Translational Chemical Biology

June 9 - 14, 2019

Chairs Jason E. Gestwicki and Paola Castaldi

Vice Chairs Jennifer Heemstra and John Tallarico

Contact Chairs

Proctor Academy

204 Main Street

Andover, NH, US

Venue and Travel Information

Conference Description

The Bioorganic Chemistry Gordon Research Conference (GRC) was established in 1992 to bring together academic and industrial scientists pursuing challenges at the interface of chemistry and biology. The 2019 meeting will focus on the translational aspects of chemical biology. Speakers and participants will illustrate examples of how methods in chemical biology, including synthetic chemistry, cellular and molecular biology, functional genomics, proteomics, biochemistry, biophysics, and computational science have unlocked new opportunities for drug discovery and drug target validation. Special attention will be placed on how global efforts in chemical biology are becoming embedded within the pharmaceutical industry and being used as a core discipline for all translational research. Conferees are encouraged to present posters. Poster presenters should submit an abstract with their applications on the GRC website. In addition, a number of poster presenters will be invited to present short talks. As this meeting usually over-subscribes, submission of applications in early 2019 is strongly encouraged.

Related Meeting

This GRC will be held in conjunction with the "Bioorganic Chemistry (GRS)" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Keynote Session: Translational Chemical Biology Discussion Leader: Ekin Atilla (University at Buffalo, SUNY, USA)
7:40 pm - 8:10 pm	Laura Kiessling (Massachusetts Institute of Technology, USA) "Glycans at the Host-Microbe Interface"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:45 pm	Zaneta Nikolovska-Coleska (University of Michigan Medical School, USA) "Targeting DOT1L Recruitment in MLL-Rearranged Leukemia"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	Jason Sello (Brown University, USA) "Illuminating Protein Homeostasis and Preventing Pathogenesis with Bioactive Small Molecules"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	Michelle Farkas (University of Massachusetts Amherst, USA) "Using Chemical Biology to Interrogate the Connection Between Altered Circadian Rhythms and Cancer"
9:25 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Chemical Probes for Imaging Discussion Leader: Andrew Zhang (AstraZeneca, USA)
9:00 am - 9:30 am	Miles Miller (Massachusetts General Hospital / Harvard Medical School, USA) "Probes for Dissecting In Vivo Pharmacology Using Confocal Microscopy"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	Ralph Mazitschek (Harvard Medical School / Massachusetts General Hospital, USA) "Light-Controlled Modulation of Gene Expression by Chemical Optoepigenetic Probes"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:05 am	Evan Miller (University of California, Berkeley, USA) "Electrophysiology, Unplugged: Fluorescent Tools to Watch Cells in Action"
11:05 am - 11:10 am	Discussion
11:10 am - 11:40 am	Young-Tae Chang (Pohang University of Science and Technology, South Korea) "Strategy for Cell Selective Imaging Probe Development"
11:40 am - 11:50 am	Discussion
11:50 am - 12:05 pm	Ellen Sletten (University of California, Los Angeles, USA) "Multiplexed In Vivo Imaging with Shortwave Infrared Fluorophores"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	Shantanu Singh (Broad Institute of MIT and Harvard, USA) "Accelerating Drug Discovery Through the Power of Microscopy Images"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring. Organizer: Alyson Weidmann (American Chemical Society, USA)
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Automation, Big Data and Machine Learning in Drug Discovery Discussion Leader: Michael Keiser (University of California, San Francisco, USA)
7:30 pm - 8:00 pm	Ian Churcher (BenevolentAI, United Kingdom) "AI-Assisted Drug Discovery: What, How and Why?"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	Bissan Al-Lazikani (Institute of Cancer Research, United Kingdom) "Chemical Probes for Cancer Medicine: The Data and the Data Science"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	Ian Barrett (AstraZeneca, United Kingdom) "Superficial Intelligence: Putting Machine Learning to Work in Drug Discovery"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Probes and Leads: Discovery and Triage Discussion Leader: Bryan Dunyak (ViewPoint Therapeutics, USA)
9:00 am - 9:30 am	Lyn Jones (Jnana Therapeutics, USA) "SLC Transporter Chemical Biology"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	John Overington (Medicines Discovery Catapult, United Kingdom) "Public Data for Chemical Biology: The Past, the Current and the Future"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:05 am	Emily Derbyshire (Duke University, USA) "Chemical Tools for Unraveling Parasite Biology"
11:05 am - 11:10 am	Discussion
11:10 am - 11:40 am	Jack Taunton (University of California, San Francisco, USA) "Small-Molecule Interrogation of Proteostasis"
11:40 am - 11:50 am	Discussion
11:50 am - 12:05 pm	Adam Hendricks (AstraZeneca, USA) "Proteomic Profiling Illuminates Engagement of Higher Order CDKs for an Optimized CDK9 Inhibitor"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	Xiang David Li (The University of Hong Kong, Hong Kong SAR China) "Chemical Approaches to Unravel Mechanisms and Functions of Novel Histone Modifications"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Probes and Leads: Optimization and Application Discussion Leader: Mark Sellmyer (University of Pennsylvania, USA)
7:30 pm - 8:00 pm	Angela Koehler (Massachusetts Institute of Technology, USA) "Attenuating Oncogenic Transcription with Small Molecules"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	David Kokel (University of California, San Francisco, USA) "High-Throughput Behavior Based Neuroactive Drug Discovery in the Zebrafish"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	May Khanna (University of Arizona, USA) "A Chemical Biology Approach to Model a Rare Neurodegenerative Disease"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	Samy Meroueh (Indiana University School of Medicine, USA) "Small-Molecule TEAD-Yap Covalent Antagonists"
9:25 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Application of Omics to Decipher Biology Discussion Leader: Kirti Sharma (Kymera Therapeutics, USA)
9:00 am - 9:30 am	Eranthie Weerapana (Boston College, USA) "Chemical-Proteomic Strategies to Investigate Reactive Cysteines"
9:30 am - 9:35 am	Discussion
9:35 am - 10:05 am	Bernhard Kuster (Technical University of Munich, Germany) "Activity Landscapes of Tumor Cell Lines Reveal Mechanisms of Drug Sensitivity and Resistance"
10:05 am - 10:10 am	Discussion
10:10 am - 10:25 am	Jarrod Marto (Dana Farber Cancer Institute, USA) "Using Funky Fragmentation to Build New Chemoproteomic Assays"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:30 am	Christopher Chang (University of California, Berkeley, USA) "Activity-Based Sensing and Activity-Based Proteomics Approaches to Studying Metal and Redox Biology"
11:30 am - 11:35 am	Discussion
11:35 am - 11:50 am	Monica Schenone (Pfizer, USA) "Identification of p300/CBP as the Cellular Target of the Small Molecule 'BRD16' Following a Phenotypic Screen"
11:50 am - 11:55 am	Discussion
11:55 am - 12:10 pm	Raymond Moellering (University of Chicago, USA) "Pathways and Platforms Spanning Space, Time and Reactivity in the Proteome"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Simone Rauch (The University of Chicago, USA) "Synthetic Biology Approaches to Study and Control the Transcriptome"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm	Looking for Drugs in Unconventional Places Discussion Leader: Keriann Backus (University of California, Los Angeles, USA)
7:30 pm - 8:00 pm	David Sherman (Life Sciences Institute, University of Michigan, USA) "Natural Product Assemblies that Employ Diverse Pericyclic Reactions"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	Emily Balskus (Harvard University, USA) "Deciphering the Human Microbiota Using Chemistry"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	Rob Oslund (Merck Exploratory Science Center, USA) "Mapping of Immunomodulatory Receptor Protein Interactions via Photoactivation-Based Proximity Labeling of the Cell Surface"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Emerging Technologies in Translation Chemical Biology Discussion Leader: Xin Zhang (Pennsylvania State University, USA)
9:00 am - 9:30 am	Keith Wood (Promega Corporation, USA) "Chemical Probes of Intracellular Target Occupancy"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	Daniel Nomura (University of California, Berkeley, USA) "Reimagining Druggability Using Chemoproteomic Platforms"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:05 am	Kilian Huber (University of Oxford, United Kingdom) "Chemical Biology Tools for Target Identification and Validation"
11:05 am - 11:10 am	Discussion
11:10 am - 11:40 am	Matthew Weiss (Kymera Therapeutics, USA) "IRAK4 Degradation with Orally Active Compounds in MYD88 Driven Diseases"
11:40 am - 11:50 am	Discussion
11:50 am - 12:05 pm	Daniel Martinez Molina (Pelago Bioscience, Sweden) "Beyond the Target: CETSA for Pathway Engagement Analysis"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	Yftah Tal-Gan (University of Nevada, Reno, USA) "Peptide-Based Tools to Interrogate Quorum Sensing Signaling in Bacteria"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	RNA and Lipid Biology Discussion Leader: Sarah Keane (University of Michigan, USA)
7:30 pm - 8:00 pm	Thomas Hermann (University of California, San Diego, USA) "RNA as a Drug Target and Material for Nanotechnology"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	Rami Hannoush (Genentech, Inc., USA) "Tuning Stem Cell Receptor Function via Conformational Control"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	Amanda Garner (University of Michigan, USA) "Chemical Probing of Coding and Non-Coding RNA Biology"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	Jeremy Baskin (Cornell University, USA) "Chemical Tools that IMPACT Lipid Signaling"
9:25 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure