Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Spirochete
Biology: Insights and Vistas
7:40 pm - 8:10 pm
"Divergent Adaptations by Spirochetes Transmitted by Fast and Slow Feeding Ticks: Why Relapsing Fever Spirochetes Are So Special!"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 9:00 pm
"Syphilis – What a Way to Make a Living!?!"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Long Term In Vitro Cultivation of Treponema pallidum "
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Fundamentals
of Spirochete Biology
9:00 am - 9:30 am
"The Treponema pallidum Outer Membrane: 30+ Years Trying to Figure Out What Is Out There"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Leptospira Comparative Genomics"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Outer Membrane Biogenesis Requires a Unique Protein Export System in B. burgdorferi "
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
"Two Dinucleotide Second Messengers Control Adaptation to Each Host During the Enzootic Cycle of Borrelia burgdorferi "
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"The Hook Protein of Spirochetes Is a Covalent Cross-Linking Machine"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Identification of Molecular Mechanisms of Adaptation to Osmotic Stress in Leptospira biflexa "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Bacterial-Host
Interactions: Virulence Attributes
7:30 pm - 7:50 pm
"Interactions of the Treponema pallidum Adhesin Tp0751 with the Host Vascular Endothelium"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Virulence Proteins of Pathogenic Leptospira Species"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Infection Biology of RF Borrelia – Impact of Erythrocyte Rosetting During Infection"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
"Identification of Two Ixodes scapularis Salivary Proteins Capable of Stimulating Chemotaxis in Borrelia burgdorferi "
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Ecological, Social, and Epidemiological Elements of Leptospirosis Transmission at Varying Scales"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Assessment of Mass Azithromycin Treatment for Yaws Using Epidemiological and Molecular Approaches"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"One Health: The Relationship of Simian and Human Treponemes"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Geographic Variation in the Risk of Lyme Disease in the Eastern U.S: How Ecology Matters"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Veterinary Brachyspiras: Old and New"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Leptospirosis Burden in Africa with Recent Updates from Tanzania"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Bacterial-Host
Interactions: Explorations
7:30 pm - 7:50 pm
"New Insights into the Symbiosis Between Termite Gut Spirochetes and Their Insect Hosts"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"The Role of Thermolysins in Leptospira Pathogenesis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Molecular Mechanisms of Classical Pathway Complement Evasion by Borrelia spp"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
"Transposon Insertional Sequencing as a Tool to Identify Genes Required for Borrelia burgdorferi Survival in Ticks"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Spirochetes
vs. Host Defenses and Responses
9:00 am - 9:20 am
"Escape of TLR5 Recognition by Pathogenic Leptospira : A Rationale for Endoflagella"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"The Role of the Macrophage in Spirochetal Recognition and Clearance"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Acute and Chronic Murine Response to Leptospira Infection"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Treponemes Causing Digital Dermatitis in Cattle Are Now Emerging in New Diseases on Farms and in the Wild"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Fibroblast-Derived Antigen Presenting Cells (fAPCs) Shape Autoimmunity in Post-Infectious Lyme Arthritis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Borrelia burgdorferi Peptidoglycan: Driving the Pathogenesis of Lyme Arthritis?"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
7:30 pm - 7:50 pm
"Impact of Genome Variations and Host Association on Emergence and Evolution of Lyme Disease Spirochetes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Evolutionary Biology of Peromyscus , the Natural Host for Lyme Disease Agents and Other Human Pathogens"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Genomic Approaches to Understanding the Origins of Syphilis and Its Re-Emergence"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
"The Roles of the Restriction-Modification System of Borrelia burgdorferi "
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Dissemination
and Persistence
9:00 am - 9:20 am
"Multidimensional Modeling of the Immune Response to Borrelia burgdorferi in Humans"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Determination of the Genetic Basis for Borrelia burgdorferi Mammalian Infectivity"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Regulation of Gene Expression in Treponema pallidum by Poly-G Repeats"
10:20 am - 10:30 am
Discussion
10:30 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Defining the Presentations of Lyme Disease Through Small Molecule Metabolism"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
"Mechanisms of Survival of Pathogenic Leptospira in Soil and Water"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Movement of the Outer Membrane in Leptospira : Implication for Their Diverse Motilities"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"PerR-Regulated Adaptation to Oxidative Stress in Pathogenic Leptospira : Two Is Better than One!"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Frontiers
in Spirochete Research: The Next Big Questions
7:30 pm - 8:00 pm
"Putting It All Together: Spirochetal Biology in the Post-Hypothetical Era"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"A 'Tail' of 2 Megabases: Unexpected Pathways Influenced by an Unconventional Genetic Region"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Leptospirosis Trek: Going Where No One Has Gone Before"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure