Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
New Concepts in Arrhythmia Susceptibility
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
"Macrophages in Cardiac Conduction and Arrhythmia"
8:10 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"Autoimmune Cardiac Channelopathy"
8:45 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Inflammasome Signaling Promotes Atrial Fibrillation"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Emerging Approaches for Cell and Tissue Imaging
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Three-Dimensional Electron Tomography of Cardiomyocytes"
9:25 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Real-Time Optical Manipulation of Cardiac Conduction in Intact Hearts"
10:00 am - 10:15 am
Discussion
10:15 am - 10:25 am
"3D Reconstructions of Non-Myocytes in Optically Cleared Hearts Reveal Similar Morphology of Fibroblasts and Resident Macrophages "
10:25 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Observing Cardiac Dynamics in 4D and 5D with Volumetric Multi-Spectral Optoacoustic Tomography"
11:15 am - 11:30 am
Discussion
11:30 am - 11:50 am
"From Images to Information: Novel Tools for Modeling Experimental Insights from hiPSC and Derived Cells"
11:50 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Listening to Voltage in the Heart to Disentangle Mechanisms of Arrhythmias"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Advances in Cardiac Ion Channel Structure
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Macromolecular Organization of Cardiac Sodium Channels"
6:25 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Dynamic Structure of the IKs Channel Voltage Sensor Domain"
7:00 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
"Relating Ion Channel Structural Dynamics to Physiological Function"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Unraveling the Mechanisms of the Obese Heart: Role for Potassium Channels "
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Transcriptional, Translational and Epigenetic Regulation of Heart Rhythm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Co-Translational Regulation of Cardiac Ion Channels"
9:25 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Super-Enhancers and Transcriptional Regulation of Cardiac Electrical Activity"
10:00 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Transcriptome Analysis of an Atrial Tachy-Paced Pig Model Using Bulk and Single Cell RNA-Sequencing"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Notch-Mediated Transcriptional and Epigenetic Regulation of Cardiac Ion Channels"
11:20 am - 11:35 am
Discussion
11:35 am - 11:55 am
"ETV1 Induces Atrial Remodeling and Arrhythmia"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Dietary Saturated Fat Promotes Arrhythmia by Activating NADPH Oxidase 2"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Neuromodulation of Heart Rhythm
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Transcriptional and Signal Transduction Underlying Neuromodulation of Heart Rhythm"
6:25 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Sympathetic Modulation of Cardiac Electrophysiology"
7:00 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
"Autonomic Neuromodulation as Anti-Arrhythmic Therapy"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Functional Co-Culture of Sympathetic Neurons and Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Decrypting Genetic Variants of Unknown Significance
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Genome Editing of Human iPS Cells to Investigate Cardiac Ion Channel Variants"
9:25 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Automated Electrophysiology for Functional Evaluation of KCNQ1 Variants"
10:00 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 10:55 am
"Deep Mutational Scanning of SCN5A"
10:55 am - 11:05 am
Discussion
11:05 am - 11:20 am
"Optical Mapping of Cardiac Action Potentials in Zebrafish to Assess Genetic Variants"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Electrical Heterogeneity in Adult Zebrafish Hearts Under Normal Conditions and During Proarrhythmic Oxidative Stress "
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Optogenetic Modulation of Central and Intracardiac Neural Pathways Controlling Heart Rhythm in Zebrafish in Development, Ageing and Disease"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Prediction of Arrhythmia Risk
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Prediction of Drug-Induced Arrhythmia Using Machine Learning"
6:25 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Computational Approaches to Predict Cardiac Arrhythmia Susceptibility"
7:00 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
"Predicting Proarrhythmia Using Cardiomyocytes Derived from iPS Cells"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Novel Single Cell and High-Throughput Phenotypical Platform to Study Atrial Rhythm in hiPSCs"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
New Approaches to Antiarrhythmic Therapy
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Novel Approaches to Discover Drug Targets for Atrial Fibrillation"
9:25 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Identifying Atrial Fibrillation Genes and Mechanisms Using a Multi-Model Systems Approach"
10:00 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Engineered Heart Slice Preparation for Drug Studies and Disease Modeling"
10:25 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Gene Therapy for Atrial Fibrillation"
11:25 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Noninvasive Cardiac Radiation Therapy for Ablation of Ventricular Tachycardia"
12:00 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"DG-GUI: A Novel Interactive Tool to Analyze Atrial Tachycardia"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Mechanistically-Guided Treatment of Arrhythmias
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Drug Repurposing for Long-QT Syndrome"
6:25 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Short-Term Variability of Repolarization for Prediction and Prevention of Ventricular Arrhythmia"
7:00 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Fully Implantable Battery-Free Pacemakers for Optoelectric Stimulation of the Rodent Heart"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Virtual-Heart Technology Guides Ablation of Infarct-Related Ventricular Tachycardia"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure