disease?"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Yosuke Hashimoto (Smurfit Institute of Genetics in Trinity College Dublin, Ireland)
"CLDN5 Missense Mutations in Neurological Diseases"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Nick Todd (Brigham and Women's Hospital, United States)
"Focused Ultrasound-Mediated Disruption of the Blood-Brain Barrier for Delivery of Gene Therapies to the Brain"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Kinya Matsuo (Yamaguchi University, Japan)
"Human iPSC-Derived Blood-Brain Barrier Models for CADASIL and HTRA1-Related Small Vessel Disease"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Dionna Williams (Emory University, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
In Vitro Models and Trafficking at the BBB
Discussion Leaders: Ana Raquel Santa-Maria (Wyss Institute, Harvard University, United States) and Akihiko Urayama (University of Texas-Houston, United States)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Morten S. Nielsen (University of Aarhus, Denmark)
"Receptor Mediated Trafficking of Antibodies in Brain Endothelial Cells"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Roberto Villasenor (Roche Innovation Center Basel, Switzerland)
"Human In Vitro Models to Investigate Intracellular Transport and Develop the Next-Generation of BrainshuttleTM Molecules"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Maria Deli (HUN-REN Biological Research Centre Szeged, Hungary)
"Induction of Blood-Brain Barrier Properties in Culture Models"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Sydney Floryanzia (University of Washington, United States)
"Response of Microfluidic Astrocyte and Pericyte Co-Culture to Oxygen-Glucose Deprivation Injury and Nanoparticles"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Pei Zhuang (Brigham and Women's Hospital, United States)
"Blood-Brain Tumor Barrier Organoid Model for Therapeutic Delivery to Glioblastoma"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Drug Delivery to the CNS. In Memory of David Begley and Danica Stanimirovic
Discussion Leaders: Thomas Davis (University of Arizona, United States) and Choi-Fong Cho (Brigham and Women's Hospital, United States)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Michelle Pizzo (Denali Therapeutics, United States)
"Utilizing the Transport Vehicle to Enhance Brain Delivery and Biodistribution of Biotherapeutics"
9:35 am - 9:40 am
Discussion
9:40 am - 10:00 am
Stina Syvänen (Uppsala University, Sweden)
"Delivering Antibody Drugs Across the Blood-Brain Barrier: PET Imaging for Enhanced Translation"
10:00 am - 10:05 am
Discussion
10:05 am - 10:25 am
Allan Jensen (H. Lundbeck A/S, Denmark)
"Drug Delivery at the Blood Brain Barrier"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:20 am
Peter Searson (Johns Hopkins University, United States)
"Tissue-Engineered Disease Models of the Blood-Brain Barrier"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
James Gorman (Wyss Institute at Harvard, United States)
"A Brain Delivery Platform of Known and Novel Shuttles"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
Fiona Elwood (Janssen R&D, United States)
"Developing Drugs for CNS Disorders: Considerations for Therapies That Cross the BBB"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Emily Han (University of Pennsylvania, United States)
"Predictive High-Throughput Platform for Dual Screening of mRNA Lipid Nanoparticle Blood-Brain Barrier Transfection and Crossing"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Understudied Cell Types and Novel Barriers of the CNS
Discussion Leaders: Benjamin Gastfriend (University of California, San Diego, United States) and Carmen Ruiz de Almodovar (University of Bonn, Germany)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Daniel Saban (Duke University School of Medicine, United States)
"When Two Phagocytes Meet at the Border: Importance of Microglia. Retinal Pigment Epithelium Interactions"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Ukpong Eyo (University of Virginia, United States)
"Microglial Regulation of Vascular Structure in Health and Disease"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
Maria Lehtinen (Boston Children's Hospital, United States)
"Choroid Plexus Regulation of Cerebrospinal Fluid-Based Signaling"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
Alison Lloyd (University College London, United Kingdom)
"Structure and Regulation of the Blood Nerve Barrier"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Peter Adamson (Breye Therapeutics, Denmark)
"Danegaptide, a GAP-Junction Stabilizer in the Treatment of Diabetic Retinopathy, Which Addresses Both Vascular Permeability and Capillary Loss"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
BBB Regulation in Neurological and Neuropsychiatric Diseases
Discussion Leaders: Gerry Grant (Duke University, United States) and Paul Lockman (West Virginia University, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Caroline Menard (Université Laval, Canada)
"The Stressed Blood-Brain Barrier: From Genes to Behaviors"
9:30 am - 9:35 am
Discussion
9:35 am - 9:55 am
Alon Friedman (Dalhousie University, Canada)
"Bridging Boundaries: Understanding Blood-Brain Barrier Permeability in Health and Disease Through Animal and Human Studies"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Myriam Heiman (Massachusetts Institute of Technology, United States)
"Cerebrovascular Targeted Gene Therapy Delays Neurodegeneration in Huntington's Disease Models"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Lara Ogunshola (University of Zurich, Switzerland)
"Unraveling Pericyte Responses During Injury and Repair With a Focus on HIF-1"
11:15 am - 11:20 am
Discussion
11:20 am - 11:40 am
Jorge Alvarez (University of Pennsylvania, United States)
"Mechanisms Regulating the Neurovascular-Immune Interplay in Neuropsychiatric Disorders"
11:40 am - 11:45 am
Discussion
11:45 am - 12:00 pm
General Discussion
12:00 pm - 12:10 pm
Briana Clary (West Virginia University, United States)
"Loss of Endothelial Cell Tissue-Nonspecific Alkaline Phosphatase Alters Circulating Extracellular Vesicle Profiles in Experimental Ischemic Stroke"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Iris Garcia-Pak (University of California San Diego, United States)
"What is the Role of the Blood-Brain Barrier in Glutamate Regulation and Brain Excitation?"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Neuroinflammation and Neuroinfections in BBB Regulation
Discussion Leaders: Ayal Ben-Zvi (Hebrew University of Jerusalem, Israel) and Tae-Eun Park (Ulsan National Institute of Science and Technology (UNIST), South Korea)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Michal Toborek (University of Miami, United States)
"Occludin as a Regulatory Protein in HIV Neuroinfection"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Robyn Klein (Western University, Canada)
"Emerging RNA Viruses and Blood-Brain Barrier Dysfunction"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
Vanessa Coelho-Santos (CIBIT/ICNAS - University of Coimbra, Portugal)
"Can Microglia-Vascular Interactions Unveil Heightened Neuroinfections Susceptibility in Developing Brains?"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Nadine Vollmuth (University of Alabama, United States)
"Estrogen Signaling Contributes to Group B Streptococcal Disruption and Invasion of Brain Endothelial Cells"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
Chris Greene (Trinity College Dublin, Ireland)
"Exploring the Prolonged Impact of Sport-Related Repetitive Head Trauma on Blood-Brain Barrier Integrity"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Dynamic Flow and Novel Concepts in the CNS Barriers
Discussion Leaders: Britta Engelhardt (University of Bern, Switzerland) and Robert Thorne (Denali Therapeutics / University of Minnesota, United States)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Martin Lauritzen (University of Copenhagen, Denmark)
"Twophoton Imaging Microscopy of Neurovascular Functions"
9:35 am - 9:40 am
Discussion
9:40 am - 10:00 am
Serge Charpak (Vision Institute, Sorbonne University, France)
"Neurovascular Coupling and Brief CO2 Interrogate Distinct Vascular Regulations"
10:00 am - 10:05 am
Discussion
10:05 am - 10:25 am
Catherine Hall (University of Sussex, United Kingdom)
"Neurons or Blood Vessels as the Earliest Drivers of Neurodegeneration?"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Andy Shih (Seattle Children's Research Institute, United States)
"Optical and Chemogenetic Dissection of Brain Capillary Function In Vivo"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Florencia Kloster (Theodor Kocher Institute, Switzerland)
"An Aquaporin-4-mRuby3 Knock-in Reporter Mouse for In Vivo Imaging of the Barrier Properties of the Glia Limitans During Immunosurveillance and Neuroinflammation"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Patric Turowski (University College London, United Kingdom)
"VEGF-Independent Leakage at the Blood-Retinal Barrier"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
María Isabel Álvarez (Uniklinikum Bonn, Germany)
"Neural Stem Cells Regulate Vascular Properties in the Adult Subventricular Zone Neurogenic Niche"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Regulating the BBB to Treat Neurological Disease
Discussion Leader: Anika Hartz (University of Kentucky, United States)
7:30 pm - 8:10 pm
Benoit Vanhollebeke (Université Libre de Bruxelles, Belgium)
"Coupling Brain Vascularization to Blood-Brain Barrier Formation Through an Organotypic Angiogenic Program"
8:10 pm - 8:30 pm
Discussion
8:30 pm - 9:10 pm
Helga De Vries (VU University Medical Center, The Netherlands)
"Neuro-Immune Events at the BBB in Dementia: A Role for Bioactive Lipids?"
9:10 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure