Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Neuropathology, Neurosurgery, and Health Disparities
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:15 pm
"The Molecular Evolution of Brain Tumor Classification - Implications for Building Models"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
"Leveraging Patient Interactions to Facilitate Scientific Discovery in Glioma: The Role of The Neurosurgeon Scientist"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:25 pm
"Molecular and Genetic Epidemiology of Glioma"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Developmental Biology of the Brain and Cancer
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Medulloblastoma is Due to Failed Differentiation of the Human Hindbrain"
9:35 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Developmental Pathways, Plasticity and Neural Regulation of Pediatric High-Grade Glioma"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:15 am
"Injury Reprogramming of Neural Precursors at the Root of Gliomagenesis"
11:15 am - 11:20 am
Discussion
11:20 am - 11:50 am
"Patient-Derived Glioblastoma Organoids for Modeling Treatment Responses"
11:50 am - 11:55 am
Discussion
11:55 am - 12:25 pm
"Brain Cancer Neuroscience: From Malignant Networks to New Therapies"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Meningioma, Brain Metastasis and Diffuse Intrinsic Pontine Glioma
7:30 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:20 pm
"Novel Precision Medicine Approaches for Primary and Metastatic Brain Tumors in the Era of Genomics"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:35 pm
"Complement Factor H is A Novel Ligand for the Inducible T Cell Co-Stimulator (ICOS) and Promotes Survival of Regulatory T Cells in The Glioma Microenvironment"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Transcriptional Repressor REST Controls Autophagy in Sonic Hedgehog Medulloblastoma"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
"A Surgical Window of Opportunity Study Targeting De Novo Pyrimidine Synthesis via Inhibition of Dihydroorotate Dehydrogenase (DHODH) in Patients with IDH-Mutant Glioma"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genomics and Tumor Microenvironment
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Dissecting Human Gliomas by Single-Cell Genomics"
9:35 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Next-Generation Multi-Omics Classification and Therapeutic Stratification of Glioblastoma"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:15 am
"Multi-Omic Analysis of Invasive GBM Cells in Bioengineered Platforms and Patient Biopsies Yields Targetable Metabolic Adaptations"
11:15 am - 11:20 am
Discussion
11:20 am - 11:50 am
"Integrin a3ß1 Regulation of Tumor Associated Endothelial Cell Function"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Single Cell Profile Reveals The Genetic and Epigenetic Regulation of IDH Mutant Gliomas"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 8:00 pm
"Pediatric Brain Tumors and Epigenetic Determinants of Immune Sensitivity"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:35 pm
"The Role of Germ Line Cancer Predisposition Mutations in the Pathogenesis of Glioma"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:10 pm
"Myeloid Heterogeneity and Function in Glioblastoma"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Synergizing Radiation Therapy and Myeloid Targeted Therapies for Glioblastoma"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:45 am
"Overcoming Resistance to Immunotherapy in Glioblastoma: Emerging Insights and Strategies"
9:45 am - 9:50 am
Discussion
9:50 am - 10:20 am
"Clinical Translation of RNA-Based Immunotherapies for Malignant Brain Tumors"
10:20 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Targeting of the Inhibitory CD161-CLEC2D Pathway for Immunotherapy of Brain Tumors"
11:30 am - 11:35 am
Discussion
11:35 am - 12:05 pm
"Oncolytic Viruses for Pediatric Brain Tumors: The Clinical Experience with Delta-24-RGD"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Virus-Mediated Therapeutics
7:30 pm - 8:00 pm
"Delta-24-RGD Adenoviral Therapy: From Oncolysis to Immunotherapy and Delivery"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:35 pm
"Gene-And Viral-Based Immunotherapies for GBM; From the Lab to the Clinic and Back to the Lab"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:10 pm
"Oncolytic HSV Therapy for Brain Tumors"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Deciphering the Heterogeneity of Myeloid Cells in Gliomas"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Preclinical Modeling, Gene-Fusion and Mechanism-Based Therapeutics
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Novel Approaches for Identifying Therapies for Gene-Fusion Driven Brain Tumors"
9:35 am - 9:40 am
Discussion
9:40 am - 10:10 am
"iPSC-Derived Brain Cancer Avatars: Lessons Learned and Opportunities for Therapeutic Discovery"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:15 am
"Targeting the TP53 Pathway in Atypical Teratoid/Rhabdoid Tumors"
11:15 am - 11:20 am
Discussion
11:20 am - 11:50 am
"Using Transgenic Mouse Models to Understand the Biology and Resistance to Therapy of Pediatric Brain Tumors"
11:50 am - 11:55 am
Discussion
11:55 am - 12:25 pm
"Epigenetic Re-Establishment of Tumor Suppression in Glioblastoma"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Clinical Trial Strategies
7:30 pm - 8:00 pm
"Overview of Neuro-Oncology Clinical Trials and Strategies to Improve Outcomes"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:35 pm
"Hidden Half of the MYC Driven Medulloblastoma: New Insights and Therapeutic Potential"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Hypoxia-Induced Complement Component 3 Promotes Aggressive Tumor Growth in the Glioblastoma Microenvironment"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
"Assessment of the Response to STING Agonist Treatment and Potentiation by Manganese in Glioblastoma Cells and The Tumor Microenvironment"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Investigating Geometric Regulation of GBM Perivascular Invasion With Microengineered Cell Migration Platforms"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure