Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Environment and Stem Cell Aging
Discussion Leaders: Vera Gorbunova (University of Rochester, United States)
7:40 pm - 8:20 pm
Anne Brunet (Stanford University, United States)
"Understanding Aging and Suspended Animation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Short Talk Selected from Poster Abstracts
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Short Talk Selected from Poster Abstracts
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Microbiome Dynamics During Aging
Discussion Leaders: Bali Pulendran (Stanford University, United States)
9:00 am - 9:30 am
Michelle Linterman (Babraham Institute, United Kingdom)
"Mechanisms Underpinning Poor Vaccine Responses in Older Individuals"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Filipe Cabreiro (University of Cologne and Imperial College London, Germany)
"Microbiota Polypharmacology for Improving Ageing"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Isabel Gordo (Instituto Gulbenkian de Ciência, Portugal)
"The Tempo and Mode of Evolution of E.Coli in The Mammalian Intestine"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Short Talk Selected from Poster Abstracts
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Dushani Palliyaguru (National Institute on Aging, United States) and Samir Morsli (University of Cambridge, United Kingdom)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Immune Aging
Discussion Leader: Michelle Linterman (Babraham Institute, United Kingdom)
6:00 pm - 6:30 pm
María Mittelbrunn (Molecular Biology Center “Severo Ochoa”, CSIC, Spain)
"Immunometabolism at the Crossroad Between Inflammation and Aging"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:10 pm
Naomi Habib (Hebrew University of Jerusalem, Israel)
"Reconstructing Dynamics of Cellular Environments in Aging Brains"
7:10 pm - 7:20 pm
Discussion
7:20 pm - 7:50 pm
Andrea Ablasser (Global Health Institute, Ecole Polytechnique Federale de Lausanne, Switzerland)
"The cGAS-STING Pathway Drives Aging-Associated Inflammation and Neurodegeneration"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Comparative Biology of Aging
Discussion Leader: Isabel Gordo (Instituto Gulbenkian de Ciência, Portugal)
9:00 am - 9:30 am
Peter Sudmant (University of California Berkeley, United States)
"The Genetics of Aging at Cellular, Organismal, and Population Scales"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Kyoko Miura (Kumamoto University, Japan)
"Regulation of Cell Death and Cellular Senescence in the Long-Lived African Mole-Rats"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Alessandro Ori (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Germany)
"The Proteome of the Aging Vertebrate Brain"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Short Talk Selected from Poster Abstracts
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
New Technologies to Study Aging
Discussion Leaders: Sara Wickstrom (University of Helsinki, Finland)
6:00 pm - 6:30 pm
Xiao Wang (MIT/Broad Institute, United States)
"Translating Spatial Cell Atlas to Tissue Function and Dysfunction"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 6:55 pm
Short Talk Selected from Poster Abstracts
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:15 pm
Short Talk Selected from Poster Abstracts
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:50 pm
Alex Cagan (Wellcome Sanger Institute, United Kingdom)
"The Impossibility of Whales: Somatic Mutation Across the Tree of Life"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell Intrinsic Versus Extrinsic Aging
Discussion Leader: Richard Miller (University of Michigan, United States)
9:00 am - 9:30 am
Eva Hoffmann (University of Copenhagen, Denmark)
"Molecular Regulation of Reproductive Aging in Human Females"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Sara Wickstrom (University of Helsinki, Finland)
"Regulation of Stem Cell fate and Aging by Mechanical Forces"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Short Talk Selected from Poster Abstracts
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
Short Talk Selected from Poster Abstracts
11:45 am - 11:50 am
Discussion
11:50 am - 12:20 pm
Saul Villeda (University of California, San Francisco, United States)
"Systemic Mechanisms of Brain Aging and Rejuvenation"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Systems Biology of Aging
Discussion Leaders: Peter Sudmant (University of California Berkeley, United States)
6:00 pm - 6:30 pm
Keenan Walker (National Institute on Aging (NIA), United States)
"Peripheral Drivers of Alzheimer's Disease and Dementia Identified Using Plasma Proteomics"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 6:55 pm
Short Talk Selected from Poster Abstracts
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:15 pm
Short Talk Selected from Poster Abstracts
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:50 pm
Uri Alon (Weizmann, Israel)
"A Circuit Approach to Dissect the Complexity of Aging"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Immune Interventions, Vaccines and Aging
Discussion Leader: Andrea Ablasser (Global Health Institute, Ecole Polytechnique Federale de Lausanne, Switzerland)
9:00 am - 9:30 am
Arne Akbar (University College London, United Kingdom)
"Strategies to Enhance Immunity During Ageing"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Benoit Lehallier (Alkahest, United States)
"Molecularizing the Whispers of Aging from Blood to Target Disease"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Bali Pulendran (Stanford University, United States)
"Systems Biological Analysis of Immunity to Infection and Vaccination"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Short Talk Selected from Poster Abstracts
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Aging Mosaicism
Discussion Leaders: Jennifer Garrison (Buck Institute for Research on Aging, United States)
6:00 pm - 6:30 pm
Corina Amor (CSHL, United States)
"Harnessing senolytic CAR T cells to reverse and prevent aging phenotypes"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 6:55 pm
Short Talk Selected from Poster Abstracts
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:40 pm
Martin Hetzer (Institute of Science and Technology Austria (ISTA), Austria)
"Protein Homeostasis and Lifelong Cell Maintenance"
7:40 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure