| SUNDAY |
| 7:15 - 7:30 | Welcome and Introduction |
| 7:30 pm | MACROMOLECULAR ARCHITECTURE |
| Session Chair: Milan Mrksich, U. Chicago |
| 7:30 - 8:00 | Fraser Stoddart (UCLA)
"Concept Transfer from Biology via Chemistry to Electronic Devices" |
| 8:00 - 8:10 | Discussion |
| 8:10 - 8:40 | Thomas Moore (Arizona State)
"The Design and Assembly of Artificial Photosynthetic Membranes" |
| 8:40 - 8:50 | Discussion |
| 8:50 - 9:05 | Break |
| 9:05 - 9:35 | Ned Seeman (New York University)
"DNA Nanotechnology" |
| 9:35 - 9:45 | Discussion |
| MONDAY |
| 8:30 - 9:00 | Photo session |
| 9:00 am | NEURODEGENERATIVE & INFECTIOUS DISEASES |
| Session Chair: Wilfred van der Donk, U. of Illinois |
| 9:00 - 9:30 | Jeff Kelly (Scripps)
"Developing Therapeutic Strategies for Human Amyloid Diseases" |
| 9:30 - 9:40 | Discussion |
| 9:40 - 10:10 | Peter Lansbury (Harvard Med)
"Deciphering the Role of Alpha-Synucelin Fibrillization in Parkinson's Disease" |
| 10:10 - 10:20 | Discussion |
| 10:20 - 10:35 | Break |
| 10:35 - 11:05 | Larry Blaszczak (Eli Lilly)
"Peptidoglycan Biosynthesis: Studies on the Transglycosylation Reaction" |
| 11:05 - 11:15 | Discussion |
| 11:15 - 11:45 | Jeff Jacobs (Versicor)
"Combinatorial Modification of Antibacterial Natural Products: Synthesis and in vitro Analysis of Derivatives of Thiazole Peptide GE 2270" |
| 11:45 - 11:55 | Discussion |
| 11:55 - 12:10 | Poster I |
| 12:10 - 12:25 | Poster II |
| 7:30 pm | 7-TM RECEPTORS |
| Session Chair: Albert Jaxa-Chamiec, GlaxoWellcome |
| 7:15 - 7:45 | Athan Kuliopolis (NE Med Center)
"Human Yeast Signal Transduction" |
| 7:45 - 7:55 | Discussion |
| 7:55 - 8:25 | Tracy Handel (UC Berkeley)
"Structure-Function Studies of Chemokines and Interactions with their receptors" |
| 8:25 - 8:35 | Discussion |
| 8:35 - 8:50 | Break |
| 8:50 - 9:20 | Susan Rohrer (Merck)
"Rapid Identification of Subtype- Selective Agonists of the Somatostatin Receptor Through Combinatorial Chemistry" |
| 9:20 - 9:30 | Discussion |
| TUESDAY |
| 9:00 am | ENZYME INHIBITORS/MECHANISM |
| Session Chair: Virginia Cornish, Columbia |
| 9:00 - 9:30 | Yoshi Ichikawa (Johns Hopkins)
"Inhibitors of Glycozymes" |
| 9:30 - 9:40 | Discussion |
| 9:40 - 10:10 | Martin Tanner (University of British Columbia)
"Enzymatic Eliminations Involving Non-Acidic Protons" |
| 10:10 - 10:20 | Discussion |
| 10:20 - 10:35 | Break |
| 10:35 - 11:05 | Neil Marsh (U. Michigan)
"Glutamate Mutase, Coenzyme B12 and Free Radicals" |
| 11:05 - 11:15 | Discussion |
| 11:15 - 11:45 | Vince Rotello (U. Mass)
"Model Systems for Flavoenzyme Activity, Plus a Few Surprises" |
| 11:45 -11:55 | Discussion |
| 11:55 - 12:10 | Poster III |
| 12:10 - 12:25 | Poster IV |
| 7:30 pm | NUCLEIC ACIDS |
| Session Chair: Anna Mapp, Caltech |
| 7:15 - 7:45 | Jumi Shin (Pittsburgh)
"Targeting the DNA Major Groove with Dimeric Helical Proteins" |
| 7:45 - 7:55 | Discussion |
| 7:55 - 8:25 | Ron Breaker (Yale)
"Allosteric RNA and DNA Enzymes" |
| 8:25 - 8:35 | Discussion |
| 8:35 - 8:50 | Break |
| 8:50 - 9:20 | Alanna Schepartz (Yale)
"Miniature Proteins" |
| 9:20 - 9:30 | Discussion |
| WEDNESDAY |
| 9:00 am | CHEMICAL BIOLOGY |
| Session Chair: Karlene Cimprich, Stanford University |
| 9:00 - 9:30 | John Koh (University of Delaware)
"New Transcriptional Regulators from Rationally Modified Nuclear Hormone Receptors" |
| 9:30 - 9:40 | Discussion |
| 9:40 - 10:10 | Tom Wandless (Stanford University)
"Hijacking Cellular Proteins" |
| 10:10 - 10:20 | Discussion |
| 10:20 - 10:35 | Break |
| 10:35 - 11:05 | Martha Oakley (Indiana)
"Coiled Coils, Helices, and DNA" |
| 11:05 - 11:15 | Discussion |
| 11:15 - 11:45 | Tim Mitchison (ICCB, Harvard)
"Probing the Cytoskeleton with 'Chemical Genetics'" |
| 11:45 - 11:55 | Discussion |
| 11:55 - 12:10 | Poster V |
| 12:10 - 12:25 | Poster VI |
| 7:15 pm | CHEMICAL BIOLOGY II |
| Session Chair: David Liu, Harvard University |
| 7:15 - 7:45 | Business Meeting |
| 7:45 - 8:15 | Jeff Huth (Abbott Labs)
"Utility of NMR in the Discovery of LFA-1 Antagonists" |
| 8:15 - 8:25 | Discussion |
| 8:25 - 8:55 | Bruce Armitage (Carnegie Mellon)
"Cooperative Assembly of Helical Dye Aggregates on Nucleic Acid Templates" |
| 8:55 - 9:05 | Discussion |
| 9:05 - 9:20 | Break |
| 9:20 - 9:50 | Anthony Bishop (Princeton)
"Probing Signal Transduction with Small molecules: A Chemical Genetic Switch for Target Specific Inhibitors of Any Protein Kinase" |
| 9:50 - 10:00 | Discussion |
| THURSDAY |
| 9:00 am | ION CHANNELS |
| Session Chair: Craig Beeson, University of Washington |
| 9:00 - 9:30 | Udi Isacoff (UC Berkeley)
"Optical Reporters of Cell Signaling Based on Fluorescent Proteins" |
| 9:30 - 9:40 | Discussion |
| 9:40 - 10:10 | Bruce Cohen (UCSF)
"Probing Channel Dynamics with a Unique Intrinsic Fluorescence" |
| 10:10 -10:20 | Discussion |
| 10:20 - 10:35 | Break |
| 10:35 - 11:05 | Hagan Bayley (Texas A&M)
"Pore Planning: Functional Membrane Proteins by Design" |
| 11:05 - 11:15 | Discussion |
| 11:15 - 11:45 | Graeme Robertson (GlaxoWellcome)
"Ion Channel Drug Discovery- Challenges and Opportunities" |
| 11:45 - 11:55 | Discussion |
| 11:55 - 12:10 | Poster VII |
| 12:10 - 12:25 | Poster VIII |
| 7:30 pm | GENOMICS & PROTEOMICS |
| Session Chair: Kurt Deshayes, Genentech |
| 7:15 - 7:45 | Thea Norman (Microbia, Inc.)
"Genetic Selections for Peptide Inhibitors of Biological Pathways" |
| 7:45 - 7:55 | Discussion |
| 7:55 - 8:25 | Ben Cravatt (Scripps)
"Activity-based Protein Profiling: Chemical Approaches for Making Proteomics Functional" |
| 8:25 - 8:35 | Discussion |
| 8:35 - 8:50 | Break |
| 8:50 - 9:20 | Dennis Yamashita (SmithKline Beecham)
"Cathepsin K Inhibitors: Rationale and Design" |
| 9:20 - 9:30 | Discussion |
| FRIDAY |
| 9:00 | Depart |
