Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
New Aspects of Cardiac Regeneration, Repair and Development
7:40 pm - 8:00 pm
"Live Analysis of Mammalian Heart Formation"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Pluripotent Stem Cell-Derived Cardiac Cells: Heterogeneity and Maturation"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Cardiac Regeneration by Side Population Cells"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Electrotaxis of Cardiac Progenitors and Fibroblasts"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Pathophysiological Signal Transduction in Myocardial Remodeling
9:00 am - 9:20 am
"Deciphering the Cardiac Fibroblast Signaling Network"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"G Protein-Coupled Receptor Kinases and Beta-Adrenergic Signaling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Regulation of Cardiac Hypertrophy by the A-Kinase Anchoring Protein mAKAP"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Multifaceted Roles of PI3K in the Heart"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Advances in Ultrasound Technology for Precision Medicine"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Regulation of the Heart by Non-Coding RNAs and Chromatin
7:30 pm - 7:50 pm
"Exosomes and Epitranscriptome in Cardiac Regeneration"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Drugging Transcription in Heart Failure"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Long Non-Coding RNAs in Cardiovascular Medicine"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Long Non-Coding RNAs in Cardiac Aging"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metabolic and Mitochondrial Dysfunction in Cardiovascular Disease
9:00 am - 9:20 am
"The Molecular Mechanism of Lipotoxicity in Response to High Fat Diet Feeding"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Mitochondrial Ion Transport Mechanisms"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Impaired Mitochondrial Function in Heart Failure"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:20 am
"Myocardial Insulin Signaling and Heart Failure"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Evolution of CaMKII Oxidation: Implications for Physiology and Disease"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"MCUB Regulates the Molecular Composition of the Mitochondrial calcium Uniporter Channel to Limit Mitochondrial Calcium Overload"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Single-Nucleus Transcriptomic Survey of Cell Diversity and Functional Maturation in the Postnatal Mammalian Hearts"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Role of Non-Myocytes in Cardiac Regulation
7:30 pm - 7:50 pm
"Multi-Cellular Cross-Talk Regulating Cardiac Function"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Inflammation Inhibits Bone Marrow Progenitor Cell Exosomes Cargo and Their Myocardial Repair Function"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Neuronal Regulation of Cardiac Excitability: Role of Cyclic Nucleotide Coupled Phosphodiesterases"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Fibroblasts, Collagen and Transverse Tubules of Ventricular Myocytes"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Aberrant Ca Signaling and Arrhythmia Mechanisms
9:00 am - 9:20 am
"Cellular Origin of Ventricular Ectopy"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Arrhythmogenic SR Ca-Release Mechanisms in Heart Failure"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Plakophilin-2 in the Regulation of Ca and Rhythm"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Novel Regulatory Mechanisms in Mitochondrial Calcium Uptake"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"FGF13 as a Na Channel Auxilliary Subunit"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"MANF, a Structurally Unique Redox-Sensitive Chaperone, Restores ER-Protein Folding and Mitigates Ischemia/Reperfusion Damage in the Heart"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Missense Mutation in Plakophilin-2 Mediates Reduction in Sodium Currents in ARVC hiPSC-CM"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Regulation of and by Myofilaments
7:30 pm - 7:50 pm
"Biomechanical Phenotypes of Cardiomyocytes Derived from Hypertrophic Cardiomyopathy Patient iPSCs"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"The Actin 'A-Triad's' Role in Contractile Regulation in Health and Disease"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"A Visual and Omics Approach to Sarcomere Dynamics"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Suppressing Detyrosinated Microtubules Improves Myocyte Function in Human Heart Failure"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Exercise Promotes a Cardioprotective Gene Program in Resident Cardiac Fibroblasts"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Technologies and Therapies
9:00 am - 9:20 am
"Dynamics of Chromatin Structure in Heart Failure"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Insights into Ryanodine Receptor Ligand Binding and Gating Using Cryo-EM and Geometric Machine Learning"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Cutting and Pasting Myofilament Proteins with Spy-C Mice"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Future Directions in Proteomics: Proteome Dynamics and Novel Isoform Detection"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Gene Therapy for Myofilament Disorders"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"A Two-Hit Model for Cardiac Myocyte Proliferation: Relieving Epigenetic Blockade and Activating Mitogenic Pathways"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Discovery of MOXI, a Mitochondrial Micropeptide that Regulates Fatty Acid Beta-Oxidation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Translating Mechanisms to Therapies
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:20 pm
"Broadening the Therapeutic Potential of a Protein Kinase G Interactome"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
"The 5 Thrombospondin Genes Generate an Intracellular Distribution Network"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure