Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Definition, Location, and Function of Stem and Progenitor Cells
Discussion Leader: Christa Maes (KU Leuven, Belgium)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Noriaki Ono (University of Texas Health Science Center at Houston School of Dentistry, United States)
"Growth Plate Stem Cell Actions in Mosaicism"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Deneen Wellik (University of Wisconsin-Madison, United States)
"An Unexpected Role for Hoxa11-Expressing Musculoskeletal Stromal Cells in Muscle"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Ralf Adams (Max Planck Institute for Molecular Biomedicine, Germany)
"Heterogeneity and Functional Specialization of Endothelial Cells in Bone"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Aging and Inflammation
Discussion Leader: Maria Almeida (University of Arkansas for Medical Sciences, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Gabriel Mbalaviele (Washington University School of Medicine in St. Louis, United States)
"Complex Inflammasome-Mediated Inflammatory Responses in Bone Resorption"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Baohong Zhao (Weill Cornell Medical College and Hospital for Special Surgery, United States)
"Pathways Driving Inflammatory Osteoclastogenesis"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Megan Weivoda (Mayo Clinic, United States)
"Osteoclast Functional Heterogeneity During Aging"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Cun-Yu Wang (UCLA, United States)
"Epigenetic Control of Skeletal Aging by KDM4B"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Emily Quarato (University of Rochester, United States)
"High Levels of Efferocytosis by Mesenchymal Stromal Cells Increases their Senescence, Decreases Bone and Causes Myeloid Skewing"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Gareeballah Balla (University of Arkansas for Medical Sciences (UAMS), United States)
"Mitochondrial Protein Deacetylation by SIRT3 Promotes Osteoclast Maturation and Bone Loss in Young Adult Mice Exposed to Low Dose Ionizing Radiation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Megan Weivoda (Mayo Clinic, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Control of Bone and Tooth Development
Discussion Leader: Noriaki Ono (University of Texas Health Science Center at Houston School of Dentistry, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Ernestina Schipani (University of Pennsylvania, United States)
"Mitochondria and the Control of Skeletal Development"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Kim Cooper (University of California, San Diego, United States)
"What Big Feet You Have! Evolution of Skeletal Proportion in Bipedal Jerboas"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Ophir Klein (Cedars-Sinai and University of California San Francisco, United States)
"Development and Renewal of the Dentition Using the Mouse Incisor as a Model"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Jasmin Koehnken Sawall (Children's Hospital of Philadelphia (CHOP), United States)
"An Adipo-Osteo Progenitor Contributes to Bone and Marrow Formation in Adult Mice"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Responding to Mechanical Signals
Discussion Leader: Matthew Silva (Washington University School of Medicine, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Karl Lewis (Cornell University, United States)
"New Tools, New Questions: Recent Advancements in Intravital Studies of Osteocyte Mechanobiology"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Joel Boerckel (University of Pennsylvania, United States)
"Targeting Fracture Gap Oxygenation for Bone Regeneration"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Sarah Calve (University of Colorado Boulder, United States)
"ECM and Biomechanics"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Eileen Shore (University of Pennsylvania School of Medicine, United States)
"Biomechanical Signals and Heterotopic Ossification"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Mizuki Nagata (University of Texas Health Science Center at Houston School of Dentistry, United States)
"Wnt-Directed CXCL12-Expressing Apical Papilla Mesenchymal Progenitor Cells Drive Tooth Root Formation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Bo Shen (National Institute of Biological Sciences, Beijing (NIBS) and Tsinghua University, China)
"Mechanosensitive Osteolectin+ Cells in Skeletal Development and Homeostasis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Regeneration and Repair
Discussion Leader: Megan Killian (University of Michigan, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Anne George (University of Illinois at Chicago, United States)
"Role of DPP in Tissue Regeneration"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Yingzi Yang (Harvard School of Dental Medicine, United States)
"Hedgehog Signaling in Cranial Bone Regeneration"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Thomas Ambrosi (UC Davis, United States)
"Cartilage Regeneration"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Jingxian Zhu (Wuhan University, China)
"Endochondral Repair of Jawbone Defects Using Periosteal Cell Spheroids via Enhanced p38 MAPK Pathway"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Rare Diseases
Discussion Leader: Emma Duncan (King's College London, United Kingdom)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Kelly Wentworth (University of California, San Francisco, United States)
"Fibrous Dysplasia"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Anna Teti (Universita' dell'Aquila, Italy)
"Osteopetrosis: Nosology, Significance and Therapy"
10:10 am - 10:20 am
Discussion
10:20 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Aris Economides (Regeneron Pharmaceuticals, Inc., United States)
"Treatment of FOP"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Monika Weisz-Hubshman (Baylor College of Medicine, United States)
"Recessive Variants in the C-terminal Domain of UFSP2 are Associated with Severe Spondyloepimetaphyseal Dysplasia"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Daniel Ortiz (Inozyme Pharma, United States)
"Preventing Calcification and Improving Bone Health with ENPP1 Enzyme Replacement Therapy: From Bench to Bedside"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Aonjittra Phanrungsuwan (The Ohio State University, United States)
"The Contributions of Osteopontin Phosphorylation to Dentoalveolar Defects in X-linked Hypophosphatemia"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Renny Franceschi (University of Michigan, United States)
"The Collagen Receptor, Discoidin Domain Receptor 2 (DDR2) Regulates BMP-Induced Ossification and Fibrodysplasia Ossificans"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Hormonal Impacts on the Skeleton
Discussion Leader: Murat Bastepe (Massachusetts General Hospital/Harvard Medical Sch, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Marc Wein (Massachusetts General Hospital, United States)
"Intracellular Mediators of PTH Action in Target Tissues"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Janet Crane (Johns Hopkins University, United States)
"Glucocorticoids Impact on the Growing Skeleton"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Murat Bastepe (Massachusetts General Hospital/Harvard Medical Sch, United States)
"Genomic Regulation of the GNAS Gene Expression to Fine-Tune PTH Signaling"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Elizabeth Rico (Crinetics Pharmaceuticals, Inc. - San Diego, CA, United States)
"Blocking Activation of the Parathyroid Hormone Receptor Type 1 (PTH1R) with a Specific and Orally Available Antagonist is a Promising Therapy for the Treatment of Primary Hyperparathyroidism (PHPT)"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Bone Cell Communication
Discussion Leader: Michelle McDonald (Garvan Institute, Australia)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Elazar Zelzer (Weizmann Institute of Science, Israel)
"Tendon-Bone Communication"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Chrissy Hammond (University of Bristol, United Kingdom)
"Modelling Skeletal Ageing Phenotypes in Zebrafish"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Rafiou Agoro (The Jackson Laboratory, United States)
"Single Cell Cortical Bone Transcriptomics Define Novel Osteolineage Gene Sets Altered in Chronic Kidney Disease"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Brian Foster (The Ohio State University, United States)
"Bone Sialoprotein: From Bones to Teeth and Back Again"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Hiroyuki Okada (the University of Tokyo; Harvard School of Dental Medicine, Japan)
"Inclusive Living Subcellular Sequencing by iSCseq Rendering Physical, Physiological and Pathological Features in Osteoclast Diversity"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Zhaoyang Liu (University of Southern California, United States)
"Spatial Transcriptomics Reveals the Crosstalk Between ADGRG6 and SOX9 in Maintaining Chondrocyte Fate and Survival in Postnatal Growth Plates"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cancer and Bone
Discussion Leader: Jesus Delgado-Calle (UAMS, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Hanna Taipaleenmäki (University Hospital, LMU Munich, Germany)
"Osteoblasts as Cellular Targets in Bone Metastasis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Xiang Zhang (Baylor College of Medicine, United States)
"Bone Marrow Niches as Targets of Metastasis and Sources of Systemic Immune Suppression"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Colleen Wu (Duke University, United States)
"Targeting the HIF Signaling Pathway for the Radioprotection of Bone"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure