Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Cartilage Development and Regeneration
Discussion Leader: Terence Capellini (Harvard University, United States)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Deneen Wellik (University of Wisconsin-Madison, United States)
"Loss of Hox Function Leads to Failure in Osteochondral Differentiation in Response to Fracture"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Christine Hartmann (University of Münster, Germany)
"Insights Into Bone Marrow Cavity Formation"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epigenetics and Non-Coding RNAs
Discussion Leader: Louise Reynard (Newcastle University Biosciences Institute, United Kingdom)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Yolande Ramos (Leiden University Medical Center, The Netherlands)
"Leveraging Epigenetics in OA; Opportunities to Bridge the Translational Gap"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Audrey McAlinden (Washington University, United States)
"MicroRNA Regulation of Skeletal Cell Function and Fate"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Short Talk Selected from Poster Abstracts
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Short Talk Selected from Poster Abstracts
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
Eleftheria Zeggini (Helmholtz Munich, Germany)
"Translational Genomics of Osteoarthritis"
11:25 am - 11:35 am
Discussion
11:35 am - 11:45 am
Short Talk Selected from Poster Abstracts
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Short Talk Selected from Poster Abstracts
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Sarah Snelling (University of Oxford, United Kingdom), Rosa Serra (University of Alabama at Birmingham, United States) and Gerjo Van Osch (Erasmus MC, University Medical Center Rotterdam, The Netherlands)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Extracellular Matrix
Discussion Leader: Antonio Rossi (University of Pavia - Department of Molecular Medicine, Italy)
6:00 pm - 6:20 pm
Bent Brachvogel (University of Cologne, Germany)
"Metabolism, Skeletal Development and Extracellular Matrix Homeostasis"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Sarah Calve (University of Colorado Boulder, United States)
"Visualization of ECM Dynamics During Limb Development"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Francis Berenbaum (Sorbonne University, France)
"Glucagon-like Peptide-1 Analogues: Metabolic Roles and Beyond"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Short Talk Selected from Poster Abstracts
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Short Talk Selected from Poster Abstracts
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Mechanobiology
Discussion Leader: Tamara Alliston (UCSF, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Andrew Pitsillides (Royal Veterinary College, United Kingdom)
"Imaging Endochondral Interactions Across the Mineralised Phase"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Angus Wann (Kennedy Institute, University of Oxford, United Kingdom)
"Exploring Mechano-tolerance, Mechano-plasticity and Matrix Remodelling by Targeting the Chondrocyte Ciliome"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Short Talk Selected from Poster Abstracts
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Niamh Nowlan (University College Dublin, Ireland)
"Biology and Mechanobiology of Cartilage Development"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Ronald June (Montana State University, United States)
"Mechanotransduction and Metabolism of Articular Chondrocytes"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Short Talk Selected from Poster Abstracts
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Biomechanics and Bioengineering
Discussion Leader: Corey Neu (University of Colorado Boulder, United States)
6:00 pm - 6:10 pm
Short Talk Selected from Poster Abstracts
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:25 pm
Short Talk Selected from Poster Abstracts
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Gerard Ateshian (Columbia University, United States)
"How Stress Mediates Cartilage Wear and the Progression of Tissue Degeneration"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Suzanne Maher (Hospital for Special Surgery, United States)
"Mechanical Phenotyping of Knees: Where we Stand Makes a Difference"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Markus Wimmer (Rush University Medical Center, United States)
"The Ionic Phase in Cartilage and its Influence on Tissue Tribology"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stem Cells and Tissue Engineering
Discussion Leader: Brian Johnstone (Oregon Health & Science University, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Rhima Coleman (University of Michigan, United States)
"Anti-hypertrophic and Anti-inflammatory Effects of Autonomous RUNX2 Suppression in Engineered Cartilage"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Jos Malda (University of Twente/ Isotis S.A., The Netherlands)
"Collagen Structures – What Can We Learn From Other Species?"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Short Talk Selected from Poster Abstracts
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Solvig Diederichs (Heidelberg University Hospital, Germany)
"Untangling the Signaling Pathways that Direct Chondral Versus Endochondral Cell Differentiation"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Denis Evseenko (USC, United States)
"Inhibition of a Signaling Modality Within Gp130 Receptor Enhances Tissue Regeneration and Mitigates Osteoarthritis"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Short Talk Selected from Poster Abstracts
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Osteoarthritis
Discussion Leader: Anne-Marie Malfait (Rush University Medical Center, United States)
6:00 pm - 6:20 pm
Carla Scanzello (University of Pennsylvania, United States)
"The Role of Pattern-recognition in Osteoarthritis Pathology and Joint Pain"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Short Talk Selected from Poster Abstracts
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Francesco Dell'Accio (Queen Mary, University of London, United Kingdom)
"From Regenerative Morphogenesis to Novel Therapeutics in Osteoarthritis"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Short Talk Selected from Poster Abstracts
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Mohit Kapoor (Schroeder Arthritis Institute, University Health Network, Canada)
"Multi-Omic Profiling in Osteoarthritis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Rare Diseases, Disease Modeling and Aging
Discussion Leader: Uwe Kornak (University Medical Center Göttingen, Germany)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:10 am
Discussion
9:10 am - 9:30 am
Brian Diekman (Univ North Carolina / NC State, United States)
"DNA Damage and Cellular Senescence in Osteoarthritis Pathophysiology"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Shireen Lamande (Murdoch Children's Research Institute, Australia)
"Modelling Skeletal Disorders using Human Induced Pluripotent Stem Cells"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Short Talk Selected from Poster Abstracts
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Christopher Little (University of Sydney, Australia)
"Inflammation and Immunobiology of Joint Injury and Osteoarthritis Risk"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
Katarzyna Pirog (Newcastle University, United Kingdom)
"Dissecting the Role of Kif22 in Skeletal Development and Health"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Short Talk Selected from Poster Abstracts
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:35 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cartilaginous and Joint Tissues
Discussion Leader: Susanne Graessel (University of Regensburg, Germany)
6:00 pm - 6:20 pm
Devina Purmessur (Walter) (The Ohio State University, United States)
"Non-viral Gene Delivery of Development Factors to Treat Discogenic Back Pain"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Short Talk Selected from Poster Abstracts
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Martin Englund (Lund University, Sweden)
"Why Ultrastructure of Extracellular Matrix of Cartilage Matters"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Short Talk Selected from Poster Abstracts
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Danny Chan (The University of Hong Kong, Hong Kong SAR China)
"The Role of Synovial Cells in Development"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure