Sunday
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4:00 pm - 8:00 pm |
Arrival and Check-in
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
|
7:40 pm - 9:30 pm |
Keynote Session: Translating Cancer Genetics and Epigenetics to Therapy
Discussion Leader: Saverio Minucci (European Institute of Oncology, Italy)
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7:40 pm - 8:10 pm |
Ricky Johnstone (Peter MacCallum Cancer Centre, Australia)
"The Role of Transcriptional Cyclin Dependent Kinases in Oncology"
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8:10 pm - 8:15 pm |
Discussion
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8:15 pm - 8:45 pm |
Anjana Rao (La Jolla Insitute for Allergy and Immunology, USA)
"Tet Enzymes in Malignancy"
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8:45 pm - 8:50 pm |
Discussion
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8:50 pm - 9:20 pm |
Elaine Mardis (Institute for Genomic Medicine, Nationwide Children's Hospital, USA)
"Translating Cancer Genomics to Clinical Care"
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9:20 pm - 9:25 pm |
Discussion
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9:25 pm - 9:30 pm |
General Discussion
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Monday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Non-Coding Genome and Cancer
Discussion Leader: Rolf Renne (University of Florida, USA)
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9:00 am - 9:25 am |
Howard Chang (Stanford University, USA)
"Personal Regulome Navigation of Cancer"
|
9:25 am - 9:30 am |
Discussion
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9:30 am - 9:55 am |
Lynne Maquat (School of Medicine and Dentistry, University of Rochester Medical Center, USA)
"Transcriptional Coactivator PGC-1α Provides a Conduit Between DNA-Associated and RNA-Associated Proteins"
|
9:55 am - 10:00 am |
Discussion
|
10:00 am - 10:25 am |
Marcus Peter (Northwestern University, USA)
"Toxic RNAs and Cancer"
|
10:25 am - 10:30 am |
Discussion
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10:30 am - 10:55 am |
Coffee Break
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10:55 am - 11:10 am |
Giovanni Tonon (Fondazione Centro San Raffaele, Italy)
"An Intronic Deletion Triggering a Mitotic Oncogene"
|
11:10 am - 11:15 am |
Discussion
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11:15 am - 11:30 am |
Lizi Wu (University of Florida, USA)
"Long Noncoding RNA Associated with Aberrant LKB1 Signaling"
|
11:30 am - 11:35 am |
Discussion
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11:35 am - 12:00 pm |
Duncan Odom (German Cancer Research Center (DKFZ), Germany / Cancer Research UK Cambridge Institute, United Kingdom)
"Large-Scale Mechanistic Analysis of Tumor Evolution in Livers of Five Rodents"
|
12:00 pm - 12:05 pm |
Discussion
|
12:05 pm - 12:30 pm |
Poster Previews
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:30 pm |
Free Time
|
3:00 pm - 4:00 pm |
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Katherine Chiappinelli (George Washington University, USA) and Maria Figueroa (University of Miami, USA)
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4:30 pm - 6:00 pm |
Poster Session
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6:00 pm - 8:00 pm |
The Cancer Epitranscriptome
Discussion Leader: Jonathan Licht (The University of Florida, USA)
|
6:00 pm - 6:25 pm |
Chuan He (University of Chicago, USA)
"RNA m6A Methylation in Human Cancer"
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6:25 pm - 6:30 pm |
Discussion
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6:30 pm - 6:55 pm |
Francois Fuks (Université Libre de Bruxelles, Belgium)
"The Role of RNA Modifications in Cancer"
|
6:55 pm - 7:00 pm |
Discussion
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7:00 pm - 7:25 pm |
Rolf Renne (University of Florida, USA)
"miRNAs in Viral Oncogenesis"
|
7:25 pm - 7:30 pm |
Discussion
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7:30 pm - 7:55 pm |
Ting Wang (Washington University School of Medicine, USA)
"Transposable Elements in the Normal and Cancer Epigenome"
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7:55 pm - 8:00 pm |
Discussion
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8:00 pm - 9:00 pm |
Dinner
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Tuesday
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7:30 am - 8:30 am |
Breakfast
|
8:30 am - 9:00 am |
Group Photo
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9:00 am - 12:30 pm |
Epigenetic and Genetic Mechanisms
Discussion Leader: Giovanni Tonon (Fondazione Centro San Raffaele, Italy)
|
9:00 am - 9:20 am |
Cigall Kadoch (Dana-Farber Cancer Institute, USA)
"Structure and Function of Mammalian SWI/SNF Complexes in Cancer"
|
9:20 am - 9:25 am |
Discussion
|
9:25 am - 9:45 am |
Katherine Chiappinelli (George Washington University, USA)
"Epigenetic Regulation of Repetitive Elements in Cancer"
|
9:45 am - 9:50 am |
Discussion
|
9:50 am - 10:10 am |
Ashby Morrison (Stanford University, USA)
"Epigenetic Regulation of Carcinogen Susceptibility"
|
10:10 am - 10:15 am |
Discussion
|
10:15 am - 10:40 am |
Coffee Break
|
10:40 am - 11:00 am |
Margaret Goodell (Baylor College of Medicine, USA)
"DNA Methylation Canyons Guide Long-Range Chromosomal Interactions"
|
11:00 am - 11:05 am |
Discussion
|
11:05 am - 11:25 am |
Albert Jeltsch (University of Stuttgart, Germany)
"Flanking Sequence Preferences of the DNMT3A R882H AML Mutation Affect Cellular DNA Methylation Patterns"
|
11:25 am - 11:30 am |
Discussion
|
11:30 am - 11:40 am |
Tao Wu (Baylor College of Medicine, USA)
"Novel DNA Methylation in Cancer"
|
11:40 am - 11:45 am |
Discussion
|
11:45 am - 11:55 am |
Colm Nestor (Linkoping University, Sweden)
"A Reassessment of N6-Methyladenine in Mammalian DNA"
|
11:55 am - 12:00 pm |
Discussion
|
12:00 pm - 12:10 pm |
Chao Lu (Columbia University, USA)
"Histone and DNA Methylation Crosstalk in Developmental and Neoplastic Overgrowth"
|
12:10 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:30 pm |
Poster Previews
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:30 pm |
Free Time
|
4:30 pm - 6:00 pm |
Poster Session
|
6:00 pm - 8:00 pm |
Functional Studies of the Cancer Genome and Epigenome
Discussion Leader: Ashby Morrison (Stanford University, USA)
|
6:00 pm - 6:25 pm |
Ross Levine (Memorial Sloan Kettering Cancer Center, USA)
"Cohesin Complexes in Myeloid Malignancies"
|
6:25 pm - 6:30 pm |
Discussion
|
6:30 pm - 6:55 pm |
Luke Gilbert (University of California, San Francisco, USA)
"Mapping the Genetic Landscape of Human Cells"
|
6:55 pm - 7:00 pm |
Discussion
|
7:00 pm - 7:25 pm |
Constantine Mitsiades (Dana-Farber Cancer Institute, Harvard Medical School, USA)
"Functional Genomic Characterization of Epigenetic Dependencies in Myeloma"
|
7:25 pm - 7:30 pm |
Discussion
|
7:30 pm - 7:55 pm |
Tony Kouzarides (University of Cambridge, United Kingdom)
"Modifications of RNA: Their Function and Role in Cancer"
|
7:55 pm - 8:00 pm |
Discussion
|
8:00 pm - 9:00 pm |
Dinner
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Wednesday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
The Genetics and Epigenetics of Lymphoma and Immuno-Oncology
Discussion Leader: Katherine Chiappinelli (George Washington University, USA)
|
9:00 am - 9:25 am |
Ari Melnick (Weill Cornell Medicine, USA)
"Epigenetic Mechanisms of Lymphomagenesis"
|
9:25 am - 9:30 am |
Discussion
|
9:30 am - 9:55 am |
Elisa Oricchio (École Polytechnique Fédérale de Lausanne, Switzerland)
"Structural and Functional Modifications of the 3D Organization of the Genome in Non-Hodgkin Lymphoma"
|
9:55 am - 10:00 am |
Discussion
|
10:00 am - 10:25 am |
Arianna Sabò (European Institute of Oncology (IEO), Italy)
"An Early Myc-Dependent Transcriptional Program Underlies Enhanced Macromolecular Biosynthesis and Cell Growth During B-Cell Activation"
|
10:25 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:25 am |
Stephen Baylin (Johns Hopkins University, USA)
"The Molecular Underpinnings for Enhancing Immune Checkpoint Therapy with Combinatorial Epigenetic Therapy"
|
11:25 am - 11:30 am |
Discussion
|
11:30 am - 11:55 am |
Peter Jones (Van Andel Institute, USA)
"Epigenetic Therapy and Endogenous Retroviruses"
|
11:55 am - 12:00 pm |
Discussion
|
12:00 pm - 12:25 pm |
Christina Leslie (Memorial Sloan Kettering Cancer Center, USA)
"Decoding Differentiation States in Immune Cells and T Cell Dysfunction in Tumors"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:30 pm |
Free Time
|
4:30 pm - 6:00 pm |
Poster Session
|
6:00 pm - 8:00 pm |
Genome-Wide Studies of Epigenetics and Cancer
Discussion Leader: Albert Jeltsch (University of Stuttgart, Germany)
|
6:00 pm - 6:25 pm |
Mathieu Lupien (Princess Margaret Cancer Centre, Canada)
"Identifying the Noncoding Genetic Drivers of Cancer from Epigenetics"
|
6:25 pm - 6:30 pm |
Discussion
|
6:30 pm - 6:55 pm |
Toshikazu Ushijima (National Cancer Center Research Institute, Japan)
"Epigenetic Fields Induced by Chronic Inflammation: Mechanism of Formation and Clinical Impact"
|
6:55 pm - 7:00 pm |
Discussion
|
7:00 pm - 7:25 pm |
Jindan Yu (Northwestern University, USA)
"Targeting Polycomb Group Proteins in Prostate Cancer"
|
7:25 pm - 7:30 pm |
Discussion
|
7:30 pm - 7:55 pm |
Sohrab Shah (Memorial Sloan Kettering Cancer Center, USA)
"Single Cell Whole Genome Sequencing for Population Genetic Inference of Cancer Dynamics"
|
7:55 pm - 8:00 pm |
Discussion
|
8:00 pm - 9:00 pm |
Dinner
|
Thursday
|
7:30 am - 8:30 am |
Breakfast
|
8:30 am - 9:00 am |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
9:00 am - 12:30 pm |
Computational Approaches and Genome-Wide Approaches to Cancer Genetics and Epigenetics
Discussion Leader: Jindan Yu (Northwestern University, USA)
|
9:00 am - 9:25 am |
Kai Tan (University of Pennsylvania, USA)
"Systematic Identification of Synergistic Regulators as Targets for Combination Therapy"
|
9:25 am - 9:30 am |
Discussion
|
9:30 am - 9:55 am |
Maria Figueroa (University of Miami, USA)
" Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers that May Predispose to Leukemia"
|
9:55 am - 10:00 am |
Discussion
|
10:00 am - 10:25 am |
Jane Skok (New York University, USA)
"CTCFL and Its Impact on Gene Regulation and Interplay with CTCF Function"
|
10:25 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:20 am |
Michael Keogh (EpiCypher Inc, USA)
"Fixing ChIP with Next-Generation Spike-in Controls"
|
11:20 am - 11:25 am |
Discussion
|
11:25 am - 11:35 am |
Galina Selivanova (Karolinska Institutet, Sweden)
"Mutant p53 Controls Epigenetic Program Promoting Cancer"
|
11:35 am - 11:40 am |
Discussion
|
11:40 am - 11:50 am |
Alessandro Gardini (The Wistar Institute, USA)
"A Role for Nuclear PP2A in Transcriptional Regulation"
|
11:50 am - 11:55 am |
Discussion
|
11:55 am - 12:05 pm |
Feyruz Rassool (University of Maryland, USA)
"Marrying Drug-Induction of Viral Mimicry, the Inflammasome and DNA Repair Defects in Cancer"
|
12:05 pm - 12:10 pm |
Discussion
|
12:10 pm - 12:20 pm |
Richard Bennett (UF Health Cancer Center, University of Florida, USA)
"A Mutation in the Core of Histone H2B Represents a New Class of Oncogenic Drivers"
|
12:20 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:30 pm |
Free Time
|
4:30 pm - 6:00 pm |
Poster Session
|
6:00 pm - 8:00 pm |
Cancer and the 4D Nucleome
Discussion Leader: Jane Skok (New York University, USA)
|
6:00 pm - 6:25 pm |
Peter Fraser (Florida State University, USA)
"3D Genome Dynamics"
|
6:25 pm - 6:30 pm |
Discussion
|
6:30 pm - 6:55 pm |
Ana Pombo (Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Germany)
"Genome Architecture"
|
6:55 pm - 7:00 pm |
Discussion
|
7:00 pm - 7:25 pm |
Hui Shen (Van Andel Research Institute, USA)
"Decoding Genome-Scale Epigenetic Alterations in Cancer"
|
7:25 pm - 7:30 pm |
Discussion
|
7:30 pm - 7:40 pm |
Giovanni Ciriello (University of Lausanne, Switzerland)
"Exploring Complete Chromatin Architecture"
|
7:40 pm - 7:45 pm |
Discussion
|
7:45 pm - 7:55 pm |
Jüri Reimand (Ontario Institute for Cancer Research, Canada)
"Candidate Cancer Driver Mutations in Distal Regulatory Elements and Long-Range Chromatin Interaction Networks"
|
7:55 pm - 8:00 pm |
Discussion
|
8:00 pm - 9:00 pm |
Dinner
|
Friday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am |
Departure
|