Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Craniofacial Bone Tissue Engineering: Integrating Biology and Mechanics to Control Stem Cell Fate
Discussion Leader: Hoang-Thai Ha (Université Libre de Bruxelles (ULB), Belgium)
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:20 pm
Warren Grayson (Johns Hopkins University, United States)
"Understanding the Role of Nerves in Bone Regeneration"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Skeletal Development and Regeneration in Cells and Tissue
Discussion Leader: Aris Economides (Regeneron Pharmaceuticals, Inc., United States)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:00 pm
Shawn Hallett (University of Michigan School of Dentistry, United States)
"Conditional Deletion of RUNX2 in Cranial Base Chondrocytes Causes Midfacial Hypoplasia"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:20 pm
Aonjittra Phanrungsuwan (The Ohio State University, United States)
"Local Delivery of Tissue-Nonspecific Alkaline Phosphatase Attenuates Dentoalveolar Defects in the Hyp Mouse Model of X-linked Hypophosphatemia"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
Alicen James (University of Arkansas for Medical Sciences, United States)
"Stimulation of Tfeb: A Master Regulator of Autophagy and Lysosomal Biogenesis in Osteoblast Lineage Cells via CRISPR Activation Increases Bone Mass and Strength"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
Hoang-Thai Ha (Université Libre de Bruxelles (ULB), Belgium)
"Characterization of the Human Dental Pulp Neurovascular System and Its Remodeling at Various Stages of Pulpitis"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
Samantha Costa (MaineHealth Institute for Research, United States)
"PD-L1 Expressing Myeloid Cells Promote Bone Marrow Immunosuppression and Osteoclastogenesis with Diet-Induced Obesity"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
The Discovery and Translation of Emerging Technologies in Skeletal Biology Research
Discussion Leader: Shawn Hallett (University of Michigan School of Dentistry, United States)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:30 am
Hayley Sabol (University of Arkansas for Medical Sciences, United States)
"A New Multimodal Bone-Targeted Therapy to Treat Multiple Myeloma"
9:30 am - 9:35 am
Discussion
9:35 am - 9:50 am
Cristina Sanchez de Diego (University of Wisconsin-Madison, United States)
"Novel Microphysiological Systems for the Study of Prostate Cancer Metastatic Bone Microenvironment"
9:50 am - 9:55 am
Discussion
9:55 am - 10:10 am
Jingxian Zhu (Wuhan University, China)
"Endochondral Repair of Jawbone Defects Using Periosteal Cell Spheroids via Enhanced p38 MAPK Pathway"
10:10 am - 10:15 am
Discussion
10:15 am - 10:30 am
Stefani Gjorcheska (Cincinnati Children's Hospital, United States)
"Aberrant Mineral Regulation in a Zebrafish Model of Waardenburg Syndrome"
10:30 am - 10:35 am
Discussion
10:35 am - 10:50 am
Emily Quarato (University of Rochester, United States)
"High Levels of Efferocytosis by Mesenchymal Stromal Cells Increases Senescence, Decreases Bone and Causes Myeloid Skewing"
10:50 am - 10:55 am
Discussion
10:55 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: A Guide to Impactful Research
Discussion Leader: Samantha Costa (MaineHealth Institute for Research, United States)
1:30 pm - 1:40 pm
Introduction by Discussion Leader
1:40 pm - 2:30 pm
Panel Discussion
Keys to Successful Translation of Academic Research
Pamela Robey (National Institute of Dental and Craniofacial Research, NIH, United States)
Joel Boerckel (University of Pennsylvania, United States)
Eric Ledet (Center for Disability Services // ReVivo Medical, United States)
Nicole Wright (University of Alabama At Birmingham, United States)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes