Sunday
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2:00 pm - 9:00 pm |
Arrival and Check-in
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
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7:40 pm - 9:30 pm |
Keynote Session: Translational Chemical Biology
Discussion Leader: Ekin Atilla (University at Buffalo, SUNY, USA)
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7:40 pm - 8:10 pm |
Laura Kiessling (Massachusetts Institute of Technology, USA)
"Glycans at the Host-Microbe Interface"
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8:10 pm - 8:15 pm |
Discussion
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8:15 pm - 8:45 pm |
Zaneta Nikolovska-Coleska (University of Michigan Medical School, USA)
"Targeting DOT1L Recruitment in MLL-Rearranged Leukemia"
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8:45 pm - 8:50 pm |
Discussion
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8:50 pm - 9:05 pm |
Jason Sello (Brown University, USA)
"Illuminating Protein Homeostasis and Preventing Pathogenesis with Bioactive Small Molecules"
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9:05 pm - 9:10 pm |
Discussion
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9:10 pm - 9:25 pm |
Michelle Farkas (University of Massachusetts Amherst, USA)
"Using Chemical Biology to Interrogate the Connection Between Altered Circadian Rhythms and Cancer"
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9:25 pm - 9:30 pm |
Discussion
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Monday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Chemical Probes for Imaging
Discussion Leader: Andrew Zhang (AstraZeneca, USA)
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9:00 am - 9:30 am |
Miles Miller (Massachusetts General Hospital / Harvard Medical School, USA)
"Probes for Dissecting In Vivo Pharmacology Using Confocal Microscopy"
|
9:30 am - 9:40 am |
Discussion
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9:40 am - 10:10 am |
Ralph Mazitschek (Harvard Medical School / Massachusetts General Hospital, USA)
"Light-Controlled Modulation of Gene Expression by Chemical Optoepigenetic Probes"
|
10:10 am - 10:20 am |
Discussion
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10:20 am - 10:50 am |
Coffee Break
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10:50 am - 11:05 am |
Evan Miller (University of California, Berkeley, USA)
"Electrophysiology, Unplugged: Fluorescent Tools to Watch Cells in Action"
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11:05 am - 11:10 am |
Discussion
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11:10 am - 11:40 am |
Young-Tae Chang (Pohang University of Science and Technology, South Korea)
"Strategy for Cell Selective Imaging Probe Development"
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11:40 am - 11:50 am |
Discussion
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11:50 am - 12:05 pm |
Ellen Sletten (University of California, Los Angeles, USA)
"Multiplexed In Vivo Imaging with Shortwave Infrared Fluorophores"
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12:05 pm - 12:10 pm |
Discussion
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12:10 pm - 12:25 pm |
Shantanu Singh (Broad Institute of MIT and Harvard, USA)
"Accelerating Drug Discovery Through the Power of Microscopy Images"
|
12:25 pm - 12:30 pm |
Discussion
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12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
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3:00 pm - 4:00 pm |
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizer: Alyson Weidmann (American Chemical Society, USA)
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4:00 pm - 6:00 pm |
Poster Session
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
Automation, Big Data and Machine Learning in Drug Discovery
Discussion Leader: Michael Keiser (University of California, San Francisco, USA)
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7:30 pm - 8:00 pm |
Ian Churcher (BenevolentAI, United Kingdom)
"AI-Assisted Drug Discovery: What, How and Why?"
|
8:00 pm - 8:10 pm |
Discussion
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8:10 pm - 8:40 pm |
Bissan Al-Lazikani (Institute of Cancer Research, United Kingdom)
"Chemical Probes for Cancer Medicine: The Data and the Data Science"
|
8:40 pm - 8:50 pm |
Discussion
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8:50 pm - 9:20 pm |
Ian Barrett (AstraZeneca, United Kingdom)
"Superficial Intelligence: Putting Machine Learning to Work in Drug Discovery"
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9:20 pm - 9:30 pm |
Discussion
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Tuesday
|
7:30 am - 8:30 am |
Breakfast
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8:30 am - 9:00 am |
Group Photo
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9:00 am - 12:30 pm |
Probes and Leads: Discovery and Triage
Discussion Leader: Bryan Dunyak (ViewPoint Therapeutics, USA)
|
9:00 am - 9:30 am |
Lyn Jones (Jnana Therapeutics, USA)
"SLC Transporter Chemical Biology"
|
9:30 am - 9:40 am |
Discussion
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9:40 am - 10:10 am |
John Overington (Medicines Discovery Catapult, United Kingdom)
"Public Data for Chemical Biology: The Past, the Current and the Future"
|
10:10 am - 10:20 am |
Discussion
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10:20 am - 10:50 am |
Coffee Break
|
10:50 am - 11:05 am |
Emily Derbyshire (Duke University, USA)
"Chemical Tools for Unraveling Parasite Biology"
|
11:05 am - 11:10 am |
Discussion
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11:10 am - 11:40 am |
Jack Taunton (University of California, San Francisco, USA)
"Small-Molecule Interrogation of Proteostasis"
|
11:40 am - 11:50 am |
Discussion
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11:50 am - 12:05 pm |
Adam Hendricks (AstraZeneca, USA)
"Proteomic Profiling Illuminates Engagement of Higher Order CDKs for an Optimized CDK9 Inhibitor"
|
12:05 pm - 12:10 pm |
Discussion
|
12:10 pm - 12:25 pm |
Xiang David Li (The University of Hong Kong, Hong Kong SAR China)
"Chemical Approaches to Unravel Mechanisms and Functions of Novel Histone Modifications"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Probes and Leads: Optimization and Application
Discussion Leader: Mark Sellmyer (University of Pennsylvania, USA)
|
7:30 pm - 8:00 pm |
Angela Koehler (Massachusetts Institute of Technology, USA)
"Attenuating Oncogenic Transcription with Small Molecules"
|
8:00 pm - 8:10 pm |
Discussion
|
8:10 pm - 8:40 pm |
David Kokel (University of California, San Francisco, USA)
"High-Throughput Behavior Based Neuroactive Drug Discovery in the Zebrafish"
|
8:40 pm - 8:50 pm |
Discussion
|
8:50 pm - 9:05 pm |
May Khanna (University of Arizona, USA)
"A Chemical Biology Approach to Model a Rare Neurodegenerative Disease"
|
9:05 pm - 9:10 pm |
Discussion
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9:10 pm - 9:25 pm |
Samy Meroueh (Indiana University School of Medicine, USA)
"Small-Molecule TEAD-Yap Covalent Antagonists"
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9:25 pm - 9:30 pm |
Discussion
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Wednesday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Application of Omics to Decipher Biology
Discussion Leader: Kirti Sharma (Kymera Therapeutics, USA)
|
9:00 am - 9:30 am |
Eranthie Weerapana (Boston College, USA)
"Chemical-Proteomic Strategies to Investigate Reactive Cysteines"
|
9:30 am - 9:35 am |
Discussion
|
9:35 am - 10:05 am |
Bernhard Kuster (Technical University of Munich, Germany)
"Activity Landscapes of Tumor Cell Lines Reveal Mechanisms of Drug Sensitivity and Resistance"
|
10:05 am - 10:10 am |
Discussion
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10:10 am - 10:25 am |
Jarrod Marto (Dana Farber Cancer Institute, USA)
"Using Funky Fragmentation to Build New Chemoproteomic Assays"
|
10:25 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:30 am |
Christopher Chang (University of California, Berkeley, USA)
"Activity-Based Sensing and Activity-Based Proteomics Approaches to Studying Metal and Redox Biology"
|
11:30 am - 11:35 am |
Discussion
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11:35 am - 11:50 am |
Monica Schenone (Pfizer, USA)
"Identification of p300/CBP as the Cellular Target of the Small Molecule 'BRD16' Following a Phenotypic Screen"
|
11:50 am - 11:55 am |
Discussion
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11:55 am - 12:10 pm |
Raymond Moellering (University of Chicago, USA)
"Pathways and Platforms Spanning Space, Time and Reactivity in the Proteome"
|
12:10 pm - 12:15 pm |
Discussion
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12:15 pm - 12:25 pm |
Simone Rauch (University of Chicago, USA)
"Synthetic Biology Approaches to Study and Control the Transcriptome"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:00 pm - 7:30 pm |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
7:30 pm - 9:30 pm |
Looking for Drugs in Unconventional Places
Discussion Leader: Keriann Backus (University of California, Los Angeles, USA)
|
7:30 pm - 8:00 pm |
Jon Clardy (Harvard Medical School, USA)
"Microbiome and Natural Products"
|
8:00 pm - 8:10 pm |
Discussion
|
8:10 pm - 8:40 pm |
Emily Balskus (Harvard University, USA)
"Deciphering the Human Microbiota Using Chemistry"
|
8:40 pm - 8:50 pm |
Discussion
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8:50 pm - 9:20 pm |
Rob Oslund (Merck Exploratory Science Center, USA)
"Mapping of Immunomodulatory Receptor Protein Interactions via Photoactivation-Based Proximity Labeling of the Cell Surface"
|
9:20 pm - 9:30 pm |
Discussion
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Thursday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
Emerging Technologies in Translation Chemical Biology
Discussion Leader: Xin Zhang (Pennsylvania State University, USA)
|
9:00 am - 9:30 am |
Keith Wood (Promega Corporation, USA)
"Chemical Probes of Intracellular Target Occupancy"
|
9:30 am - 9:40 am |
Discussion
|
9:40 am - 10:10 am |
Daniel Nomura (University of California, Berkeley, USA)
"Reimagining Druggability Using Chemoproteomic Platforms"
|
10:10 am - 10:20 am |
Discussion
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10:20 am - 10:50 am |
Coffee Break
|
10:50 am - 11:05 am |
Kilian Huber (University of Oxford, United Kingdom)
"Chemical Biology Tools for Target Identification and Validation"
|
11:05 am - 11:10 am |
Discussion
|
11:10 am - 11:40 am |
Matthew Weiss (Kymera Therapeutics, USA)
"IRAK4 Degradation with Orally Active Compounds in MYD88 Driven Diseases"
|
11:40 am - 11:50 am |
Discussion
|
11:50 am - 12:05 pm |
Doug Johnson (Biogen, USA)
"Applications of Clickable Chemical Biology in Drug Discovery"
|
12:05 pm - 12:10 pm |
Discussion
|
12:10 pm - 12:25 pm |
Yftah Tal-Gan (University of Nevada, Reno, USA)
"Peptide-Based Tools to Interrogate Quorum Sensing Signaling in Bacteria"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
RNA and Lipid Biology
Discussion Leader: Sarah Keane (University of Michigan, USA)
|
7:30 pm - 8:00 pm |
Thomas Hermann (University of California, San Diego, USA)
"RNA as a Drug Target and Material for Nanotechnology"
|
8:00 pm - 8:10 pm |
Discussion
|
8:10 pm - 8:40 pm |
Blake Peterson (University of Kansas, USA)
"Fluorogenic Probes for Visualizing Biology"
|
8:40 pm - 8:50 pm |
Discussion
|
8:50 pm - 9:05 pm |
Amanda Garner (University of Michigan, USA)
"Chemical Probing of Coding and Non-Coding RNA Biology"
|
9:05 pm - 9:10 pm |
Discussion
|
9:10 pm - 9:25 pm |
Jeremy Baskin (Cornell University, USA)
"Chemical Tools that IMPACT Lipid Signaling"
|
9:25 pm - 9:30 pm |
Discussion
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Friday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am |
Departure
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