Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Measuring Bioenergetics in Living Mycobacteria
Discussion Leader: Morwan Osman (University of York, United Kingdom)
3:45 pm - 4:15 pm
Jamie Blaza (Department of Chemistry, University of York, United Kingdom)
"Measuring Bioenergetics in Living Mycobacteria as they Respire and Respond to Antibiotics"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Structures of Respiratory Chain Complexes and V-ATPases
Discussion Leader: Ranjani Murali (California Institute of Technology, United States)
7:30 pm - 7:45 pm
Maria Ayala (University of California, Davis, United States)
"Understanding Mitochondrial Diseases Through Structural and Functional Studies of Supercomplexes"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Jonathan Schiller (Institute for Biochemistry II, Goethe University Hospital, Frankfurt am Main, Germany, Germany)
"Structural Basis of Complex I Assembly"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Jonathan Lasham (University of Helsinki, Finland)
"Molecular Dynamics Simulations on High Resolution Cryo-EM Structures From Complex I and Mrp Antiporter"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Kassidy Knight (SUNY Upstate Medical University, United States)
"Monoclonal Nanobodies Inhibit V-ATPase Activity and Assembly"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
John Wright (University of Cambridge, United Kingdom)
"The Active/Deactive transition of Respiratory Complex I in Proteoliposomes"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Ralf Steinhilper (Max Planck Institute of Biophysics, Germany)
"Structure of the E. coli Formate Hydrogenlyase Complex: an Ancient Member of the Complex I Superfamily"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Function of Respiratory Chain Complexes and V-ATPases
Discussion Leader: Kalaivani Saravanan (SUNY Upstate Medical University, United States)
9:00 am - 9:15 am
Rowan Walters (University of York, United Kingdom)
"Non-Invasive in vivo Measurements of the Mycobacterial Electron Transport Chain"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Tiago Beites (Weill Cornell Medical College of Cornell University, United States)
"Mycobacterium Tuberculosis Universal Stress Protein TB15.3 Plays an Essential role in the Coordination of Long-Chain Fatty Acid Catabolism with Oxidative Phosphorylation"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Joshua Meisel (Mass General Hospital/Harvard Medical School, United States)
"Mechanism of Hypoxia Rescue of Complex I Mutants Revealed Through “Hypoxia-Mimetic” Genetic Suppressors"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Sharmin Aktar (SUNY Upstate Medical University, United States)
"Regulation of Human V-ATPase Function by the Interaction between V-ATPase-aNT Domain and Phosphoinositide Lipids"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Kilian Zuchan (Aix-Marseille University, France)
"Thermodynamic Landscape of the Redox-Centres in the Electron-Confurcating [FeFe]-Hydrogenase (HydABC) of Thermotoga maritima"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Hui Zhong (University of Miami, United States)
"BOLA3 and NFU1 Link Mitoribosome Iron-Sulfur Cluster Assembly to Multiple Mitochondrial Dysfunctions Syndrome"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Explaining Your Scientific Research Using Layman's Terms
Discussion Leader: Ryohei Kobayashi (Institute for Molecular Science, Japan)
1:30 pm - 1:40 pm
Aya Suzuki (The University of Tokyo, Japan)
"Resurrection of the Ancestral ATPase -Surpass “Jurassic Park”-"
1:40 pm - 1:45 pm
Discussion
1:45 pm - 1:55 pm
Dongsheng Yin (Max Planck Institute of Biophysics, Germany)
"Studying Redox Proteins with Cryogenic Electron Microscopy"
1:55 pm - 2:00 pm
Discussion
2:00 pm - 2:10 pm
Moe Ishikawa (Kyoto University, Japan)
"Cryo-EM Structures of Na+-Pumping NADH-Ubiquinone Oxidoreductase from Vibrio Cholerae"
2:10 pm - 2:15 pm
Discussion
2:15 pm - 2:25 pm
Md Murad Khan (SUNY Upstate Medical University, United States)
"Role of Oxr1p in Yeast V-ATPase Regulation"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes