Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Immunological Principles Guiding the Development of Vaccines in Biotherapeutics
Discussion Leader: Johnathan Guest (AstraZeneca, United States)
3:45 pm - 4:25 pm
Francesco Destro (Massachusetts Institute of Technology, United States)
"Systems Engineering for Addressing Critical Challenges in Gene Therapy Manufacturing"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Modalities in Biotherapeutics and Vaccines
Discussion Leader: Elisabet Bjanes (University of California San Diego, United States)
7:30 pm - 7:50 pm
Kim Le (Astrazeneca, United States)
"Design Meets Biology. Engineering Immune Engagers With Potentially Improved Therapeutic Index"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Courtney David (Merck, United States)
"Liposomal Scaffolds to Enable Multimeric Display of Vaccine Antigen"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Wade Kuo (University of Michigan, United States)
"Efficient, Long-Lived, and Targeted Brain Delivery of IgGs Using CD98hc-Targeted Bispecific Antibody Shuttles"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Zekun Shao (University of Minnesota/ Temple University, United States)
"Facilitating Intracellular Therapeutic Delivery in Cancer Cells Using Anti-HSPG2 Antibody"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Rebecca Wilen (University of Texas at Austin, United States)
"Engineering Potent TCR-Based T Cell Engagers for CMV Infection"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Natalie Au (University of Toronto, Canada)
"Evaluation and Optimization of a Nutrient Acquisition Protein as a Putative Antigen for a Gonococcal Vaccine"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
AI/ML in Discovery of Biotherapeutics and Vaccines
Discussion Leader: Xiyan Li (Technical University of Denmark, Denmark)
9:00 am - 9:20 am
Matthew Raybould (University of Oxford, United Kingdom)
"Contextualizing the Developability Risk of Antibodies With Lambda Light Chains Using Enhanced Therapeutic Antibody Profiling"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Jonathan Felix (Keck Graduate Institute, United States)
"Mapping the Impact of Neutralizing Antibodies on Viral Evolution Using Fitness Landscapes"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
Pavan Inguva (Massachusetts Institute of Technology, United States)
"Modeling Strategies for Lipid Nanoparticle Manufacturing"
10:15 am - 10:20 am
Discussion
10:20 am - 10:40 am
Hsin-Ting Chen (University of Michigan, United States)
"Predicting Antibody Developability Properties Using Machine Learning"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Lauren Hong (Duke University, United States)
"Programmable Protein Stabilization With Language Model-Derived Peptide Guides"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Advanced Analytics of Biotherapeutics and Vaccines
Discussion Leader: Josue San Emeterio (Xenocs Inc, United States)
1:30 pm - 1:40 pm
Sophie Shoemaker (University of California, Berkeley, United States)
"Mapping the Conformational Landscape of the Rabies Virus Glycoprotein"
1:40 pm - 1:45 pm
Discussion
1:45 pm - 1:55 pm
Zachary Oberholtzer (Regeneron, United States)
"Measuring Antibody-Ligand Complex Size in Serum by Fluorescence Correlation Spectroscopy"
1:55 pm - 2:00 pm
Discussion
2:00 pm - 2:10 pm
Yaqi Wu (University of Kansas, United States)
"Near UV and Visible Light-Induced Degradation of Disulfide-Containing Proteins Mediated by Citrate Buffer and Fe(III): Reduction vs. Oxidation Pathways"
2:10 pm - 2:15 pm
Discussion
2:15 pm - 2:25 pm
Krystian Ganko (Massachusetts Institute of Technology, United States)
"3D Holography-Based Characterization of Infected Cells in the Two-Stage Continuous Production of a Viral Vaccine"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes