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Sunday
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| 4:00 pm - 8:00 pm |
Arrival and Check-in
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| 6:00 pm - 7:00 pm |
Dinner
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| 7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
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| 7:40 pm - 9:30 pm |
Mesenchymal Stem Cells and Progenitors
Discussion Leader: Pamela Robey (National Institute of Dental and Craniofacial Research, NIH, USA)
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| 7:40 pm - 7:45 pm |
Introduction by Discussion Leader
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| 7:45 pm - 8:10 pm |
Henry Kronenberg (Massachusetts General Hospital and Harvard Medical School, USA)
"Growth-Associated Skeletal Progenitors"
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| 8:10 pm - 8:20 pm |
Discussion
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| 8:20 pm - 8:45 pm |
Deneen Wellik (University of Michigan Medical School, USA)
"Hox Genes and the Developmental Origin of Skeletal Mesenchymal Stem/Progenitor Cells (MSCs)"
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| 8:45 pm - 8:55 pm |
Discussion
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| 8:55 pm - 9:20 pm |
Yang Chai (University of Southern California, USA)
"Bi-Directional Interaction Between Mesenchymal Stem Cells and Transit Amplifying Cells in Mesenchymal Tissue Homeostasis"
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| 9:20 pm - 9:30 pm |
Discussion
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Monday
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| 7:30 am - 8:30 am |
Breakfast
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| 8:30 am - 9:00 am |
Group Photo
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| 9:00 am - 12:30 pm |
Molecular Regulation of Bone and Tooth Development and Homeostasis
Discussion Leader: Bjorn Olsen (Harvard School of Dental Medicine, USA)
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| 9:00 am - 9:05 am |
Introduction by Discussion Leader
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| 9:05 am - 9:30 am |
David Ornitz (Washington University in St. Louis, USA)
"Fibroblast Growth Factors: Critical Regulators of Osteogenic and Chondrogenic Growth Programs"
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| 9:30 am - 9:40 am |
Discussion
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| 9:40 am - 10:05 am |
Paul Trainor (Stowers Institute for Medical Research, USA)
"Neural Crest Cells and Their Roles in Cranioskeletal Development and the Pathogenesis of Ribosomopathies"
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| 10:05 am - 10:15 am |
Discussion
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| 10:15 am - 10:25 am |
Selected from Poster Abstracts: Diana Carlone (Boston Children's Hospital, USA)
"CFP1 Is a Critical Regulator of Skeletal Development"
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| 10:25 am - 10:30 am |
Discussion
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| 10:30 am - 11:00 am |
Coffee Break
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| 11:00 am - 11:25 am |
Rosa Serra (University of Alabama at Birmingham, USA)
"TGF-β, Novel Roles in Tooth Development"
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| 11:25 am - 11:35 am |
Discussion
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| 11:35 am - 12:00 pm |
Marie Demay (Massachusetts General Hospital, USA)
"Nutritional Regulation of BMSC Lineage Selection and Bone Formation"
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| 12:00 pm - 12:10 pm |
Discussion
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| 12:10 pm - 12:20 pm |
Selected from Poster Abstracts: Wentian Yang (Alpert Medical School, Brown University, USA)
"Osteogenic Commitment of Mesenchymal Progenitors and Osteoblast Maturation Requires PTPN11"
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| 12:20 pm - 12:25 pm |
Discussion
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| 12:25 pm - 12:30 pm |
General Discussion
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| 12:30 pm - 1:30 pm |
Lunch
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| 1:30 pm - 4:00 pm |
Free Time
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| 3:00 pm - 4:00 pm |
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Vicki Rosen (Harvard School of Dental Medicine, USA) and Marie Demay (Massachusetts General Hospital, USA)
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| 4:00 pm - 6:00 pm |
Poster Session
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| 6:00 pm - 7:00 pm |
Dinner
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| 7:30 pm - 9:30 pm |
Skeletal Aging and Regeneration
Discussion Leader: Lynda Bonewald (Indiana University, USA)
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| 7:30 pm - 7:35 pm |
Introduction by Discussion Leader
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| 7:35 pm - 8:00 pm |
Matthew Silva (Washington University School of Medicine, USA)
"Response of Bone to Mechanical Loading – Wnts, Aging and Cell Proliferation"
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| 8:00 pm - 8:10 pm |
Discussion
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| 8:10 pm - 8:35 pm |
Charles O'Brien (University of Arkansas for Medical Sciences, USA)
"The Contribution of Osteocyte Malfunction to Skeletal Aging"
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| 8:35 pm - 8:45 pm |
Discussion
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| 8:45 pm - 8:55 pm |
Selected from Poster Abstracts: Francesca Mariani (University of Southern California, USA)
"Hedgehog Signaling Is Required to Generate Hybrid Cartilage-Bone Cells During Large Scale Skeletal Regeneration"
|
| 8:55 pm - 9:00 pm |
Discussion
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| 9:00 pm - 9:10 pm |
Selected from Poster Abstracts: Yuji Mishina (University of Michigan School of Dentistry, USA)
"Coordinating Tissue Regeneration Through TGF-β Activated Kinase 1 (TAK1) In-Activation and Re-Activation"
|
| 9:10 pm - 9:15 pm |
Discussion
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| 9:15 pm - 9:25 pm |
Selected from Poster Abstracts: Benjamin Alman (Duke University, USA)
"Macrophage Cells Secrete Factors that Orchestrate the Rejuvenation of Bone Repair"
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| 9:25 pm - 9:30 pm |
Discussion
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Tuesday
|
| 7:30 am - 8:30 am |
Breakfast
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| 9:00 am - 12:30 pm |
Genetic Basis for Rare Bone Diseases
Discussion Leader: Brendan Lee (Baylor College of Medicine, USA)
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| 9:00 am - 9:05 am |
Introduction by Discussion Leader
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| 9:05 am - 9:30 am |
Eileen Shore (Perelman School of Medicine, University of Pennsylvania, USA)
"Heterotopic Ossification and Fibrodysplasia Ossificans Progressiva (FOP)"
|
| 9:30 am - 9:40 am |
Discussion
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| 9:40 am - 10:05 am |
Kenneth White (Indiana University School of Medicine, USA)
"Crossover Mineral Metabolism: Revealing Novel Control of FGF23"
|
| 10:05 am - 10:15 am |
Discussion
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| 10:15 am - 10:45 am |
Coffee Break
|
| 10:45 am - 11:10 am |
Ernesto Canalis (UConn Health, USA)
"Experimental Models of Hajdu Cheney Syndrome and Related Disorders"
|
| 11:10 am - 11:20 am |
Discussion
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| 11:20 am - 11:45 am |
Maurizio Pacifici (The Children's Hospital of Philadelphia, USA)
"Aberrant Protein Signaling Drives Osteochondroma Formation in Hereditary Multiple Exostoses"
|
| 11:45 am - 11:55 am |
Discussion
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| 11:55 am - 12:05 pm |
Selected from Poster Abstracts: Fabiana Csukasi (David Geffen School of Medicine at UCLA, USA)
"Loss of SIK3 Kinase Activity Impairs Degradation of the mTOR Inhibitor DEPTOR and Leads to Abnormalities in Skeletal and Immunological Development"
|
| 12:05 pm - 12:10 pm |
Discussion
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| 12:10 pm - 12:20 pm |
Selected from Poster Abstracts: Lorin Olson (Oklahoma Medical Research Foundation, USA)
"Genetic Interactions Between PDGFRb and the STAT1 Pathway in Rare Bone Diseases"
|
| 12:20 pm - 12:25 pm |
Discussion
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| 12:25 pm - 12:30 pm |
General Discussion
|
| 12:30 pm - 1:30 pm |
Lunch
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| 1:30 pm - 4:00 pm |
Free Time
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| 4:00 pm - 6:00 pm |
Poster Session
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| 6:00 pm - 7:00 pm |
Dinner
|
| 7:30 pm - 9:30 pm |
Cellular and Molecular Cross-Talk in Bones and Teeth
Discussion Leader: Deborah Veis (Washington University School of Medicine, USA)
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| 7:30 pm - 7:35 pm |
Introduction by Discussion Leader
|
| 7:35 pm - 8:00 pm |
Yiping Chen (Tulane University, USA)
"Molecular Patterning of the Hard Palate"
|
| 8:00 pm - 8:10 pm |
Discussion
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| 8:10 pm - 8:35 pm |
Elazar Zelzer (Weizmann Institute of Science, Israel)
"The Modular Model for Long Bone Morphogenesis"
|
| 8:35 pm - 8:45 pm |
Discussion
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| 8:45 pm - 8:55 pm |
Selected from Poster Abstracts: Marina Feigenson (Harvard School of Dental Medicine, USA)
"Identifying Factors that Regulate Periosteal Growth"
|
| 8:55 pm - 9:00 pm |
Discussion
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| 9:00 pm - 9:10 pm |
Selected from Poster Abstracts: Guak Kim Tan (Shriners Hospitals for Children, USA)
"TGF-Beta Signaling Is Sufficient to Prevent Loss of Tendon Cell Fate in a Cell-Autonomous Manner"
|
| 9:10 pm - 9:15 pm |
Discussion
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| 9:15 pm - 9:25 pm |
Selected from Poster Abstracts: Yingzi Yang (Harvard School of Dental Medicine, USA)
"Induced GnasR201H Expression from the Endogenous Gnas locus Causes Fibrous Dysplasia by Upregulating Wnt/β-Catenin Signaling"
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| 9:25 pm - 9:30 pm |
Discussion
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Wednesday
|
| 7:30 am - 8:30 am |
Breakfast
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| 9:00 am - 12:30 pm |
Metabolic Regulation of the Skeleton
Discussion Leader: Thomas Clemens (Johns Hopkins University, USA)
|
| 9:00 am - 9:05 am |
Introduction by Discussion Leader
|
| 9:05 am - 9:30 am |
Ernestina Schipani (University of Michigan, USA)
"Choke to Start the Engine: How Impairment of Mitochondrial Function Can Improve Survival of Hypoxic Cells In Vivo"
|
| 9:30 am - 9:40 am |
Discussion
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| 9:40 am - 10:05 am |
Regis O'Keefe (Washington University in St. Louis, USA)
"Metabolism, Chondrocytes, and Osteoarthritis"
|
| 10:05 am - 10:15 am |
Discussion
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| 10:15 am - 10:45 am |
Coffee Break
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| 10:45 am - 11:10 am |
Geert Carmeliet (KU Leuven, Belgium)
"Glucose and Glutamine for Skeletal Cell Survival and Matrix Properties"
|
| 11:10 am - 11:20 am |
Discussion
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| 11:20 am - 11:45 am |
Ryan Riddle (Johns Hopkins University School of Medicine, USA)
"Fatty Acid Utilization by Bone"
|
| 11:45 am - 11:55 am |
Discussion
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| 11:55 am - 12:05 pm |
Selected from Poster Abstracts: Mathieu Ferron (Institut de Recherches Cliniques de Montreal, Canada)
"Proprotein Convertase Furin Is a Novel Pleiotropic Regulator of Bone Endocrine Functions"
|
| 12:05 pm - 12:10 pm |
Discussion
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| 12:10 pm - 12:20 pm |
Selected from Poster Abstracts: Courtney Karner (Duke University, USA)
"Glutamine Metabolism Is Required for the Maintenance and Specification of Mesenchymal Stem Cells"
|
| 12:20 pm - 12:25 pm |
Discussion
|
| 12:25 pm - 12:30 pm |
General Discussion
|
| 12:30 pm - 1:30 pm |
Lunch
|
| 1:30 pm - 4:00 pm |
Free Time
|
| 4:00 pm - 6:00 pm |
Poster Session
|
| 6:00 pm - 7:00 pm |
Dinner
|
| 7:00 pm - 7:30 pm |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
| 7:30 pm - 9:30 pm |
Degenerative Joint Diseases and Emerging Therapies
Discussion Leader: Xu Cao (Johns Hopkins University, USA)
|
| 7:30 pm - 7:35 pm |
Introduction by Discussion Leader
|
| 7:35 pm - 8:00 pm |
Matthew Hilton (Duke University School of Medicine, USA)
"Elucidating the NOTCH/HES1/IL-6 Signaling Axis in Osteoarthritis"
|
| 8:00 pm - 8:10 pm |
Discussion
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| 8:10 pm - 8:35 pm |
Noriyuki Tsumaki (Kyoto University, Japan)
"Application of iPS Cell Technologies to the Research of Cartilage Diseases"
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| 8:35 pm - 8:45 pm |
Discussion
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| 8:45 pm - 8:55 pm |
Selected from Poster Abstracts: Ling Qin (University of Pennsylvania, USA)
"Subchondral Bone Plate Sclerosis During Late Osteoarthritis Is Caused by Loading-Induced Reduction in Sclerostin"
|
| 8:55 pm - 9:00 pm |
Discussion
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| 9:00 pm - 9:10 pm |
Selected from Poster Abstracts: Karen Posey (McGovern Medical School, University of Texas Health Science Center at Houston, USA)
"mTORC1 Signaling in Mutant Cartilage Oligomeric Matrix Protein (COMP) Pathology - Potential Novel Therapeutic Target"
|
| 9:10 pm - 9:15 pm |
Discussion
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| 9:15 pm - 9:25 pm |
Selected from Poster Abstracts: Joohyun Lim (Baylor College of Medicine, USA)
"Loss of Fkbp10 in Murine Tendon Induces Postnatal Joint Contractures and Reduced Collagen Cross-Linking"
|
| 9:25 pm - 9:30 pm |
Discussion
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Thursday
|
| 7:30 am - 8:30 am |
Breakfast
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| 9:00 am - 12:30 pm |
Integrative Physiology of the Skeleton
Discussion Leader: Fanxin Long (Washington University School of Medicine, USA)
|
| 9:00 am - 9:05 am |
Introduction by Discussion Leader
|
| 9:05 am - 9:30 am |
Gerard Karsenty (Columbia University Medical Center, USA)
"The Functions of Bone"
|
| 9:30 am - 9:40 am |
Discussion
|
| 9:40 am - 10:05 am |
Steven Teitelbaum (Washington University School of Medicine, USA)
"From the Osteoclast to Obesity Prevention"
|
| 10:05 am - 10:15 am |
Discussion
|
| 10:15 am - 10:45 am |
Coffee Break
|
| 10:45 am - 11:10 am |
Clifford Rosen (Maine Medical Center Research Institute, USA)
"The Role of the Bone Marrow Adipocyte in Energy Homeostasis"
|
| 11:10 am - 11:20 am |
Discussion
|
| 11:20 am - 11:45 am |
Theresa Guise (Indiana University, USA)
"Cancer, Bone, Muscle and Metabolism: What's the Connection?"
|
| 11:45 am - 11:55 am |
Discussion
|
| 11:55 am - 12:05 pm |
Selected from Poster Abstracts: Wan-ju Li (University of Wisconsin-Madison, USA)
"Bone Morphogenetic Protein-6 Regulates Type 1 Diabetes Mellitus-Associated Bone Loss"
|
| 12:05 pm - 12:10 pm |
Discussion
|
| 12:10 pm - 12:20 pm |
Selected from Poster Abstracts: Philip Trackman (School of Dental Medicine, Boston University, USA)
"Lysyl Oxidase Regulation Is a Critical Determinant of Diabetic Osteopenia"
|
| 12:20 pm - 12:25 pm |
Discussion
|
| 12:25 pm - 12:30 pm |
General Discussion
|
| 12:30 pm - 1:30 pm |
Lunch
|
| 1:30 pm - 4:00 pm |
Free Time
|
| 4:00 pm - 6:00 pm |
Poster Session
|
| 6:00 pm - 7:00 pm |
Dinner
|
| 7:30 pm - 9:30 pm |
Targeting Key Signaling Pathways for Therapy
Discussion Leader: Aris Economides (Regeneron Pharmaceuticals, Inc., USA)
|
| 7:30 pm - 7:35 pm |
Introduction by Discussion Leader
|
| 7:35 pm - 8:00 pm |
Bart Williams (Van Andel Research Institute, USA)
"Wnt Signaling in Skeletal Development and Homeostasis"
|
| 8:00 pm - 8:10 pm |
Discussion
|
| 8:10 pm - 8:35 pm |
Xue Yuan (Stanford University, USA)
"Targeting the Wnt Pathway for Therapeutic Benefits in Bone and Teeth"
|
| 8:35 pm - 8:45 pm |
Discussion
|
| 8:45 pm - 8:55 pm |
Selected from Poster Abstracts: Takenobu Katagiri (Saitama Medical University, Research Center for Genomic Medicine, Japan)
"Characterization of Blocking Antibodies Against ALK2, Which Is a BMP Type I Receptor Associated with FOP"
|
| 8:55 pm - 9:00 pm |
Discussion
|
| 9:00 pm - 9:10 pm |
Selected from Poster Abstracts: Stavroula Kousteni (Columbia University, USA)
"Targeting Signaling Pathways in Osteoblasts as a Treatment for Myelodysplasia and Acute Myeloid Leukemia"
|
| 9:10 pm - 9:15 pm |
Discussion
|
| 9:15 pm - 9:25 pm |
Selected from Poster Abstracts: Kathryn Cheah (The University of Hong Kong, Hong Kong SAR China)
"Inhibiting the Integrated Stress Response Prevents Aberrant Chondrocyte Differentiation and Alleviates Skeletal Defects in Chondrodysplasia"
|
| 9:25 pm - 9:30 pm |
Discussion
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Friday
|
| 7:30 am - 8:30 am |
Breakfast
|
| 9:00 am |
Departure
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