Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Glycans in COVID-19 and Other Emerging Diseases
Discussion Leader: Steven Townsend (Vanderbilt University, United States)
7:40 pm - 8:05 pm
Jason McLellan (The University of Texas at Austin, United States)
"The Roles of Glycans on Coronavirus and Pneumovirus Fusion Glycoproteins"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Max Crispin (University of Southampton, United Kingdom)
"Exploiting Pathogen Immune Evasion Strategies in Vaccine Design and Therapeutics"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Catherine Leimkuhler Grimes (University of Delaware, United States)
"Bacterial Peptidoglycan Probes for the Innate Immune System"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Chemical Synthesis of Complex Glycans
Discussion Leader: Pavel Nagorny (University of Michigan, United States)
9:00 am - 9:25 am
M. Carmen Galan (University of Bristol, United Kingdom)
"Catalytic Methods for the Synthesis of Deoxyglycoside Probes to Study Carbohydrate Mediated Interactions"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Laurence Mulard (INSTITUT PASTEUR, France)
"Tuning Synthetic Glycan Haptens Toward a Broad Coverage Shigella Conjugate Vaccine"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Short Talk Selected from Poster Abstracts
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Biao Yu (Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China)
"A Personal Account on the Total Synthesis for Structural Validation of Natural Glycans and Glycoconjugates"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Nicole Snyder (Davidson College, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Glycoimmunology and Vaccines
Discussion Leader: Steven Sucheck (The University of Toledo, United States)
7:30 pm - 7:55 pm
Zhongwu Guo (University of Florida, United States)
"Totally Synthetic Glycoconjugate Vaccines Against Cancer and Bacteria Using Lipid A Derivatives as Carrier Molecules"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
James Paulson (The Scripps Research Institute, United States)
"Siglecs as Glycoimmune Checkpoints for Suppressing Unwanted Immune Responses"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Short Talk Selected from Poster Abstracts
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Edward Ryan (Harvard University-Massachusetts General Hospital, United States)
"Immune Responses Targeting Bacterial O-Specific Polysaccharide During Enteric Infection, Lessons from Cholera"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Industrial Applications of Glycoscience
Discussion Leader: Jennifer Koviach-Cote (Bates College, United States)
9:00 am - 9:25 am
Muthiah (Mano) Manoharan (Alnylam Pharmaceuticals, United States)
"How Glycochemistry and Glycocojugates Made Successful Nucleic Acid Therapeutics Possible"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
John Magnani (GlycoMimetics, Inc., United States)
"Novel Glycomimetic Drugs in Clinical Trials for Cancer and Inflammatory Disease"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Short Talk Selected from Poster Abstracts
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Francesca Micoli (Gsk vaccines institute for global health, Italy)
"GMMA as Innovative Delivery System for Carbohydrates"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chemical Glycobiology
Discussion Leader: Lina Cui (University of Florida, United States)
7:30 pm - 7:55 pm
Stephen Withers (University of British Columbia, Canada)
"New Enzymes and New Mechanisms through Metagenomic Screening"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Linda Hsieh-Wilson (California Institute of Technology, United States)
"Decoding Glycosaminoglycans and Their Roles in Neuroplasticity"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Short Talk Selected from Poster Abstracts
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Hung-Wen Liu (University of Texas at Austin, United States)
"Studies of the Biosynthesis of the Adenosine-Based Antibiotics Herbididins"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Glycoanalysis and Glycomics
Discussion Leader: Joseph Barchi Jr. (National Cancer Institute, NIH, United States)
9:00 am - 9:25 am
Anne Dell (Imperial College London, United Kingdom)
"High Sensitivity N- and O-Glycomics: Insights into the Glycobiology of the Great Obstetrical Syndromes"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Jesus Jimenez-Barbero (CIC bioGUNE, Spain)
"Breaking the Limits in Understanding Glycan Recognition by NMR"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Maren Roman (Virginia Tech, United States)
"Glycoanalytics at the Interface of Glycomaterials and Glycobiology"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
Ten Feizi (Imperial College London, United Kingdom)
"Multifaceted Approaches to Unraveling Glycan Recognition Systems"
11:40 am - 11:50 am
Discussion
11:50 am - 12:15 pm
Lara Mahal (University of Alberta, Canada)
"Rethinking the Paradigm: New Roles for Non-Coding RNA in Controlling the Glycome"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Glycans and Therapeutics
Discussion Leader: Weiping Tang (University of Wisconsin-Madison, United States)
7:30 pm - 7:55 pm
Todd Lowary (Academia Sinica, Taiwan)
"Glycan Arrays, Diagnostics and Mycobacteriophages"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
Short Talk Selected from Poster Abstracts
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
David Vocadlo (Simon Fraser University, Canada)
"Chemical Biology Tools for Image-Based Quantification of Enzyme Activities Within Living Cells"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Hermen Overkleeft (Leiden Institute of Chemistry, Leiden University, The Netherlands)
"Activity-Based Glycosidase Profiling"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Enzymatic and Glycoconjugate Synthesis
Discussion Leader: Lai-Xi Wang (University of Maryland College Park, United States)
9:00 am - 9:25 am
Xi Chen (University of California, Davis, United States)
"Process and Glycosyltransferase Engineering for Chemoenzymatic Synthesis of Carbohydrates and Glycoconjugates"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Yasuhiro Kajihara (Osaka University, Japan)
"Glycans on Proteins"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Short Talk Selected from Poster Abstracts
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Jian Liu (University of North Carolina at Chapel Hill, United States)
"Development a LC-MS/MS Based Method to Analysis of Rare Heparan Sulfates Using Synthetic Isotopically Labeled Calibrants"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Glycans in Host-Microbe Interactions
Discussion Leader: Danielle Dube (Bowdoin College, United States)
7:30 pm - 7:55 pm
Willie Vann (U.S. Food and Drug Administration, United States)
"Capsules of Pathogenic Bacteria: Synthesis by Polysaccharide Polymerases"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
Short Talk Selected from Poster Abstracts
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
Short Talk Selected from Poster Abstracts
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Short Talk Selected from Poster Abstracts
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Gerald Pier (Harvard Medical School, United States)
"Role of the Conserved Microbial Surface Polysaccharide, Poly-N-acetyl Glucosamine (PNAG) in pPathogenesis of Microbiota-Driven Human Diseases"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure