Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Targeting the Undruggable Proteome
Discussion Leader: Lindsey Lin (University of California, San Francisco, United States)
3:45 pm - 4:20 pm
Michelle Arkin (University of California, San Francisco, United States)
"Learning about Druggability Using Reversibly Covalent Fragments"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chemical Probes to Interrogate Biology
Discussion Leader: Victor Adebomi (University of Washington, United States)
7:30 pm - 7:45 pm
Nick Till (Stanford University, United States)
"TrogoTACs: Bispecific Chimeras for Targeted Protein Transfer"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Krittapas Jantarug (University of Zurich, Switzerland)
"A Far-Red Fluorescent Probe for Detection of Gram-Positive Bacteria in Patient Samples"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Gianna Falcone (University of Pittsburgh, United States)
"Development of Small Molecule and Antibody Adaptors for Programming of Universal CAR T Cells"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Daniel Santana (Duke University, United States)
"Investigation of Photoresponsive Azobenzene as a Structural Modulator of Disease Relevant RNA"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Maggie Chen (Harvard University, United States)
"A Long-Range Recruitment Mechanism for mTORC2 Phosphorylation of Akt"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Riley Sinnott (The University of Chicago, United States)
"Engineering CIRTS to Rebalance Protein Expression in Gene Dosage Disorders"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Emerging Approaches in Chemical Biology
Discussion Leader: Laura Eck (TUM, Germany)
9:00 am - 9:15 am
Mandira Banik (UT Austin, United States)
"Mapping Metabolite- and Metal Ion-Protein Interactomes using Functional DNA-based Proximity Labeling"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Andrii Kyrylchuk (University of California, San Francisco, United States)
"Optimization of Ligand Matching for Acceleration of Ultra-Large-Scale Virtual Screens"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Niamh Morris (Rosalind Franklin Institute and University of Leeds, United Kingdom)
"Autonomous Phenotype-Directed Discovery of Chemical Probes"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Shaifaly Parmar (National Institutes of Health, United States)
"Photochemical Regulation of Translation Via Molecular Recognition-Based Reversible Photo-Crosslinking Probe"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Yuanjin Zhang (Scripps Research, United States)
"Expanding the Ligandable Proteome by Paralog Hopping with Covalent Probes"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Lauren Hagler (Stanford University, United States)
"High-Throughput Methods to Measure RNA Folding Thermodynamics in Cells"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Careers at the Interface of Chemistry and Biology
Discussion Leaders: Stephanie Smelyansky (Massachusetts Institute of Technology, United States) and Henry Kilgore (Whitehead institute for Biomedical Research, United States)
1:30 pm - 2:30 pm
Panel Discussion
Careers at the Interface of Chemistry and Biology
Bonnie Bertolaet (Science Club for Girls, Inc, United States)
Hannah Wastyk (Interface Biosciences, Inc., United States)
Pamela Marino (MarinoPA Consulting, United States)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes