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Carbohydrate-Active Enzymes for Glycan Conversions (GRS)

Gordon Research Seminar

Molecular Determinants of CAZyme Action

July 20 - 21, 2019

Chair Julie Grondin

Contact Chairs

Proctor Academy

204 Main Street

Andover, NH, US

Venue and Travel Information

Conference Description

The Gordon Research Seminar on Carbohydrate-Active Enzymes for Glycan Conversions is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

This year, we aim to showcase the latest insights into the molecular determinants governing the actions of unique CAZymes. This seminar will feature contributions on a range of topics including the enzymology and structure-function analysis of novel hydrolytic and oxidative CAZymes and their associated modules, the discovery and analysis of complex multi-protein systems responsible for glycan saccharification, and the discussion of emerging tools for the study and application of CAZymes and CBMs. Attendees will have the opportunity to share and discuss their current research and build informal networks with senior academic mentors in a relaxed setting prior to the associated GRC, where active participation will be encouraged.

Related Meeting

This GRS will be held in conjunction with the "Carbohydrate-Active Enzymes for Glycan Conversions" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
2:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm	Mining for CAZymes from Diverse Ecosystems Discussion Leader: Stephen Lillington (University of California, Santa Barbara, USA)
3:45 pm - 3:50 pm	Introduction by Discussion Leader
3:50 pm - 4:05 pm	Juliana Sanchez Alponti (University of York, United Kingdom) "Mining for Enzymes Able to Degrade Recalcitrant Biomass from a Salt Marsh Environment"
4:05 pm - 4:10 pm	Discussion
4:10 pm - 4:25 pm	Kristin Low (Agriculture and Agri-Food Canada, Canada) "Increasing the Digestibilty of Non-Starch Dietary Polysaccharides with CAZymes Bioprospected from the Chicken Intestinal Microbiome"
4:25 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Complex Systems for Carbohydrate Degradation Discussion Leader: Jonathon Briggs (University of British Columbia, Canada)
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:00 pm	Rebecca Pollet (University of Michigan Medical School, USA) "The Role of TonB in Polysaccharide Utilization by the Bacteroidetes"
8:00 pm - 8:05 pm	Discussion
8:05 pm - 8:25 pm	Kazune Tamura (University of British Columbia, Canada) "Holistic Molecular Dissection of Beta-Glucan Utilization by Prominent Human Gut Symbionts"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	Filipe Cerqueira (The University of Michigan, USA) "Molecular Features of Resistant Starch Degradation by R. bromii: A Keystone Species of the Gut Microbiome"
8:50 pm - 8:55 pm	Discussion
8:55 pm - 9:15 pm	Chelsea Vickers (Thompson Rivers University, Canada) "Towards Understanding the Microbial Metabolism of Lambda-Carrageenan, One of the Most Highly Sulfated Polysaccharides in Nature"
9:15 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	General Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Mechanistic Insights into CAZyme Action Discussion Leader: Johanna Karppi (Aalto University, Finland)
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:30 am	Tobias Tandrup (University of Copenhagen, Denmark) "Structural Determination of Lytic Polysaccharide Monooxygenase Interactions with Substrate"
9:30 am - 9:35 am	Discussion
9:35 am - 9:55 am	Cecelia Garcia (University of Maryland, USA) "Trehalose Metabolism in Cellvibrio japonicus Exhibits No Functional Redundancy and Is Solely Dependent on the Tre37A Enzyme"
9:55 am - 10:00 am	Discussion
10:00 am - 10:20 am	Shritama Aich (Indian Institute of Science Education and Research (IISER), India) "Engineering the Catalytic Efficiency of a Highly Stable Endoglucanase from the GH7 Family from the Hemibiotrophic Plant Pathogen Bipolaris sorokiniana"
10:20 am - 10:25 am	Discussion
10:25 am - 10:45 am	Olanrewaju Raji (University of Toronto, Canada) "Synergistic Action of Carbohydrate Esterase and α-Glucuronidase in Disassembly of Lignin-Carbohydrate Complexes"
10:45 am - 10:50 am	Discussion
10:50 am - 11:00 am	General Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	CAZyme Applications in Bio-Product Production Discussion Leader: Greta Reintjes (Agriculture and Agri-Food Canada, Canada)
1:30 pm - 1:40 pm	Introduction by Discussion Leader
1:40 pm - 2:00 pm	Maria Cleveland (University of British Columbia, Canada) "Investigating Catalytic Diversity in Copper Radical Oxidases for Bio-Product Production"
2:00 pm - 2:05 pm	Discussion
2:05 pm - 2:25 pm	Filip Mollerup (Aalto University, Finland) "Lytic Polysaccharide Monooxygenase Presents a Unique Capacity for Copper-Catalysed Kirmse Rearrangements in Organic Synthesis"
2:25 pm - 2:30 pm	Discussion
2:30 pm - 3:00 pm	Evaluation Period Fill in GRS Evaluation Forms
3:00 pm	Seminar Concludes

Contributors

This material is based upon work supported by the U.S. Department of Energy, Office of Science, Office of Science under Award Number(s) DE-SC0019738. This report was prepared as an account of work sponsored by an agency of the United States Government. Neither the United States Government nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise does not necessarily constitute or imply its endorsement, recommendation, or favoring by the United States Government or any agency thereof. The views and opinions of authors expressed herein do not necessarily state or reflect those of the United States Government or any agency thereof.

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Conference History Carbohydrate-Active Enzymes for Glycan Conversions

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