Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Neuropathology, Neurosurgery, and Health Disparities
Discussion Leaders: Priscilla Brastianos (Massachusetts General Hospital, United States) and Patrick Wen (Dana Farber Cancer Institute, United States)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:15 pm
Charles Eberhart (Johns Hopkins University, United States)
"The Molecular Evolution of Brain Tumor Classification - Implications for Building Models"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
Nduka Amankulor (U. Penn, United States)
"Leveraging Patient Interactions to Facilitate Scientific Discovery in Glioma: The Role of The Neurosurgeon Scientist"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:25 pm
Melissa Bondy (Stanford School of Medicine, United States)
"Molecular and Genetic Epidemiology of Glioma"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Developmental Biology of the Brain and Cancer
Discussion Leaders: Martine Roussel (St. Jude Children's Research Hospital, United States) and Charles Eberhart (Johns Hopkins University, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Michael Taylor (The Hospital for Sick Children, Canada)
"Medulloblastoma is Due to Failed Differentiation of the Human Hindbrain"
9:35 am - 9:40 am
Discussion
9:40 am - 10:10 am
Mariella Filbin (Dana-Farber Cancer Institute/Boston Children's Hospital, United States)
"Developmental Pathways, Plasticity and Neural Regulation of Pediatric High-Grade Glioma"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:15 am
Peter Dirks (Hospital for Sick Children, University of Toronto, Canada)
"Injury Reprogramming of Neural Precursors at the Root of Gliomagenesis"
11:15 am - 11:20 am
Discussion
11:20 am - 11:50 am
Hongjun Song (University of Pennsylvania, United States)
"Patient-Derived Glioblastoma Organoids for Modeling Treatment Responses"
11:50 am - 11:55 am
Discussion
11:55 am - 12:25 pm
Frank Winkler (University Hospital Heidelberg, and German Cancer Research Center, Germany)
"Brain Cancer Neuroscience: From Malignant Networks to New Therapies"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Melissa Bondy (Stanford School of Medicine, United States), Vidya Gopalakrishnan (University of Texas MD Anderson Cancer Center, United States) and Anna Lasorella (University of Miami, Miller School of Medicine, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Meningioma, Brain Metastasis and Diffuse Intrinsic Pontine Glioma
Discussion Leaders: Mariella Filbin (Dana-Farber Cancer Institute/Boston Children's Hospital, United States) and Nduka Amankulor (U. Penn, United States)
7:30 pm - 8:00 pm
Priscilla Brastianos (Massachusetts General Hospital, United States)
"Novel Precision Medicine Approaches for Primary and Metastatic Brain Tumors in the Era of Genomics"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:35 pm
Benjamin Izar (Columbia Universtiy Medical Center, United States)
"Chromosomal Instability and Brain-Metastatic Organotropism"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:10 pm
Suzanne Baker (St. Jude Children's Research Hospital, United States)
"Disrupted Development in Pediatric High-Grade Glioma"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genomics and Tumor Microenvironment
Discussion Leaders: Peter Dirks (Hospital for Sick Children, University of Toronto, Canada) and Rakesh Jain (Harvard Medical School / Massachusetts General Hospital, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Mario Suva (Mass General Hospital / Harvard Medical School, United States)
"Dissecting Human Gliomas by Single-Cell Genomics"
9:35 am - 9:40 am
Discussion
9:40 am - 10:10 am
Antonio Iavarone (University of Miami Miller School of Medicine, United States)
"Next-Generation Multi-Omics Classification and Therapeutic Stratification of Glioblastoma"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:15 am
Gelareh Zadeh (University Health Network, TWH, Canada)
"Harnessing Genomic Information to Improve Outcomes for Brain Tumors"
11:15 am - 11:20 am
Discussion
11:20 am - 11:50 am
Sanjay Kumar (University of California, Berkeley, United States)
"Multi-Omic Analysis of Invasive GBM Cells in Bioengineered Platforms and Patient Biopsies Yields Targetable Metabolic Adaptations"
11:50 am - 11:55 am
Discussion
11:55 am - 12:25 pm
Candece Gladson (Cleveland Clinic, United States)
"Integrin a3ß1 Regulation of Tumor Associated Endothelial Cell Function"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanisms
Discussion Leaders: Candece Gladson (Cleveland Clinic, United States) and Suzanne Baker (St. Jude Children's Research Hospital, United States)
7:30 pm - 8:00 pm
Vidya Gopalakrishnan (University of Texas MD Anderson Cancer Center, United States)
"Pediatric Brain Tumors and Epigenetic Determinants of Immune Sensitivity"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:35 pm
Anna Lasorella (University of Miami, Miller School of Medicine, United States)
"The Role of Germ Line Cancer Predisposition Mutations in the Pathogenesis of Glioma"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:10 pm
Dolores Hambardzumyan (Icahn School of Medicine Mounts Sinai, United States)
"Myeloid Heterogeneity and Function in Glioblastoma"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Chibawanye Ene (MD Anderson Cancer Center, United States)
"Synergizing Radiation Therapy and Myeloid Targeted Therapies for Glioblastoma"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Immunotherapy
Discussion Leaders: Michael Taylor (The Hospital for Sick Children, Canada) and Vidya Gopalakrishnan (University of Texas MD Anderson Cancer Center, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Rakesh Jain (Harvard Medical School / Massachusetts General Hospital, United States)
"Overcoming Resistance to Immunotherapy in Glioblastoma: Emerging Insights and Strategies"
9:35 am - 9:40 am
Discussion
9:40 am - 10:10 am
Duane Mitchell (University of Florida College of Medicine MD, PhD, United States)
"Clinical Translation of RNA-Based Immunotherapies for Malignant Brain Tumors"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:15 am
Kai Wucherpfennig (Dana-Farber Cancer Institute, United States)
"Targeting of the Inhibitory CD161-CLEC2D Pathway for Immunotherapy of Brain Tumors"
11:15 am - 11:20 am
Discussion
11:20 am - 11:50 am
Adam Mendel Sonabend Worthalter (Northwestern University Feinberg School of Medicine, United States)
"Addressing Drug Delivery and Refining Patient Selection to Improve Outcomes for Immunotherapy for Gliomas"
11:50 am - 11:55 am
Discussion
11:55 am - 12:25 pm
Marta Alonso (University Hospital of Navarra/ CIMA, Spain)
"Oncolytic Viruses for Pediatric Brain Tumors: The Clinical Experience with Delta-24-RGD"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Virus-Mediated Therapeutics
Discussion Leaders: Adam Mendel Sonabend Worthalter (Northwestern University Feinberg School of Medicine, United States) and Dolores Hambardzumyan (Icahn School of Medicine Mounts Sinai, United States)
7:30 pm - 8:00 pm
Frederick F. Lang (University of Texas MD Anderson Cancer Center, United States)
"Delta-24-RGD Adenoviral Therapy: From Oncolysis to Immunotherapy and Delivery"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:35 pm
Nathalie Agar (Harvard Medical School / Dana-Farber Cancer Institute / Brigham and Women's Hospital, United States)
"Gene-And Viral-Based Immunotherapies for GBM; From the Lab to the Clinic and Back to the Lab"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:10 pm
Balveen Kaur (Augusta University, United States)
"Oncolytic HSV Therapy for Brain Tumors"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Preclinical Modeling, Gene-Fusion and Mechanism-Based Therapeutics
Discussion Leaders: Frank Winkler (University Hospital Heidelberg, and German Cancer Research Center, Germany) and Antonio Iavarone (University of Miami Miller School of Medicine, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Taran Gujral (Fred Hutchinson Cancer Center, United States)
"Novel Approaches for Identifying Therapies for Gene-Fusion Driven Brain Tumors"
9:35 am - 9:40 am
Discussion
9:40 am - 10:10 am
Frank Furnari (UC San Diego, United States)
"iPSC-Derived Brain Cancer Avatars: Lessons Learned and Opportunities for Therapeutic Discovery"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:15 am
Martine Roussel (St. Jude Children's Research Hospital, United States)
"Targeting the TP53 Pathway in Atypical Teratoid/Rhabdoid Tumors"
11:15 am - 11:20 am
Discussion
11:20 am - 11:50 am
Frank Szulzewsky (Fred Hutchinson Cancer Center, United States)
"Using Transgenic Mouse Models to Understand the Biology and Resistance to Therapy of Pediatric Brain Tumors"
11:50 am - 11:55 am
Discussion
11:55 am - 12:25 pm
Alea A Mills (Cold Spring Harbor Laboratory, United States)
"Epigenetic Re-Establishment of Tumor Suppression in Glioblastoma"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Clinical Trials
Discussion Leaders: Kai Wucherpfennig (Dana-Farber Cancer Institute, United States) and Frank Furnari (UC San Diego, United States)
7:30 pm - 8:00 pm
Patrick Wen (Dana Farber Cancer Institute, United States)
"Overview of Neuro-Oncology Clinical Trials and Strategies to Improve Outcomes"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:35 pm
John Boockvar (Lenox Hill Hospital, United States)
"Overcoming the BBB to Improve the Delivery of Chemotherapeutics"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:10 pm
Anindya Bagchi (Sanford Burnham Prebys Medical Discovery Institute, United States)
"Hidden Half of the MYC Driven Medulloblastoma: New Insights and Therapeutic Potential"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure