| SUNDAY |
| 4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Overview: Host-Pathogen interactions in the lung |
| Discussion Leader: Joseph Mizgerd (Boston University School of Medicine) |
| 7:40 pm - 8:25 pm | Bali Pulendran (Emory Vaccine Center)
"Dendritic Cell biology in the host response to pneumonia" |
| 8:25 pm - 8:35 pm | Discussion
|
| 8:35 pm - 9:20 pm | Steven Holland (NIAID)
"Defects in innate immunity and pneumonia" |
| 9:20 pm - 9:30 pm | Discussion
|
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Epithelial cell signaling and immunity in lung infection |
| Discussion Leader: Theodore Standiford (University of Michigan) |
| 9:00 am - 9:45 am | Peter Openshaw (Imperial College London)
"How RSV causes disease" |
| 9:45 am - 10:00 am | Discussion |
| 10:00 am - 10:30 am | Group Photo / Coffee Break |
| 10:30 am - 11:00 am | Nicholas Lukacs (University of Michigan)
"Respiratory syncytial virus-induced pathogenesis and regulation of pulmonary immune responses" |
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:40 am | Steven Varga (University of Iowa)
"Regulation of the RSV-specific CD8 T cell response" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:20 pm | Jeffrey Whitsett (Cincinnati Children's Hospital)
"Regulation of innate immunity by the respiratory epithelium" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I (last names A-K) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Bacterial infections: genomics/pathogenesis/epidemiology |
| Discussion Leader: Juliane Bubeck-Wardenburg (University of Chicago) |
| 7:30 pm - 8:15 pm | Juliane Bubeck-Wardenburg (University of Chicago)
"The contribution of alpha-hemolysin to S. aureus pathogenesis" |
| 8:15 pm - 8:25 pm | Discussion |
| 8:25 pm - 8:55 pm | Binh An Diep (UCSF)
"Pathogenesis of S. aureus necrotizing pneumonia" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:25 pm | Min Li (Fudan University)
"The molecular basis of an MRSA epidemic wave in China" |
| 9:25 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Innate Immunity / Bacterial infection |
| Discussion Leader: Jane Deng (UCLA Medical Center) |
| 9:00 am - 9:30 am | Augustine Choi (Harvard Medical School)
"Crosstalk between autophagy and inflammasomes in innate immunity" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Jerry Simecka (UNT Health Science Center)
"Immunopathology of Mycoplasma Pneumonia" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:40 am | Coffee Break |
| 10:40 am - 11:10 am | Eric Harvill (Penn State University)
"Immunopathogenesis of pertussis" |
| 11:10 am - 11:15 am | Discussion |
| 11:15 am - 11:45 am | Thomas Clark (CDC)
"Pertussis: Current Epidemiology and Implications for Vaccination Programs" |
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:05 pm | Short Talk: Kenichi Shimada (Cedars-Sinai Medical Center)
"Activation of the NLRP3 Inflammasome by Oxidized Mitochondrial DNA during Apoptosis" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Short Talk: Vijay Sivaraman (University Of North Carolina)
"Characterization of Early Immune Responses During Primary Pneumonic Plague" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I (last names A-K) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Immunopathogenesis of fungal infection |
| Discussion Leader: Chad Steele (University of Alabama at Birmingham) |
| 7:30 pm - 7:55 pm | George Deepe (University of Cincinnati College of Medicine)
"Chemokine-Cytokine Nexus and Fungal Immunity in the Lung" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:25 pm | Stuart Levitz (University of Massachusetts Medical School)
"Plasmacytoid dendritic cells in fungal host defenses" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:55 pm | Tobias Hohl (Fred Hutchinson Cancer Research Center)
"Host defense against respiratory fungal infection" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:25 pm | Marcel Wuethrich (University of Wisconsin)
"The induction of vaccine-induced anti-fungal T17 cells" |
| 9:25 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Inflammasome/Autophagy/Influenza |
| Discussion Leader: Jim Crowe (Vanderbilt University Medical Center) |
| 9:00 am - 9:30 am | Alan Hauser (Northwestern University)
"An rhs gene of Pseudomonas aeruginosa enhances virulence and activates the inflammasome" |
| 9:30 am - 9:35 am | Discussion |
| 9:35 am - 10:05 am | Irving Coy Allen (University of North Carolina at Chapel Hill)
"The role of NLRs during acute respiratory infection" |
| 10:05 am - 10:15 am | Discussion |
| 10:15 am - 10:30 am | Coffee Break |
| 10:30 am - 11:00 am | Adolfo Garcia-Sastre (Mount Sinai School of Medicine)
"Induction and evasion of interferon responses by influenza viruses" |
| 11:00 am - 11:05 am | Discussion |
| 11:05 am - 11:35 am | Daniel Perez (University of Maryland)
"Is there room for the influenza 'transmisome'?" |
| 11:35 am - 11:40 am | Discussion |
| 11:40 am - 12:10 pm | Jasmine Perez (Mount Sinai School of Medicine)
"The biology of Influenza A Virus-Generated Small RNAs" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Short Talk: Sarah Vaughan (Lovelace Respiratory Research Institute)
"Attenuated Dendritic Cell Function and Lack of Protection in BALB/c Mice Following HPAI Vaccination" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II (last names L-Z) |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
| 7:30 pm - 9:30 pm | Immune cell recruitment and signaling in bacterial infection |
| Discussion Leader: Anuradha Ray (University of Pittsburgh) |
| 7:30 pm - 8:00 pm | Jay Kolls (LSU)
"Mucosal Immune requirements for prevention of infection with multi-drug resistant Klebsiella pneumoniae" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Paul Kubes (University of Calgary)
"Mechanisms of PMN recruitment" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Theodore Standiford (University of Michigan)
"Response of the lung to sepsis" |
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Vaccines and Respiratory Viruses |
| Discussion Leader: Joan Durbin (NYU Langone Medical Center) |
| 9:00 am - 9:30 am | Hana Golding (FDA)
"Expansion of antibody repertoires and affinity maturation following infection or vaccination with influenza viruses" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Ursula Buchholz (NIAID)
"Host response to pneumovirus infection" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:40 am | Coffee Break |
| 10:40 am - 11:10 am | Stephania Cormier (Louisiana State University Health Sciences Center)
"Why Timing of Initial RSV Infection is Important" |
| 11:10 am - 11:15 am | Discussion |
| 11:15 am - 11:45 am | James Crowe (Vanderbilt University Medical Center)
"Respiratory virus infection of polarized epithelial cells" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:25 pm | Paul Planet (Columbia University)
"Evolution of the USA300 genome" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II (last names L-Z) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Bacterial/Viral co-infection and the resolution of pneumonia |
| Discussion Leader: Ursula Buchholz (NIAID) |
| 7:30 pm - 7:40 pm | Thomas Kuri (Karolinska Institute, MTC)
"Influenza virus selectively enhances IL-12p70 secretion by human dendritic cells infected with Streptococcus pneumonia" |
| 7:40 pm - 7:45 pm | Discussion |
| 7:45 pm - 8:15 pm | Suzanne Dawid (University of Michigan)
"The role of bacterial competition in respiratory tract colonization by Streptococcus pneumoniae" |
| 8:15 pm - 8:25 pm | Discussion |
| 8:25 pm - 8:35 pm | Prabir Ray (University Of Pittsburgh)
"Lung Interstitial MDSC-like Cells In Resolution of Tissue Inflammation After Bacterial Pneumonia"
|
| 8:35 pm - 8:40 pm | Discussion |
| 8:45 pm - 9:15 pm | Bruce Levy (Harvard Medical School)
"Lipoxins and resolvins promote the resolution of bacterial pneumonia and ALI" |
| 9:15 pm - 9:25 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |