Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
ATP Synthase in Health and Disease
Discussion Leader: Alastair Stewart (Victor Chang Cardiac Research Institute, Australia)
7:40 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:30 pm
Leonid Sazanov (Institute of Science and Technology Austria, Austria)
"ATP Synthase and Permeability Transition Pore: A Structural Investigation"
8:30 pm - 8:45 pm
Discussion
8:45 pm - 9:15 pm
Stuti Sharma (Stony Brook University, United States)
"Conformational Ensemble of Yeast ATP Synthase at Low pH Reveal Novel Intermediates and Plasticity in F1-Fo Coupling"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Structures and Functions of Supercomplex Assemblies
Discussion Leader: Werner Kühlbrandt (Max Planck Institute of Biophysics, Germany)
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:40 am
Peter Brzezinski (Stockholm University, Sweden)
"Structure and Mechanism of Respiratory Supercomplexes"
9:40 am - 9:50 am
Discussion
9:50 am - 10:10 am
James Letts (UC Davis, United States)
"A Structural Perspective on Mitochondrial Supercomplex Diversity"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Lilach Sheiner (University of Glasgow, United Kingdom)
"The Mitochondria Respiratory Complexes of Toxoplasma Gondii MI(gh)T Just Surprise You!"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Artur Osyczka (Jagiellonian University, Poland)
"High Resolution cryo-EM Structures of Cytochrome b6f Imply a One-Way Traffic of Quinones for Efficient Photosynthesis"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Outi Haapanen (University of Helsinki, Finland)
"Inner Mitochondrial Membrane Bending Induced by I-II-III2-IV2 Supercomplex"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Volker Zickermann (Goethe University Frankfurt, Germany)
"High-Resolution CryoEM Structure of the Mrp Antiporter from Bacillus Pseudofirmus"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Karlett Parra (University of New Mexico, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Diversity and Complexity of Complex I
Discussion Leader: Ulrich Brandt (Radboud University Medical Center, The Netherlands)
7:30 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:15 pm
Judy Hirst (University of Cambridge, United Kingdom)
"Interpreting CryoEM Structures of Complex I to Elucidate the Mechanism of Catalysis"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:50 pm
Janet Vonck (MPI of Biophysics, Germany)
"The Sodium Pumping NADH:Ubiquinone Oxidoreductase from Vibrio Cholerae "
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Chris Greening (Monash University, Australia)
"Trace Gas Oxidation and Long-Range Quinone Transport: New Paradigms in Bioenergetics"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Structures and Mechanisms of Complex Redox Enzymes
Discussion Leader: Manuela Pereira (Faculdade Ciências Universidade Lisboa, Portugal)
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:40 am
Bonnie Murphy (Max Planck Institute of Biophysics, Germany)
"Structural Insights into the Bioenergetics of Dissimilatory Sulfate Reduction"
9:40 am - 9:50 am
Discussion
9:50 am - 10:10 am
Maria Maldonado (University of California, Davis, United States)
"Plant-Specific Features of Respiratory Supercomplex I+III2 From Vigna Radiata"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Thorsten Friedrich (University Freiburg, Germany)
"Structure and Function of Cytochrome bd Oxidase"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
C. S. Raman (University of Maryland Baltimore, United States)
"Hardwired Bacterial Respirasomes: Form and Function"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Hannah Bridges (University of Cambridge, United Kingdom)
"Mechanism of Biguanide Drug Inhibition of Complex I"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Tiago Beites (Weill Cornell Medical College of Cornell University, United States)
"Synthetic lethality of Mycobacterium tuberculosis NADH dehydrogenases is due to impaired NADH oxidation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Disruption of Bioenergetic Networks to Combat Drug Resistance and Disease
Discussion Leader: Jamie Blaza (Department of Chemistry, University of York, United Kingdom)
7:30 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
Tom Duncan (SUNY Upstate Medical University, United States)
"The Potential of Selectively Decoupling, Dysregulating F-ATPases/ATP synthases in Pathogenic Bacteria"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Gerhard Grüber (Nanyang Technological University, Singapore)
"From a Regulatory and Structural Understanding of Variations of OXPHOS Enzymes of Drug Resistant Microorganisms to New Inhibitory Targets, Hits and Leads"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Moe Ishikawa (Kyoto University, Japan)
"Cryo-EM Structures of Na+-pumping NADH-ubiquinone Oxidoreductase from Vibrio cholerae"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Daniel Ken Inaoka (Nagasaki University, Japan)
"Expression of an Active ASCT/SCS cycle in Mycobacterium Smegmatis Confers Resistance to Bedaquiline"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Late-Breaking Topics
Discussion Leader: Michael Boersch (Friedrich Schiller University Jena, Germany)
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:40 am
Douglas Kell (University of Liverpool, United Kingdom)
"A Protet-Based Model that Explains the Chief Anomalies in Chemiosmotic Mechanisms of Energy Coupling in Oxidative and Photosynthetic Phosphorylation"
9:40 am - 9:50 am
Discussion
9:50 am - 10:10 am
Bianca Introini (Max Planck institute of Biophysics, Germany)
"NDHI - PSI Supercomplex from Spinacia Oleracea "
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Sunil Nath (Indian Institute of Technology, Delhi, India)
"Elucidating Events Within the Catalytic Black box: Insights into the Molecular Mechanism of ATP Hydrolysis by F1-ATPase from Kinetic Analysis of the Oxygen Exchange Reactions"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
James Lee (Old Dominion University, United States)
"Mitochondrial Energetics with Transmembrane-Electrostatically Localized Protons: Do We Have A Type-B Energy Process?"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Jason Yang (Rutgers New Jersey Medical School, United States)
"Bioenergetic Insults Potentiate Cellular Respiration and Facilitate Antimicrobial Drug Resistance in Escherichia coli"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Christoph von Ballmoos (University of Bern, Switzerland)
"Oxygen in disguise: Reactions with ROS in Escherichia coli"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mitochondria Function in Health and Disease, and New Strategies for Therapy
Discussion Leader: Susanne Arnold (University of Cologne, Germany)
7:30 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:15 pm
Vamsi Mootha (Harvard Medical School, United States)
"Hypoxia as a Therapy for Mitochondrial Respiratory Chain Disorders"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:50 pm
Eric Schon (Columbia University, United States)
"Mitochondria in Alzheimer Disease: It's Not What You Think"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Erika Fernandez-Vizarra (University of Padova, Italy)
"The Cooperative Assembly Model as a Framework for Understanding Mitochondrial Respiratory Chain Organization and Function in Health and Disease"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
V-type ATPases and Mitochondrial Disease
Discussion Leader: Michael Forgac (Tufts University School of Medicine, United States)
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:40 am
Patricia Kane (Upstate Medical University, State University of New York, United States)
"Assembling the V-ATPase in Aging and Disease"
9:40 am - 9:50 am
Discussion
9:50 am - 10:10 am
Rajini Rao (Johns Hopkins University, United States)
"Endosomal NHE are Dominant Leak Pathways to Counter the Proton Pump"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Stephan Wilkens (SUNY Upstate Medical University, United States)
"Yeast V-ATPase Reversible Disassembly Revisited"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Takeshi Murata (Chiba University, Japan)
"Discovery of a Novel Inhibitor for Na+ -Transporting V-ATPase Enables Suppression of VRE Colonization in Mice and Reveals High-Resolution Structure of the Na+ Transport Pathway"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Aya Suzuki (The University of Tokyo, Japan)
"Resurrection of the Ancestral ATPase"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Dhyan Chandra (Roswell Park Comprehensive Cancer Center, United States)
"Mitochondrial Unfolded Protein Response in Bioenergetics and Cancer Cell Growth"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Bioenergetics on the Single Molecule Level and Evolution of Respiratory Complexes
Discussion Leader: Wayne Frasch (Arizona State University, United States)
7:30 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:15 pm
Hiroyuki Noji (University of Tokyo, Japan)
"Redesigning of ATPase"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:50 pm
Navish Wadhwa (Arizona State University, United States)
"Fast Mechano-Adaptation in a Macromolecular Complex"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Ranjani Murali (California Institute of Technology, United States)
"Making Sense of Aerobic Respiration Through the Lens of Ecology and Evolution"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure