Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Translational Chemical Biology
Discussion Leader: Ziyang Zhang (UC Berkeley, United States)
7:40 pm - 8:10 pm
Stuart Schreiber (Harvard University & Broad Institute, United States)
"The Rise of Molecular Glues and Bifunctional Compounds"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
James Wells (University of California, San Francisco, United States)
"Probing and Attacking the Cell Surface Proteome"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
Short Talk Selected from Poster Abstracts
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Targeted Protein Degradation and Induced Proximity
Discussion Leader: Ekaterina (Katya) Vinogradova (The Rockefeller University, United States)
9:00 am - 9:25 am
Philip Chamberlain (Neomorph, Inc., United States)
"Rational and Systematic Surveys for Novel Glue Discovery"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
Ryan Potts (Amgen, United States)
"Leveraging Proximity-Biology for Innovative Drug Discovery"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Short Talk Selected from Poster Abstracts
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Gonçalo Bernardes (University of Cambridge, United Kingdom)
"Proximity-Induced Nucleic Acid Degrader (PINAD) Approach to Targeted RNA Degradation Using Small Molecules"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Short Talk Selected from Poster Abstracts
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Poster Previews
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Catherine Leimkuhler Grimes (University of Delaware, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cellular Imaging Probes
Discussion Leader: Sierra Williams (Keck Science Department (Scripps, Pitzer, and Claremont McKenna College), United States)
7:30 pm - 7:55 pm
Yamuna Krishnan (University of Chicago, United States)
"Quantitative Chemical Imaging of Organelles"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Alanna Schepartz (University of California, Berkeley, United States)
"Delivery, Delivery, Delivery!"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Short Talk Selected from Poster Abstracts
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Short Talk Selected from Poster Abstracts
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Using Chemical Biology for Serendipitous Discoveries
Discussion Leader: Laura Dassama (Stanford University, United States)
9:00 am - 9:25 am
Jack Taunton (University of California, San Francisco, United States)
"Molecular Logic of Client-Selective Sec61 Inhibition"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
Michelle Arkin (University of California, San Francisco, United States)
"Stabilizing Native Protein-Protein Interactions with Molecular Glues"
9:55 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:55 am
Jonathan Long (Stanford University, United States)
"Chemical Control of Metabolism by Amino Acid-Derived Metabolites"
10:55 am - 11:00 am
Discussion
11:00 am - 11:15 am
Short Talk Selected from Poster Abstracts
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Short Talk Selected from Poster Abstracts
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Nucleic Acids Chemical Biology
Discussion Leader: Nathanael Lintner (Pfizer, United States)
7:30 pm - 7:55 pm
Kevin Weeks (University of North Carolina at Chapel Hill, United States)
"Structure-Based Discovery of New Functions in Large RNAs"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Ming Hammond (University of Utah, United States)
"Riboswitching the Light on Small Molecule Activity in Cells"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
John Schneekloth, Jr. (National Cancer Institute, NIH, United States)
"Targeting RNA Using Artificial Intelligence and Experiment"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
Short Talk Selected from Poster Abstracts
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Omics in Disease Biology
Discussion Leader: Euna Yoo (National Cancer Institute, NIH, United States)
9:00 am - 9:25 am
Keriann Backus (University of California, Los Angeles, United States)
"Multi-Omic Approaches to Stratify the Cysteinome"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
Eranthie Weerapana (Boston College, United States)
"Chemical-Proteomic Strategies to Investigate Reactive Cysteines"
9:55 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:55 am
Chu Wang (Peking University, China)
"Chemical and Computational Proteomics for Functional Target Discovery"
10:55 am - 11:00 am
Discussion
11:00 am - 11:15 am
Short Talk Selected from Poster Abstracts
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Short Talk Selected from Poster Abstracts
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Poster Previews
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Glycobiology
Discussion Leader: Steven Banik (Stanford University)
7:30 pm - 7:55 pm
Catherine Leimkuhler Grimes (University of Delaware, United States)
"Breaking Down Bacterial Cell Walls to Understand Inflammation"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
Short Talk Selected from Poster Abstracts
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
Short Talk Selected from Poster Abstracts
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Michael Boyce (Duke University School of Medicine, United States)
"Chemical Glycobiology of Mammalian Cell Signaling"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
New Therapeutic Modalities and Emerging Technologies
Discussion Leader: Fleur Ferguson (UCSD, United States)
9:00 am - 9:25 am
Michael Erb (TSRI)
"Chemical Approaches to Drug and Study Chromatin Machinery"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
Jamie Cate (UC Berkeley, United States)
"Engineering the Ribosome to Synthesize New Sequence-Defined Polymers"
9:55 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:55 am
Amit Choudhary (Harvard Medical School / Brigham and Women's Hospital / Broad Institute of MIT and Harvard, United States)
"Protein Editing Using Small Molecules?"
10:55 am - 11:00 am
Discussion
11:00 am - 11:15 am
Short Talk Selected from Poster Abstracts
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Short Talk Selected from Poster Abstracts
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Computational Chemical Biology
Discussion Leader: Karsten Krug (Frontier Medicines, United States)
7:30 pm - 7:55 pm
Nir London (The Weizmann Institute of Science, Israel)
"Polymerization Inducing Chimeras - If You Can't Beat Them, Join Them"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
John Irwin (University of California San Francisco, United States)
"Ultra Large Make-On-Demand Library Docking: Is Bigger Always Better?"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Steffen Renner (Novartis, Switzerland)
"At the Dawn of Insights - Hunting for Compounds with Novel MoAs from Existing Cellular HTS Data with Gray Chemical Matter"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
Short Talk Selected from Poster Abstracts
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure