| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Keynote Lectures |
| Discussion Leader: Gerard Evan (UCSF) |
| 7:40 pm - 8:25 pm | Marc Vidal (Dana-Farber Cancer Institute)
"Cancer Systems Biology" |
| 8:25 pm - 8:35 pm | Discussion |
| 8:35 pm - 9:20 pm | Chris Contag (Stanford)
"Advances in Molecular Imagiing" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Flies and Worms I |
| Discussion Leader: Gary Ruvkun (Massachusetts General Hospital) |
| 9:00 am - 9:50 am | Tian Xu (Yale)
"Deciphering Genetic Basis of Tumor Growth and Metastasis" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break / Group Photo |
| 10:30 am - 11:20 am | Chris Bakal (Harvard)
"Defining the Components Of Local Signaling Networks That Regulate Cell Morphology Using Quantitative Morphological Signatures" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:20 pm | Gino Poulin (Univ. of Manchester)
"Attenuation mechanisms of EGFR signalling in C. elegans" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | Flies and Worms II |
| Discussion Leader: Tian Xu (Yale) |
| 5:30 pm - 6:20 pm | Gary Ruvkun (Massachusetts General Hospital)
"Cell division regulation by the C. elegans RNAi and miRNA pathway" |
| 6:20 pm - 6:30 pm | Discussion |
| 6:30 pm - 7:20 pm | Jo Anne Powell Coffman (Iowa State University)
"Genetic analyses of HIF-1 regulatory networks in C. elegans" |
| 7:20 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Frogs and Fish I |
| Discussion Leader: Edwin Cuppen (Netherlands Institute for Developmental Biology) |
| 9:00 am - 9:50 am | Stephano Piccolo (Univ of Padua)
"Regulation of TGF-beta signaling in development and cancer" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 11:20 am | Jean Gautier (Columbia)
"Maintenance of genome stability during DNA replication" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:20 pm | Craig Ceol (Harvard)
"RAS pathway-generated binucleate melanocytes as intermediates in melanoma formation" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | Frogs and Fish II |
| Discussion Leader: Jackie Lees (MIT) |
| 5:30 pm - 6:20 pm | Keith Cheng (Penn State)
"Forward genetic approaches to genomic instability using zebrafish" |
| 6:20 pm - 6:30 pm | Discussion |
| 6:30 pm - 7:20 pm | Edwin Cuppen (Netherlands Institute for Developmental Biology)
"Generation and characterization of novel mismatch
repair-deficient models in the rat and zebrafish" |
| 7:20 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Mice and Men I |
| Discussion Leader: Wilhelm Krek (ETH Zurich) |
| 9:00 am - 9:50 am | Jackie Lees (MIT)
"Bmi1 in Lung Cancer" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 11:20 am | Andreas Trumpp (ISREC)
"Normal Myc function in stem cells and cancer" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:20 pm | Alan Clarke (Cardiff)
"Wnt pathway deregulation in the mouse small intestine" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | Mice and Men II |
| Discussion Leader: Jackie Lees (MIT) |
| 5:30 pm - 6:20 pm | Ned Sharpless (UNC)
"RAS-RAF-ERK signaling, senescence and murine melanoma" |
| 6:20 pm - 6:30 pm | Discussion |
| 6:30 pm - 7:20 pm | Gerard Evan (UCSF)
"Triggering tumor suppression in vivo" |
| 7:20 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Mice and Men II |
| Discussion Leader: Ned Sharpless (UNC) |
| 9:00 am - 9:50 am | Wilhelm Krek (ETH Zurich)
"The von Hippel-Lindau tumor suppressor and the primary cilium" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 11:20 am | David Livingston (Dana-Farber Cancer Institute)
"Functional analysis of the BRCA gene products" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:20 pm | Rene Bernards (NKI)
"Understanding mechanisms of drug resistance using functional genetic
approaches" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | Chemistry and Nanotechnology |
| Discussion Leader: David Livingston (DFCI) |
| 5:30 pm - 6:20 pm | Tarun Kapoor (MSKCC)
"Chemical biology of Cell Division" |
| 6:20 pm - 6:30 pm | Discussion |
| 6:30 pm - 7:20 pm | Anne Leyrat (Stanford)
"Analyzing Cancer at the Single Molecule and Single Cell Level" |
| 7:20 pm - 7:30 pm | Discussion |
| 7:30 pm - 8:00 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 8:00 pm | Dinner |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
