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Sunday
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| 2:00 pm - 9:00 pm |
Arrival and Check-in
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| 6:00 pm - 7:00 pm |
Dinner
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| 7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
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| 7:40 pm - 9:30 pm |
Covalent Inhibitors as Drugs
Discussion Leader: Daniel Nomura (University of California, Berkeley, USA)
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| 7:40 pm - 8:05 pm |
Nathanael Gray (Dana Farber Cancer Institute, USA)
"New Pharmacological Approaches to Kinase Inhibitor Discovery: Degradation, Allostery and Covalence"
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| 8:05 pm - 8:10 pm |
Discussion
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| 8:10 pm - 8:25 pm |
Sherry Niessen (Pfizer, USA)
"Applying Chemical Biology Probes for the EGFRT790M Covalent Inhibitor Program"
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| 8:25 pm - 8:30 pm |
Discussion
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| 8:30 pm - 8:45 pm |
Bryan Dickinson (The University of Chicago, USA)
"Chemical Approaches to Probe Signaling by Dynamic Proteome Lipidation"
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| 8:45 pm - 8:50 pm |
Discussion
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| 8:50 pm - 9:05 pm |
Nathanael Lintner (Pfizer, Inc., USA)
"Selective Inhibition of Translation with Small Molecules"
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| 9:05 pm - 9:10 pm |
Discussion
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| 9:10 pm - 9:25 pm |
Jacqueline Blankman (Abide Therapeutics, USA)
"Inhibition of Monoacylglycerol Lipase for the Treatment of Neurological Disorders"
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| 9:25 pm - 9:30 pm |
Discussion
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Monday
|
| 7:30 am - 8:30 am |
Breakfast
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| 9:00 am - 12:30 pm |
Chromatin Modifying Enzymes
Discussion Leader: Champak Chatterjee (University of Washington, USA)
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| 9:00 am - 9:30 am |
James Bradner (Novartis Institutes for BioMedical Research, USA)
"Targeting Epigenomic Complexes"
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| 9:30 am - 9:40 am |
Discussion
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| 9:40 am - 10:10 am |
Philip Cole (Harvard Medical School, USA)
"Targeting Reversible Lys Modifications with Designed Small Molecules"
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| 10:10 am - 10:20 am |
Discussion
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| 10:20 am - 10:50 am |
Coffee Break
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| 10:50 am - 11:20 am |
Danica Fujimori (University of California, San Francisco, USA)
"Regulation and Small Molecule Inhibition of Chromatin Demethylation"
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| 11:20 am - 11:30 am |
Discussion
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| 11:30 am - 11:45 am |
Jordan Meier (National Cancer Institute, NIH, USA)
"An Expanded Landscape of Acetylation in Signaling from Chemoproteomics"
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| 11:45 am - 11:50 am |
Discussion
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| 11:50 am - 12:05 pm |
William Pomerantz (University of Minnesota, USA)
"Fluorinated Proteins as Enabling Tools for Small Molecule Discovery in Epigenetics"
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| 12:05 pm - 12:10 pm |
Discussion
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| 12:10 pm - 12:25 pm |
Kabirul Islam (University of Pittsburgh, USA)
"Protein and Small Molecule Engineering Towards a Programmable Chromatin Landscape"
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| 12:25 pm - 12:30 pm |
Discussion
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| 12:30 pm - 1:30 pm |
Lunch
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| 1:30 pm - 4:00 pm |
Free Time
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| 3:00 pm - 4:00 pm |
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Catherine Leimkuhler Grimes (University of Delaware, USA)
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| 4:00 pm - 6:00 pm |
Poster Session
|
| 6:00 pm - 7:00 pm |
Dinner
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| 7:30 pm - 9:30 pm |
Liganding Undruggable Targets
Discussion Leader: Raymond Moellering (University of Chicago, USA)
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| 7:30 pm - 8:00 pm |
Michelle Arkin (University of California, San Francisco, USA)
"Site-Directed Screening: Harnessing Cysteines to Modulate Challenging Targets"
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| 8:00 pm - 8:10 pm |
Discussion
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| 8:10 pm - 8:40 pm |
Phil Chamberlain (Celgene, USA)
"Expanding the Druggable Proteome Through Cereblon-Mediated Protein Degradation"
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| 8:40 pm - 8:50 pm |
Discussion
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| 8:50 pm - 9:20 pm |
Craig Crews (Yale University, USA)
"PROTACs and Induced Protein Degradation: The 17-Year Old Overnight Phenomenon"
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| 9:20 pm - 9:30 pm |
Discussion
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Tuesday
|
| 7:30 am - 8:30 am |
Breakfast
|
| 8:30 am - 9:00 am |
Group Photo
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| 9:00 am - 12:30 pm |
Chemical Microbiology
Discussion Leader: Stavroula Hatzios (Yale University, USA)
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| 9:00 am - 9:30 am |
Suzanne Walker (Harvard Medical School, USA)
"Using Genome-Wide Mutant Fitness Profiles to Decipher Compound Mechanism"
|
| 9:30 am - 9:40 am |
Discussion
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| 9:40 am - 10:10 am |
Wilfred van der Donk (Howard Hughes Medical Institute / University of Illinois at Urbana-Champaign, USA)
"Leader Peptide Guided Natural Product Biosynthesis"
|
| 10:10 am - 10:20 am |
Discussion
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| 10:20 am - 10:50 am |
Coffee Break
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| 10:50 am - 11:20 am |
Sarah O'Connor (John Innes Centre, United Kingdom)
"Harnessing the Chemistry of Alkaloid-Producing Plants"
|
| 11:20 am - 11:30 am |
Discussion
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| 11:30 am - 11:45 am |
Louise Charkoudian (Haverford College, USA)
"Capturing Transient Interactions of Proteins Involved in Natural Product Biosynthesis"
|
| 11:45 am - 11:50 am |
Discussion
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| 11:50 am - 12:05 pm |
Sarah Slavoff (Yale University, USA)
"Regulated Expression of the (Non-)Annotated Proteome"
|
| 12:05 pm - 12:10 pm |
Discussion
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| 12:10 pm - 12:25 pm |
G. Ekin Atilla-Gokcumen (University at Buffalo, USA)
"Non-Traditional Role of Lipids in Programmed Cell Death"
|
| 12:25 pm - 12:30 pm |
Discussion
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| 12:30 pm - 1:30 pm |
Lunch
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| 1:30 pm - 4:00 pm |
Free Time
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| 4:00 pm - 6:00 pm |
Poster Session
|
| 6:00 pm - 7:00 pm |
Dinner
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| 7:30 pm - 9:30 pm |
Chemical Biology in Drug Discovery
Discussion Leader: Catherine Leimkuhler Grimes (University of Delaware, USA)
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| 7:30 pm - 8:00 pm |
Steven Zimmerman (University of Illinois at Urbana-Champaign, USA)
"New Approaches to the Discovery and Delivery of Agents Targeting RNA-Mediated Disease"
|
| 8:00 pm - 8:10 pm |
Discussion
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| 8:10 pm - 8:40 pm |
Gitte Neubauer (Cellzome GmbH, Germany)
"Chemistry Meets Omics: Understanding How Drugs Work"
|
| 8:40 pm - 8:50 pm |
Discussion
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| 8:50 pm - 9:05 pm |
Kay Ahn (Janssen Research & Development, USA)
"Chemical Biology Approach for Small Molecule Inhibitor Mechanism of Action Studies in Living Cells"
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| 9:05 pm - 9:10 pm |
Discussion
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| 9:10 pm - 9:25 pm |
Jacob Bush (GlaxoSmithKline, United Kingdom)
"PhABits Shine Lght on Fragment-Protein Binding"
|
| 9:25 pm - 9:30 pm |
Discussion
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Wednesday
|
| 7:30 am - 8:30 am |
Breakfast
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| 9:00 am - 12:30 pm |
Imaging and Optochemical Control
Discussion Leader: Ellen Sletten (University of California, Los Angeles, USA)
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| 9:00 am - 9:30 am |
Jin Zhang (University of California, San Diego, USA)
"Illuminating the Biochemical Activity Architecture of the Cell"
|
| 9:30 am - 9:40 am |
Discussion
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| 9:40 am - 10:10 am |
Dirk Trauner (New York University, USA)
"Optical Control of GPCRs and Kinases"
|
| 10:10 am - 10:20 am |
Discussion
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| 10:20 am - 10:40 am |
Coffee Break
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| 10:40 am - 11:10 am |
Alexander Deiters (University of Pittsburgh, USA)
"Optical Control of Protein Function in Cells and Animals"
|
| 11:10 am - 11:20 am |
Discussion
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| 11:20 am - 11:35 am |
Jennifer Heemstra (Emory University, USA)
"Harnessing Nucleic Acid Molecular Recognition for Fluorescence-Based Biomolecular Imaging"
|
| 11:35 am - 11:40 am |
Discussion
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| 11:40 am - 11:55 am |
Elizabeth Sattely (Stanford University, USA)
"Discovery and Engineering Plant Chemistry"
|
| 11:55 am - 12:00 pm |
Discussion
|
| 12:00 pm - 12:10 pm |
Kevin Bicker (Middle Tennessee State University, USA)
"Development of Short Peptoids as Antifungal Agents Against C. neoformans"
|
| 12:10 pm - 12:15 pm |
Discussion
|
| 12:15 pm - 12:25 pm |
Short Talk Selected from Poster Abstracts
|
| 12:25 pm - 12:30 pm |
Discussion
|
| 12:30 pm - 1:30 pm |
Lunch
|
| 1:30 pm - 4:00 pm |
Free Time
|
| 4:00 pm - 6:00 pm |
Poster Session
|
| 6:00 pm - 7:00 pm |
Dinner
|
| 7:00 pm - 7:30 pm |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
| 7:30 pm - 9:30 pm |
Modulating Protein Function
Discussion Leader: Rongsheng (Ross) Wang (Temple University, USA)
|
| 7:30 pm - 8:00 pm |
Benjamin Davis (University of Oxford, United Kingdom)
"Sugars and Proteins"
|
| 8:00 pm - 8:10 pm |
Discussion
|
| 8:10 pm - 8:40 pm |
Herbert Waldmann (Max Planck Institute of Molecular Physiology, Germany)
"Pseudo Natural Products for Phenotypic Small Molecule Discovery"
|
| 8:40 pm - 8:50 pm |
Discussion
|
| 8:50 pm - 9:20 pm |
Shana Kelley (University of Toronto, Canada)
"Identifying and Modulating Mitochondrial Proteins with Organelle-Specific Probes"
|
| 9:20 pm - 9:30 pm |
Discussion
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Thursday
|
| 7:30 am - 8:30 am |
Breakfast
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| 9:00 am - 12:30 pm |
Targeting RNA with Small Molecules
Discussion Leader: Ming Hammond (University of California, Berkeley, USA)
|
| 9:00 am - 9:30 am |
Matthew Disney (The Scripps Research Institute, USA)
"Sequence-Based Design of Small Molecules Targeting RNA"
|
| 9:30 am - 9:40 am |
Discussion
|
| 9:40 am - 10:10 am |
Hashim Al-Hashimi (Duke University, USA)
"Hitting a Moving Target: The Importance of Dynamics in Developing a Predictive Understanding of RNA-Small Molecule Recognition"
|
| 10:10 am - 10:20 am |
Discussion
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| 10:20 am - 10:50 am |
Coffee Break
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| 10:50 am - 11:20 am |
Jennifer Petter (Arrakis Therapeutics, USA)
"RNA-Targeted Small Molecules: A Problem in Drug Discovery"
|
| 11:20 am - 11:30 am |
Discussion
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| 11:30 am - 11:45 am |
Amanda Hargrove (Duke University, USA)
"Deciphering Patterns in Selective Small Molecule: RNA Interactions"
|
| 11:45 am - 11:50 am |
Discussion
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| 11:50 am - 12:05 pm |
Jay Schneekloth (National Cancer Institute, NIH, USA)
"Targeting Structurally and Functionally Diverse RNAs with Druglike Small Molecules"
|
| 12:05 pm - 12:10 pm |
Discussion
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| 12:10 pm - 12:25 pm |
John Howe (Merck & Co., USA)
"Selective Small Molecule Inhibition of an RNA Structural Element"
|
| 12:25 pm - 12:30 pm |
Discussion
|
| 12:30 pm - 1:30 pm |
Lunch
|
| 1:30 pm - 4:00 pm |
Free Time
|
| 4:00 pm - 6:00 pm |
Poster Session
|
| 6:00 pm - 7:00 pm |
Dinner
|
| 7:30 pm - 9:30 pm |
New Chemical Tools to Unlock Biology
Discussion Leader: Darci Trader (Purdue University, USA)
|
| 7:30 pm - 8:00 pm |
Yimon Aye (Cornell University / Weill Cornell Medicine, USA)
"A Twist in the Tail? Precision Electrophile Sensing Guides Isoform-Selective Covalent Ligand Evolution"
|
| 8:00 pm - 8:10 pm |
Discussion
|
| 8:10 pm - 8:40 pm |
Kevin Weeks (University of North Carolina at Chapel Hill, USA)
"Discovering the Pervasive Roles for Structure in ncRNA and mRNA Function"
|
| 8:40 pm - 8:50 pm |
Discussion
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| 8:50 pm - 9:20 pm |
Dorothea Fiedler (Leibniz-Research Institute for Molecular Pharmacology (FMP), Germany)
"Inositol Pyrophosphate Signaling Revealed with Chemical Tools"
|
| 9:20 pm - 9:30 pm |
Discussion
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Friday
|
| 7:30 am - 8:30 am |
Breakfast
|
| 9:00 am |
Departure
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