Sunday
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2:00 pm - 9:00 pm |
Arrival and Check-in
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
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7:40 pm - 9:30 pm |
Keynote Session: Creating New Activities for Chemical Applications
Discussion Leader: Stefan Lutz (Codexis Inc., USA)
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7:40 pm - 7:45 pm |
Introduction by Discussion Leader
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7:45 pm - 8:20 pm |
Don Hilvert (ETH Zurich, Switzerland)
"Design and Evolution of Artificial Metalloenzymes"
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8:20 pm - 8:35 pm |
Discussion
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8:35 pm - 8:40 pm |
Introduction by Discussion Leader
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8:40 pm - 9:15 pm |
Jeffrey Moore (Merck & Co., USA)
"The Directed Evolution of Biocatalysis"
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9:15 pm - 9:30 pm |
Discussion
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Monday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Expanding the Biocatalytic Toolbox with New Enzymes and New Functions
Discussion Leader: Mélanie Hall (University of Graz, Austria)
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9:00 am - 9:30 am |
Elizabeth Sattely (Stanford University, USA)
"New Enzymes and Chemistry in Plant Natural Product Pathways"
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9:30 am - 9:45 am |
Discussion
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9:45 am - 10:15 am |
Brent Dorr (GlaxoSmithKline, USA)
"Directed Evolution of an Amide Bond-Forming Enzyme in Organic Solvent"
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10:15 am - 10:30 am |
Discussion
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10:30 am - 11:00 am |
Coffee Break
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11:00 am - 11:30 am |
Bo Li (University of North Carolina at Chapel Hill, USA)
"New Biosynthetic Enzymes from Pathogenic Pseudomonas"
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11:30 am - 11:45 am |
Discussion
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11:45 am - 12:15 pm |
John McIntosh (Merck & Co., USA)
"Biocatalytic Synthesis of Nucleoside and Nucleotide Therapeutics"
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12:15 pm - 12:30 pm |
Discussion
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12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
|
3:00 pm - 4:00 pm |
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Sabine Flitsch (University of Manchester, United Kingdom)
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4:00 pm - 6:00 pm |
Poster Session
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
Mechanistic Understanding and Innovative Development Strategies to Enable New Applications
Discussion Leader: Wilfred van der Donk (University of Illinois at Urbana-Champaign, USA)
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7:30 pm - 8:00 pm |
Steven Boxer (Stanford University, USA)
"Magnitude and Direction of Electric Fields at the Active Sites of Enzymes"
|
8:00 pm - 8:10 pm |
Discussion
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8:10 pm - 8:40 pm |
Joelle Pelletier (Universite de Montreal, Canada)
"Accelerating Discovery of Substrate Promiscuity in Cytochrome P450 BM3"
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8:40 pm - 8:50 pm |
Discussion
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8:50 pm - 9:20 pm |
Tobias Erb (Max Planck Institute for Terrestrial Microbiology, Germany)
"Drop by Drop Towards Novel CO2 Fixing-Enzymes, Artificial Networks and Synthetic Cells"
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9:20 pm - 9:30 pm |
Discussion
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Tuesday
|
7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
From Big Data to Enzyme Function via Computational and Bioinformatic Enzyme Design
Discussion Leader: Joelle Pelletier (Universite de Montreal, Canada)
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9:00 am - 9:30 am |
Rama Ranganathan (University of Chicago, USA)
"The Evolutionary Design of Proteins"
|
9:30 am - 9:45 am |
Discussion
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9:45 am - 10:15 am |
Sílvia Osuna (University of Girona, Spain)
"Conformational Regulation in Enzyme Design and Evolution"
|
10:15 am - 10:30 am |
Discussion
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10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:30 am |
Daniela Grabs (Arzeda Corporation, USA)
"Computational Enzyme Design"
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11:30 am - 11:45 am |
Discussion
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11:45 am - 12:15 pm |
Russell Lewis (Pfizer Worldwide Research and Development, USA)
"Machine Learning-Guided Enzyme Engineering for Process Chemistry"
|
12:15 pm - 12:30 pm |
Discussion
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12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
Genome Editing and Genetic Code Expansion to Create New Functions
Discussion Leader: Xue Gao (Rice University, USA)
|
7:30 pm - 8:00 pm |
Anthony Green (University of Manchester, United Kingdom)
"Design and Evolution of Enzymes with Non-Canonical Catalytic Mechanisms"
|
8:00 pm - 8:10 pm |
Discussion
|
8:10 pm - 8:40 pm |
John Glass (J. Craig Venter Institute, USA)
"Using a Minimal Bacterial Cell to Investigate the First Principles of Cellular Life"
|
8:40 pm - 8:50 pm |
Discussion
|
8:50 pm - 9:20 pm |
Chang Liu (University of California, Irvine, USA)
"Synthetic Genetic Systems for Rapid Mutation and Continuous Evolution In Vivo"
|
9:20 pm - 9:30 pm |
Discussion
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Wednesday
|
7:30 am - 8:30 am |
Breakfast
|
8:30 am - 9:00 am |
Group Photo
|
9:00 am - 12:30 pm |
Radical Biocatalysis
Discussion Leader: Caroline Paul (Delft University of Technology, The Netherlands)
|
9:00 am - 9:30 am |
Todd Hyster (Cornell University, USA)
"Radical Biocatalysis: Using Light to Reveal New Enzyme Functions"
|
9:30 am - 9:45 am |
Discussion
|
9:45 am - 10:15 am |
Amie Boal (Pennsylvania State University, USA)
"New Enzyme Scaffolds for Iron- and Oxygen-Mediated Reactivity"
|
10:15 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:30 am |
Mohammad Seyedsayamdost (Princeton University, USA)
"Discovering and Applying New Metalloenzyme-Catalyzed Transformations"
|
11:30 am - 11:45 am |
Discussion
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11:45 am - 12:15 pm |
Shelley Minteer (University of Utah, USA)
"Enzymatic Bioelectrocatalysis: From Mechanistic Studies to Bioelectronics and Electrosynthesis Applications"
|
12:15 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:00 pm - 7:30 pm |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
7:30 pm - 9:30 pm |
Artificial Metalloenzymes
Discussion Leader: Todd Hyster (Cornell University, USA)
|
7:30 pm - 8:00 pm |
Gerard Roelfes (University of Groningen, The Netherlands)
"Designer Enzymes Featuring Unnatural Catalytic Functionalities"
|
8:00 pm - 8:10 pm |
Discussion
|
8:10 pm - 8:40 pm |
Yi Lu (University of Texas at Austin, USA)
"Designing Artificial Metalloenzymes with Activities that Rival Native Enzymes"
|
8:40 pm - 8:50 pm |
Discussion
|
8:50 pm - 9:20 pm |
Thomas Ward (University of Basel, Switzerland)
"Artificial Metalloenzymes for In Vivo Catalysis: Challenges and Opportunities"
|
9:20 pm - 9:30 pm |
Discussion
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Thursday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
Natural Product Biosynthetic Enzymes
Discussion Leader: Claudia Schmidt-Dannert (University of Minnesota, USA)
|
9:00 am - 9:30 am |
Hans Renata (The Scripps Research Institute, USA)
"Combining Synthetic Chemistry and Biology for Streamlining Access to Complex Molecules"
|
9:30 am - 9:45 am |
Discussion
|
9:45 am - 10:15 am |
Sneha Srikrishnan (Ginkgo Bioworks, USA)
"Engineering Biology at Ginkgo Bioworks: Challenging the Norm"
|
10:15 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:30 am |
Xiaoguang Lei (Peking University, China)
"Harnessing the Power of Intermolecular Diels-Alderases for the Synthesis of Structurally Complex and Bioactive Molecules"
|
11:30 am - 11:45 am |
Discussion
|
11:45 am - 12:15 pm |
Wilfred van der Donk (University of Illinois at Urbana-Champaign, USA)
"Biosynthesis and Engineering of Macrocyclic Peptides"
|
12:15 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Selected Poster Presentations
Discussion Leaders: Carlos Martinez (Pfizer Inc, USA) and Sabine Flitsch (University of Manchester, United Kingdom)
|
7:30 pm - 7:45 pm |
Short Talk Selected from Poster Abstracts
|
7:45 pm - 7:55 pm |
Discussion
|
7:55 pm - 8:10 pm |
Short Talk Selected from Poster Abstracts
|
8:10 pm - 8:20 pm |
Discussion
|
8:20 pm - 8:35 pm |
Short Talk Selected from Poster Abstracts
|
8:35 pm - 8:45 pm |
Discussion
|
8:45 pm - 9:00 pm |
Short Talk Selected from Poster Abstracts
|
9:00 pm - 9:10 pm |
Discussion
|
9:10 pm - 9:25 pm |
Short Talk Selected from Poster Abstracts
|
9:25 pm - 9:30 pm |
Discussion
|
Friday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am |
Departure
|