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Bones and Teeth

Gordon Research Conference

From Skeletal and Dental Stem Cells to Rare Bone Diseases and Integrative Physiology

January 28 - February 2, 2018

Chair Fanxin Long

Vice Chair Vicki Rosen

Grand Galvez

2024 Seawall Boulevard

Galveston, TX, United States

Venue and Travel Information

Conference Description

The past several years have witnessed a surging interest in studying the skeleton as an integral component of whole-body physiology, and such studies have uncovered novel regulatory circuitries between the skeletal and the neuronal or the metabolic systems. Such findings have underscored the intimate connection between skeletal and overall health. In addition, new insights about the cellular origin and molecular regulation of skeletal and dental stem cells are being provided at a record pace and studies of rare bone diseases have produced unprecedented progress in both mechanistic understanding and potential therapeutics. The 2018 GRC is designed to showcase the latest discoveries in Skeletal and Dental Stem Cells, Craniofacial Biology, Skeletal Aging, Rare Bone Diseases and Integrative Skeletal Physiology, among other important topics. Besides the invited speakers, approximately 20 short talks will be selected from submitted abstracts. Support from the conference budget will be available to support junior scientists including students, postdocs and early career investigators.

Related Meeting

This GRC will be held in conjunction with the "Bones and Teeth" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
4:00 pm - 8:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Mesenchymal Stem Cells and Progenitors Discussion Leader: Pamela Robey (National Institute of Dental and Craniofacial Research, NIH, USA)
7:40 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:10 pm	Henry Kronenberg (Massachusetts General Hospital and Harvard Medical School, USA) "Growth-Associated Skeletal Progenitors"
8:10 pm - 8:20 pm	Discussion
8:20 pm - 8:45 pm	Deneen Wellik (University of Michigan Medical School, USA) "Hox Genes and the Developmental Origin of Skeletal Mesenchymal Stem/Progenitor Cells (MSCs)"
8:45 pm - 8:55 pm	Discussion
8:55 pm - 9:20 pm	Yang Chai (University of Southern California, USA) "Bi-Directional Interaction Between Mesenchymal Stem Cells and Transit Amplifying Cells in Mesenchymal Tissue Homeostasis"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Molecular Regulation of Bone and Tooth Development and Homeostasis Discussion Leader: Bjorn Olsen (Harvard School of Dental Medicine, USA)
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:30 am	David Ornitz (Washington University in St. Louis, USA) "Fibroblast Growth Factors: Critical Regulators of Osteogenic and Chondrogenic Growth Programs"
9:30 am - 9:40 am	Discussion
9:40 am - 10:05 am	Paul Trainor (Stowers Institute for Medical Research, USA) "Neural Crest Cells and Their Roles in Cranioskeletal Development and the Pathogenesis of Ribosomopathies"
10:05 am - 10:15 am	Discussion
10:15 am - 10:25 am	Selected from Poster Abstracts: Diana Carlone (Boston Children's Hospital, USA) "CFP1 Is a Critical Regulator of Skeletal Development"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:25 am	Rosa Serra (University of Alabama at Birmingham, USA) "TGF-β, Novel Roles in Tooth Development"
11:25 am - 11:35 am	Discussion
11:35 am - 12:00 pm	Marie Demay (Massachusetts General Hospital, USA) "Nutritional Regulation of BMSC Lineage Selection and Bone Formation"
12:00 pm - 12:10 pm	Discussion
12:10 pm - 12:20 pm	Selected from Poster Abstracts: Wentian Yang (Alpert Medical School, Brown University, USA) "Osteogenic Commitment of Mesenchymal Progenitors and Osteoblast Maturation Requires PTPN11"
12:20 pm - 12:25 pm	Discussion
12:25 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	Power Hour The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. Organizers: Vicki Rosen (Harvard School of Dental Medicine, USA) and Marie Demay (Massachusetts General Hospital, USA)
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Skeletal Aging and Regeneration Discussion Leader: Lynda Bonewald (Indiana University, USA)
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 8:00 pm	Matthew Silva (Washington University School of Medicine, USA) "Response of Bone to Mechanical Loading – Wnts, Aging and Cell Proliferation"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:35 pm	Charles O'Brien (University of Arkansas for Medical Sciences, USA) "The Contribution of Osteocyte Malfunction to Skeletal Aging"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	Selected from Poster Abstracts: Francesca Mariani (University of Southern California, USA) "Hedgehog Signaling Is Required to Generate Hybrid Cartilage-Bone Cells During Large Scale Skeletal Regeneration"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	Selected from Poster Abstracts: Yuji Mishina (University of Michigan School of Dentistry, USA) "Coordinating Tissue Regeneration Through TGF-β Activated Kinase 1 (TAK1) In-Activation and Re-Activation"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	Selected from Poster Abstracts: Benjamin Alman (Duke University, USA) "Macrophage Cells Secrete Factors that Orchestrate the Rejuvenation of Bone Repair"
9:25 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Genetic Basis for Rare Bone Diseases Discussion Leader: Brendan Lee (Baylor College of Medicine, USA)
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:30 am	Eileen Shore (Perelman School of Medicine, University of Pennsylvania, USA) "Heterotopic Ossification and Fibrodysplasia Ossificans Progressiva (FOP)"
9:30 am - 9:40 am	Discussion
9:40 am - 10:05 am	Kenneth White (Indiana University School of Medicine, USA) "Crossover Mineral Metabolism: Revealing Novel Control of FGF23"
10:05 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 11:10 am	Ernesto Canalis (UConn Health, USA) "Experimental Models of Hajdu Cheney Syndrome and Related Disorders"
11:10 am - 11:20 am	Discussion
11:20 am - 11:45 am	Maurizio Pacifici (The Children's Hospital of Philadelphia, USA) "Aberrant Protein Signaling Drives Osteochondroma Formation in Hereditary Multiple Exostoses"
11:45 am - 11:55 am	Discussion
11:55 am - 12:05 pm	Selected from Poster Abstracts: Fabiana Csukasi (David Geffen School of Medicine at UCLA, USA) "Loss of SIK3 Kinase Activity Impairs Degradation of the mTOR Inhibitor DEPTOR and Leads to Abnormalities in Skeletal and Immunological Development"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:20 pm	Selected from Poster Abstracts: Lorin Olson (Oklahoma Medical Research Foundation, USA) "Genetic Interactions Between PDGFRb and the STAT1 Pathway in Rare Bone Diseases"
12:20 pm - 12:25 pm	Discussion
12:25 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Cellular and Molecular Cross-Talk in Bones and Teeth Discussion Leader: Deborah Veis (Washington University School of Medicine, USA)
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 8:00 pm	Yiping Chen (Tulane University, USA) "Molecular Patterning of the Hard Palate"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:35 pm	Elazar Zelzer (Weizmann Institute of Science, Israel) "The Modular Model for Long Bone Morphogenesis"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	Selected from Poster Abstracts: Marina Feigenson (Harvard School of Dental Medicine, USA) "Identifying Factors that Regulate Periosteal Growth"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	Selected from Poster Abstracts: Guak Kim Tan (Shriners Hospitals for Children, USA) "TGF-Beta Signaling Is Sufficient to Prevent Loss of Tendon Cell Fate in a Cell-Autonomous Manner"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	Selected from Poster Abstracts: Yingzi Yang (Harvard School of Dental Medicine, USA) "Induced GnasR201H Expression from the Endogenous Gnas locus Causes Fibrous Dysplasia by Upregulating Wnt/β-Catenin Signaling"
9:25 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Metabolic Regulation of the Skeleton Discussion Leader: Thomas Clemens (Johns Hopkins University, USA)
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:30 am	Ernestina Schipani (University of Michigan, USA) "Choke to Start the Engine: How Impairment of Mitochondrial Function Can Improve Survival of Hypoxic Cells In Vivo"
9:30 am - 9:40 am	Discussion
9:40 am - 10:05 am	Regis O'Keefe (Washington University in St. Louis, USA) "Metabolism, Chondrocytes, and Osteoarthritis"
10:05 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 11:10 am	Geert Carmeliet (KU Leuven, Belgium) "Glucose and Glutamine for Skeletal Cell Survival and Matrix Properties"
11:10 am - 11:20 am	Discussion
11:20 am - 11:45 am	Ryan Riddle (Johns Hopkins University School of Medicine, USA) "Fatty Acid Utilization by Bone"
11:45 am - 11:55 am	Discussion
11:55 am - 12:05 pm	Selected from Poster Abstracts: Mathieu Ferron (Institut de Recherches Cliniques de Montreal, Canada) "Proprotein Convertase Furin Is a Novel Pleiotropic Regulator of Bone Endocrine Functions"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:20 pm	Selected from Poster Abstracts: Courtney Karner (Duke University, USA) "Glutamine Metabolism Is Required for the Maintenance and Specification of Mesenchymal Stem Cells"
12:20 pm - 12:25 pm	Discussion
12:25 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm	Degenerative Joint Diseases and Emerging Therapies Discussion Leader: Xu Cao (Johns Hopkins University, USA)
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 8:00 pm	Matthew Hilton (Duke University School of Medicine, USA) "Elucidating the NOTCH/HES1/IL-6 Signaling Axis in Osteoarthritis"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:35 pm	Noriyuki Tsumaki (Kyoto University, Japan) "Application of iPS Cell Technologies to the Research of Cartilage Diseases"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	Selected from Poster Abstracts: Ling Qin (University of Pennsylvania, USA) "Subchondral Bone Plate Sclerosis During Late Osteoarthritis Is Caused by Loading-Induced Reduction in Sclerostin"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	Selected from Poster Abstracts: Karen Posey (McGovern Medical School, University of Texas Health Science Center at Houston, USA) "mTORC1 Signaling in Mutant Cartilage Oligomeric Matrix Protein (COMP) Pathology - Potential Novel Therapeutic Target"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	Selected from Poster Abstracts: Joohyun Lim (Baylor College of Medicine, USA) "Loss of Fkbp10 in Murine Tendon Induces Postnatal Joint Contractures and Reduced Collagen Cross-Linking"
9:25 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Integrative Physiology of the Skeleton Discussion Leader: Fanxin Long (Washington University School of Medicine, USA)
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:30 am	Gerard Karsenty (Columbia University Medical Center, USA) "The Functions of Bone"
9:30 am - 9:40 am	Discussion
9:40 am - 10:05 am	Steven Teitelbaum (Washington University School of Medicine, USA) "From the Osteoclast to Obesity Prevention"
10:05 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 11:10 am	Clifford Rosen (Maine Medical Center Research Institute, USA) "The Role of the Bone Marrow Adipocyte in Energy Homeostasis"
11:10 am - 11:20 am	Discussion
11:20 am - 11:45 am	Theresa Guise (Indiana University, USA) "Cancer, Bone, Muscle and Metabolism: What's the Connection?"
11:45 am - 11:55 am	Discussion
11:55 am - 12:05 pm	Selected from Poster Abstracts: Wan-ju Li (University of Wisconsin-Madison, USA) "Bone Morphogenetic Protein-6 Regulates Type 1 Diabetes Mellitus-Associated Bone Loss"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:20 pm	Selected from Poster Abstracts: Philip Trackman (School of Dental Medicine, Boston University, USA) "Lysyl Oxidase Regulation Is a Critical Determinant of Diabetic Osteopenia"
12:20 pm - 12:25 pm	Discussion
12:25 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Targeting Key Signaling Pathways for Therapy Discussion Leader: Aris Economides (Regeneron Pharmaceuticals, Inc., USA)
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 8:00 pm	Bart Williams (Van Andel Research Institute, USA) "Wnt Signaling in Skeletal Development and Homeostasis"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:35 pm	Xue Yuan (Stanford University, USA) "Targeting the Wnt Pathway for Therapeutic Benefits in Bone and Teeth"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	Selected from Poster Abstracts: Takenobu Katagiri (Saitama Medical University, Research Center for Genomic Medicine, Japan) "Characterization of Blocking Antibodies Against ALK2, Which Is a BMP Type I Receptor Associated with FOP"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	Selected from Poster Abstracts: Stavroula Kousteni (Columbia University, USA) "Targeting Signaling Pathways in Osteoblasts as a Treatment for Myelodysplasia and Acute Myeloid Leukemia"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	Selected from Poster Abstracts: Kathryn Cheah (The University of Hong Kong, Hong Kong SAR China) "Inhibiting the Integrated Stress Response Prevents Aberrant Chondrocyte Differentiation and Alleviates Skeletal Defects in Chondrodysplasia"
9:25 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Funding for this conference was made possible (in part) by Grant Number Number 1R13DE027552-01 from the National Institute of Dental and Craniofacial Research and the National Institute of Arthritis and Musculoskeletal and Skin Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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