1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Improving Technology and Its Application
Lili Wang (Vanderbilt University Medical Center, United States) and Jessica Caldwell (University of California Davis, United States)
3:45 pm - 3:55 pm
Benjamin Keepers (University of North Carolina School of Medicine, United States) "Cross-lineage Potential of Ascl1 Uncovered by Comparing Diverse Reprogramming Regulatomes"
3:55 pm - 4:00 pm
4:00 pm - 4:10 pm
Fiona Wong (University of Arizona, United States) "Hypertrophic Cardiomyopathy Mutations in MyBP-C Detected to Enhance Myosin Binding"
4:10 pm - 4:15 pm
4:15 pm - 4:30 pm
4:30 pm - 6:00 pm
6:00 pm - 7:00 pm
7:30 pm - 9:30 pm
Advancing Therapeutic Potential
Eric Schoger (University Medical Center Goettingen, Germany) and Malina Ivey (University of Cincinnati, United States)
7:30 pm - 7:40 pm
Niels Pietsch (University Medical Center Hamburg-Eppendorf, Germany) "Tubulin Tyrosine Ligase Gene Therapy Ameliorates Heart Function and Increases Diastolic Compliance in a Mouse Model of Hypertrophic Cardiomyopathy"
7:40 pm - 7:45 pm
7:45 pm - 7:55 pm
Devon Guerrelli (Children's National Hospital, United States) "Off-Label Drugs in Cardiology: Optimizing Age- and Disease-Appropriate Therapies Using Preclinical Models"
7:55 pm - 8:00 pm
8:00 pm - 8:10 pm
Perwez Alam (University of Cincinnati, United States) "Cardiac Rejuvenation: a Promising Approach to Protect the Injured Adult Heart."
8:10 pm - 8:15 pm
8:15 pm - 9:00 pm
Johannes Backs (Heidelberg University, Germany) "Targeting Histone Deacetylases in Heart Disease"
9:00 pm - 9:15 pm
9:15 pm - 9:30 pm
7:30 am - 8:30 am
9:00 am - 11:00 am
Cardiomyocyte Non-Cardiomyocyte Communication
Lay Ping Ong (Wellcome-MRC Stem Cell Institute, University of Cambridge, United Kingdom) and Darrian Bugg (University of Washington, United States)
9:00 am - 9:10 am
Mukti Chowkwale (University of Virginia, United States) "Intercellular Model Predicts Mechanisms of Inflammation-Fibrosis Coupling After Myocardial Infarction"
9:10 am - 9:15 am
9:15 am - 9:25 am
Mary Rowland (The University of Alabama, United States) "Differential Effects of ATF6 Proteins on Skin Wound Healing and Potential Contributions to Cardiomyocyte Repair"
9:25 am - 9:30 am
9:30 am - 9:40 am
Ellen Malovrh (University Hospital Heidelberg, Germany) "Microprotein SPAR Regulates Cardiac Remodelling After Ischemia-Reperfusion Injury"
9:40 am - 9:45 am
9:45 am - 9:55 am
Rich (Gang) Li (Texas Heart Institute/Baylor College of Medicine, United States) "Spatial Transcriptomics Reveal a Colocalized Cellular Triad Required for Heart Renewal"
9:55 am - 10:00 am
10:00 am - 11:00 am
Jonathan Davis (The Ohio State University, United States)
Catherine Makarewich (Cincinnati Children's Hospital Medical Center, United States)
Shirin Doroudgar (The University of Arizona College of Medicine Phoenix, United States)
Rebecca Slater (Tenaya Therapeutics, United States)
11:00 am - 12:30 pm
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
1:30 pm - 2:30 pm
Novel Concepts and Mechanisms in Cardiovascular Biology
Matthew Caporizzo (The University of Vermont, United States) and Jeanette Einspahr (Temple University, United States)
1:30 pm - 1:40 pm
Sienna Pyle (University of Pennsylvania, United States) "The Role of Telomeric Binding Factor 2 in Cardiac Development and Disease"
1:40 pm - 1:45 pm
1:45 pm - 1:55 pm
Yifan Wang (UCLA, United States) "Protein Translation Regulation in Cardiac Hypertrophy and Remodeling"
1:55 pm - 2:00 pm
2:00 pm - 2:10 pm
Kobina Essandoh (University of Michigan, United States) "Palmitoylation-Dependent Regulation of Rab3gap1, Cardiomyocyte Exocytosis, and Atrial Natriuretic Peptide Secretion"
2:10 pm - 2:15 pm
2:15 pm - 2:25 pm
Sean Cleary (Loyola University Chicago, United States) "Deletion of Arginine 14 Increases Phospholamban Oligomerization and Disrupts the Cardiac Force-Frequency Relationship"
2:25 pm - 2:30 pm
2:30 pm - 3:00 pm
Complete the GRS Evaluation Forms; Election of Future Chair(s)