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Cartilage Biology and Pathology

Gordon Research Conference

Cartilage Biology, Structure and Function: From Development to Regeneration

March 19 - 24, 2023

Chairs Farshid Guilak and Frank Zaucke

Vice Chairs Rosa Serra and Gerjo J. Van Osch

Contact Chairs

Renaissance Tuscany Il Ciocco

Via Giovanni Pascoli

Lucca (Barga), LU, Italy

Venue and Travel Information

Conference Description

The Cartilage Biology and Pathology GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

The GRC on Cartilage Biology and Pathology covers a broad range of topics and new technologies as cartilage is not only the earliest skeletal tissue that supports skeletal development from embryos to adulthood, but also serves an essential skeletal component of a functional adult skeletal system. In this regard, diseases that result in cartilage malformation or degeneration significantly affect the lifespan and quality of life of a large part of the population. The GRC will highlight recent advances and challenges in understanding cartilage biology and diseases. Established scientists and talented new investigators will report and discuss their most recent exciting findings according to this theme and will provide insights into the remaining challenges towards understanding the various aspects of cartilage biology, disease, and translational approaches. We expect the 2023 GRC on Cartilage Biology and Pathology to empower researchers across disciplines to make significant progress towards understanding cartilage biology and improving human health.

Related Meeting

This GRC will be held in conjunction with the "Cartilage Biology and Pathology" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Cartilage Development and Regeneration Discussion Leader: Terence Capellini (Harvard University, United States)
7:40 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:05 pm	Deneen Wellik (University of Wisconsin-Madison, United States) "Loss of Hox11 Function Results in Disrupted Osteochondral Differentiation in Response to Fracture"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 8:35 pm	Christine Hartmann (University of Münster, Germany) "Insights Into Bone Marrow Cavity Formation"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	Aris Economides (Regeneron Pharmaceuticals, Inc., United States) "Skeletal Patterning Defects in Fibrodysplasia Ossificans Progressiva (FOP) are Dependent on Activation of FOP-Mutant ACVR1 by Activin A"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	Fadia Kamal (Penn State College of Medicine, United States) "GRK2: A Novel Regulator of Endochondral Ossification and Postnatal Skeletal Development"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	Véronique Lefebvre (Children's Hospital of Philadelphia, United States) "Chondrogenic Roles and Properties of SOX8"
9:25 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Epigenetics and Non-Coding RNAs Discussion Leader: Louise Reynard (Newcastle University Biosciences Institute, United Kingdom)
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	Yolande Ramos (Leiden University Medical Center, The Netherlands) "Leveraging Epigenetics in OA: Opportunities to Bridge the Translational Gap"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	Audrey McAlinden (Washington University, United States) "Targeting MicroRNAs to Treat Orthopaedic Conditions: Lessons from Limb Development"
9:55 am - 10:05 am	Discussion
10:05 am - 10:15 am	Adam Farrier (Newcastle University, United Kingdom) "TRAF3IP2 Perturbation in Human Articular Chondrocytes Reverses IL17 Induced OA-like Transcriptional Changes"
10:15 am - 10:20 am	Discussion
10:20 am - 10:30 am	Sade Clayton (Washington University in St. Louis, United States) "Multi-modal Transcriptomic Analyses of the Mouse Intervertebral Disc Following Injury Reveals a Temporally Distinct Cascade of Infiltrating Immune Cells"
10:30 am - 10:35 am	Discussion
10:35 am - 11:05 am	Coffee Break
11:05 am - 11:15 am	Terence Capellini (Harvard University, United States) "Uncovering the Transcriptomic, Epigenomic, and Spatial Profiles of the Developing Human Pelvic Girdle at a Single Cell Level"
11:15 am - 11:20 am	Discussion
11:20 am - 11:30 am	Divya Venkatasubramanian (Harvard University, Boston Children's Hospital, United States) "Gene Regulatory Networks Governing Human Articular and Growth Plate Chondrocyte Development"
11:30 am - 11:35 am	Discussion
11:35 am - 11:45 am	Sarah Rice (Newcastle University, United Kingdom) "Collagen-Modifying Enzyme COLGALT2 as a Mediator of Osteoarthritis Risk"
11:45 am - 11:50 am	Discussion
11:50 am - 12:10 pm	Francesco Dell'Accio (Queen Mary, University of London, United Kingdom) "From Regenerative Morphogenesis to Novel Therapeutics in Osteoarthritis"
12:10 pm - 12:20 pm	Discussion
12:20 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: Sarah Snelling (University of Oxford, United Kingdom), Rosa Serra (University of Alabama at Birmingham, United States) and Gerjo Van Osch (Erasmus MC, University Medical Center Rotterdam, The Netherlands)
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Extracellular Matrix Discussion Leader: Antonio Rossi (University of Pavia - Department of Molecular Medicine, Italy)
6:00 pm - 6:20 pm	Bent Brachvogel (University of Cologne, Germany) "Metabolism, Skeletal Development and Extracellular Matrix Homeostasis"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:40 pm	Blandine Poulet (University of Liverpool, United Kingdom) "Effects of Fibrillin-1 Deficiency on Osteoarthritis Development"
6:40 pm - 6:45 pm	Discussion
6:45 pm - 7:05 pm	Sarah Calve (University of Colorado Boulder, United States) "Visualization of ECM Dynamics During Limb Development"
7:05 pm - 7:15 pm	Discussion
7:15 pm - 7:25 pm	Dirk Hubmacher (Icahn School of Medicine at Mount Sinai, United States) "ADAMTS10 and ADAMTS17 Cooperate in Regulating Growth Plate Activity Through Extracellular Matrix Modulation Independent of their Proteolytic Activities"
7:25 pm - 7:30 pm	Discussion
7:30 pm - 7:50 pm	Jos Malda (UMC Utrecht, The Netherlands) "Collagen Structures: What Can We Learn From Other Species?"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Mechanobiology Discussion Leader: Louis DeFrate (Duke University, United States)
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	Andrew Pitsillides (Royal Veterinary College, United Kingdom) "Imaging Endochondral Interactions Across the Mineralised Phase"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	Angus Wann (Kennedy Institute, University of Oxford, United Kingdom) "Exploring Mechano-Tolerance, Mechano-plasticity and Matrix Remodelling by Targeting the Chondrocyte Ciliome"
9:55 am - 10:05 am	Discussion
10:05 am - 10:15 am	Sofia Gonzalez-Nolde (University of Delaware, United States) "F-actin Reorganization Regulates Cartilage Lubricating Protein, Proteoglycan-4 in Native Superficial Zone Chondrocytes"
10:15 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:10 am	Niamh Nowlan (University College Dublin, Ireland) "Biology and Mechanobiology of Cartilage Development"
11:10 am - 11:20 am	Discussion
11:20 am - 11:40 am	Ronald June (Montana State University, United States) "Mechanotransduction and Metabolism of Articular Chondrocytes"
11:40 am - 11:50 am	Discussion
11:50 am - 12:00 pm	Qing-Jun Meng (University of Manchester, United Kingdom) "Daily Mechanical Loading and Osmotic Cycles Reset the Circadian Clocks in Cartilage and Intervertebral Discs"
12:00 pm - 12:05 pm	Discussion
12:05 pm - 12:15 pm	Joanna Sherwood (University Hospital Münster, Germany) "Transient Receptor Potential Channel 1 (TRPC1) Links Intracellular Calcium Signaling to Cellular Senescence and is Involved in Osteoarthritis Development"
12:15 pm - 12:20 pm	Discussion
12:20 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Biomechanics and Bioengineering Discussion Leader: Corey Neu (University of Colorado Boulder, United States)
6:00 pm - 6:20 pm	Gerard Ateshian (Columbia University, United States) "How Stress Mediates Cartilage Wear and the Progression of Tissue Degeneration"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:50 pm	Suzanne Maher (Hospital for Special Surgery, United States) "Mechanical Phenotyping of Knees: Where we Stand Makes a Difference"
6:50 pm - 7:00 pm	Discussion
7:00 pm - 7:10 pm	Daniela Mählich (German Sport University Cologne, Germany) "Plastin-3 Contributes to Mechanosensing in Articular Cartilage"
7:10 pm - 7:15 pm	Discussion
7:15 pm - 7:35 pm	Markus Wimmer (Rush University Medical Center, United States) "The Ionic Phase in Cartilage and its Influence on Tissue Tribology"
7:35 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	Katherine Arnold (Mayo Clinic, United States) "Phlpp1 and Articular Cartilage Tissue Quality in Osteoarthritis"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Stem Cells, Tissue Engineering, and Differentiation Discussion Leader: Brian Johnstone (Oregon Health & Science University, United States)
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	Rhima Coleman (University of Michigan, United States) "Anti-Hypertrophic and Anti-Inflammatory Effects of Autonomous RUNX2 Suppression in Engineered Cartilage"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	Francis Berenbaum (Sorbonne University, France) "Glucagon-like Peptide-1 Analogues: Metabolic Roles and Beyond"
9:55 am - 10:05 am	Discussion
10:05 am - 10:15 am	Suzanne Eldridge (William Harvey Research Institute, United Kingdom) "Disease Modification and Symptom Relief in Osteoarthritis Using a Mutated GCP-2/CXCL6 Chemokine"
10:15 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:10 am	Solvig Diederichs (Heidelberg University Hospital, Germany) "Untangling the Signaling Pathways that Direct Chondral Versus Endochondral Cell Differentiation"
11:10 am - 11:20 am	Discussion
11:20 am - 11:40 am	Denis Evseenko (USC, United States) "Inhibition of a Signaling Modality Within Gp130 Receptor Enhances Tissue Regeneration and Mitigates Osteoarthritis"
11:40 am - 11:50 am	Discussion
11:50 am - 12:00 pm	Roberto Narcisi (Erasmus MC, The Netherlands) "Impact of Cellular Senescence on Stem Cells Chondrogenic Differentiation"
12:00 pm - 12:05 pm	Discussion
12:05 pm - 12:15 pm	Dana Trompet (Gothenburg University, Sweden) "Local and Transient Stimulation of Skeletal Stem Cells in the Growth Plate Causes Leg Length Discrepancy"
12:15 pm - 12:20 pm	Discussion
12:20 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Osteoarthritis Discussion Leader: Anne-Marie Malfait (Rush University Medical Center, United States)
6:00 pm - 6:20 pm	Carla Scanzello (University of Pennsylvanit, United States) "The Role of Pattern-Recognition in Osteoarthritis Pathology and Joint Pain"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:40 pm	MONA Dvir-Ginzberg (Hebrew University of Jerusalem, Israel) "Assessing the Role of SIRT1 Cleavage in OA Pathogenesis"
6:40 pm - 6:45 pm	Discussion
6:45 pm - 6:55 pm	Magdalena Kaneva (William Harvey Research Institute, QMUL, United Kingdom) "Repurposing Alpha-1-Antitrypsin as a Treatment of Osteoarthritis"
6:55 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	Eleftheria Zeggini (Helmholtz Munich, Germany) "Translational Genomics of Osteoarthritis"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:50 pm	Mohit Kapoor (Schroeder Arthritis Institute, University Health Network, Canada) "Multi-Omic Profiling in Osteoarthritis"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Rare Diseases, Disease Modeling and Aging Discussion Leader: Uwe Kornak (University Medical Center Göttingen, Germany)
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	Shireen Lamande (Murdoch Children's Research Institute, Australia) "Modelling Skeletal Disorders using Human Induced Pluripotent Stem Cells"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	Katarzyna Pirog (Newcastle University, United Kingdom) "Dissecting the Role of Kif22 in Skeletal Development and Health"
9:55 am - 10:05 am	Discussion
10:05 am - 10:15 am	Alice Stephan (University of Cologne, Germany) "Homozygous Kdelr2-Mutant Mice Display Defects in Endochondral and Intramembranous Bone Formation"
10:15 am - 10:20 am	Discussion
10:20 am - 10:30 am	Alessandra Leone (Università degli Studi di Pavia; Istituto Universitario di Studi Superiori (IUSS), Pavia, Italy) "Calcium-Activated Nucleotidase 1 Impairment Affects Proteoglycan Synthesis and Cell Homeostasis"
10:30 am - 10:35 am	Discussion
10:35 am - 11:05 am	Coffee Break
11:05 am - 11:25 am	Brian Diekman (Univ North Carolina / NC State, United States) "DNA Damage and Cellular Senescence in Osteoarthritis Pathophysiology"
11:25 am - 11:35 am	Discussion
11:35 am - 11:55 am	Christopher Little (University of Sydney, Australia) "Inflammation and Immunobiology of Joint Injury and Osteoarthritis Risk"
11:55 am - 12:05 pm	Discussion
12:05 pm - 12:15 pm	Danielle Rux (Children's Hospital of Philadelphia, United States) "Superficial Zone Cell Death in Adult Mouse Joints Leads to Early Onset Osteoarthritic Progression"
12:15 pm - 12:20 pm	Discussion
12:20 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Cartilaginous and Joint Tissues Discussion Leader: Susanne Graessel (University of Regensburg, Germany)
6:00 pm - 6:20 pm	Devina Purmessur (Walter) (The Ohio State University, United States) "Non-viral Gene Delivery of Development Factors to Treat Discogenic Back Pain"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:50 pm	Martin Englund (Lund University, Sweden) "Why Ultrastructure of Extracellular Matrix of Cartilage Matters"
6:50 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	Danny Chan (The University of Hong Kong, Hong Kong SAR China) "CDO-Associated Apoptosis in Synovial Joint Formation"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:40 pm	Chia-Lung Wu (University of Rochester School of Medicine and Dentistry -, United States) "Integrated scRNA-seq and Spatial Transcriptomics Analysis Uncovers Distinct Cellular Populations and Transcriptomes in Human Hip Synovium Between Patients With FAI and OA"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	Arin Oestreich (Washington University School of Medicine Department of Orthopedic Surgery, United States) "Maternal Transgenic Conversion of Omega-6 to Omega-3 Fatty Acids Enhances Fetal Growth and Mitigates Adult Offspring Pain Behavior in an Injury-induced Osteoarthritis Model"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Research reported in this publication was supported by the National Institute Of Arthritis And Musculoskeletal And Skin Diseases of the National Institutes of Health under Award Number R13AR082210. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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