Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Conserved Pathways
7:40 pm - 8:20 pm
"Immune Surveillance in the Regulation of C. elegans Aging"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Sexual Dimorphic Role of Neuronal Insulin Signaling on Health Span"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"NAD Metabolism During Aging: Insight from Quantitative Flux Analysis"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Age-Onset Phosphorylation of a Minor Actin Variant Promotes Intestinal Barrier Dysfunction and Pathogenesis"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:30 am
"How to Die Young at a Very Old Age"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Targeting Aging Through mTOR Inhibition: New Insights into Mechanisms and Opportunities for Clinical Intervention"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Targetting Telomeres in Aging and Age-Related Pathologies"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Two Specific m5C-Modifications of Ribosomal RNA Modulate Healthy Lifespan and Development"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Maternal Age and Maternal Diet Affect Offspring Lifespan, Fitness and Response to Caloric Restriction"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chromatin and Epigenetics
7:30 pm - 8:00 pm
"Linking Epigenetics, Metabolism and Cancer: Lessons from SIRT6"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Single Cell Epigenome Landscape of Aging"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Activation of Endogenous Retrotransposable Elements as a Mechanism Contributing to Age-Associated Sterile Inflammation"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:30 am
"SIRT6 in Heterochromatin Silencing and Aging"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Genes and Small Molecules to Slow the Pace of Aging"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Metabolite Signals in Aging"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Examining the DNA Methylation Age Reset that Occurs During iPSC Reprogramming"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Stress Response and a P53 Duplication in the Long-Lived Bat, Myotis lucifugus "
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Methylome-Wide Analysis of Aging and Lifespan in the BXD Inbred Mouse Strains"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metabolites and Signaling
7:30 pm - 8:00 pm
"NAD World 3.0: The Inter-Tissue Interactions Mediated by eNAMPT and NMN in Mammalian Aging/Longevity Control"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Study of Longitudinal Aging in Mice and Caloric Restriction"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Tissue-Specific Manipulations of Methionine and Tyrosine Metabolism Extend Health and Lifespan in Drosophila "
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Diet-Induced Obesity Causes Metabolic Reprogramming and Suppresses Immunity in the Tumor Microenvironment"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:30 am
"Systems Analysis and Systems Intervention of Aging"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Selective Autophagy in the Remodeling of the Cellular Proteome in Aging"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Cellular Recycling: Role of Autophagy in Aging and Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Transient Non-Integrative Epigenetic Reprogramming Promotes Multifaceted Reversal of Aging in Human Cells"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"The Role of Ribosomal Composition in Selective Translation of Longevity Genes Under Dietary Restriction"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Cell Size Determines Stem Cell Potential During Aging"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
7:30 pm - 8:00 pm
"Nutrient-Sensing Mechanisms and Longevity"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Redox Regulation of Aging"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Lifestyle, Trauma and Immune Aging"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stem Cells and Clonal Dynamics
9:00 am - 9:30 am
"Clonal Stem Cells and Aging"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Epigenetic and Metabolic Regulation of Aging "
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"New Tools for Studying the Role of Energy Metabolism in Physiology and Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
" Comparative Genomics and Transcriptional Aging"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"PGC-1s Control Epidermal Physiology by Modulating Keratinocyte Proliferation and Terminal Differentiation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Keynote Session: Cellular Senescence
5:30 pm - 6:10 pm
"Aging (or Not) in C. elegans "
6:10 pm - 6:20 pm
Discussion
6:20 pm - 6:50 pm
"How Neurons Degenerate in Aging Diseases: Engaging the Neuronal Cytoskeleton in the Biogenesis of Prion Aggregates"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:15 pm
"Lyso-Phospholipids Contribute to the Pro-Inflammatory and Immunomodulatory Activity of Senescent Fibroblasts"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:30 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure