Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Keynote Session: Gene Regulation in Cartilage Biology
Discussion Leader: Sade Clayton (Washington University in St. Louis, United States)
3:15 pm - 3:35 pm
Terence Capellini (Harvard University, United States)
"Regulation of Human Skeletal Development"
3:35 pm - 3:45 pm
Discussion
3:45 pm - 3:55 pm
Astrid De Roover (KU Leuven, Belgium)
"Peroxisomal Lipid Metabolism Controls H3K79 Methylation in Articular Cartilage and Osteoarthritis"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Mechanisms of Cartilage Disease
Discussion Leader: Lance Murphy (University of Pennsylvania, United States)
5:30 pm - 5:35 pm
Introduction by Discussion Leader
5:35 pm - 5:45 pm
Kevin Burt (University of Pennsylvania, United States)
"CD14 Deficiency Reduces Leukocyte Infiltration and Modulates Chemokine Expression in the Synovium and Fat Pad after Injury in Mice"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:00 pm
Satanik Mukherjee (KUL, Belgium)
"Multi-scale Modeling to Elucidate the Role of Mechanics in Cartilage Degeneration and Regeneration"
6:00 pm - 6:05 pm
Discussion
6:05 pm - 6:15 pm
Carmen Núñez-Carro (Instituto de Investigación Biomédica de A Coruña (INIBIC), Spain)
"Elucidating the Post-translational Modifications Profile of Histones in Osteoarthritic Cartilage"
6:15 pm - 6:20 pm
Discussion
6:20 pm - 6:30 pm
Alia Obeidat (Rush University Medical Center, United States)
"The Role of NGF Signaling in Joint Homeostasis, Neuronal Sprouting and Pain in Healthy and Osteoarthritic Murine Knee Joints: An Exploration"
6:30 pm - 6:35 pm
Discussion
6:35 pm - 6:45 pm
Jack Roberts (Newcastle University, United Kingdom)
"Molecular Analyses and Epigenetic Editing Reveal Specific WWP2 Isoforms as Effectors of OA Genetic Risk"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:00 pm
Nicole Schäfer (University Hospital Regensburg, Germany)
"a-MSH Modulates Senescence and Inflammatory State of Human Osteoarthritic Chondrocytes"
7:00 pm - 7:05 pm
Discussion
7:05 pm - 7:15 pm
Rebecca Sohn (Dr. Rolf M. Schwiete Research Unit for Osteoarthritis, Germany)
"Early OA Patients Exhibit an Autonomic Nervous System Dysfunction"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:30 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Cartilage Development and Regeneration
Discussion Leader: Alice Stephan (University of Cologne, Germany)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:15 am
Kelsey Elliott (University of Southern California, United States)
"A Multi-Omics Approach Reveals Early Joint Cartilage Development Integrates Ap-1 Signaling and Regional Factors"
9:15 am - 9:20 am
Discussion
9:20 am - 9:30 am
Ermina Hadzic (Western University, Canada)
"Anabolic Phenotype in Cartilage-Specific Mitogen-Inducible Gene-6 Knockout Mice is Independent of Transforming growth factor-ß"
9:30 am - 9:35 am
Discussion
9:35 am - 9:45 am
Lindsey Lammlin (University of Michigan, United States)
"Dual Deficiency of Thrombospondin-1 and -2 Causes Aberrant Intra-Articular Angiogenesis, Inflammation, and Ectopic Synovial Bone Formation"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
Stephen Gadomski (National Institutes of Health, United States)
"Time- and Cell-Specific Activation of BMP Signaling Restrains Chondrocyte Hypertrophy"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
Alexander Okamoto (Harvard University, United States)
"Cartilage Patterning of the Human Autopod Skeleton"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Michael Palmer (Marine Biological Laboratory, United States)
"Molecular Control of Chondrocyte Hypertrophy: An Evolutionary Approach"
10:30 am - 10:35 am
Discussion
10:35 am - 10:45 am
Rosanne Raftery (Boston Children's Hospital, United States)
"Stability and Regenerative Capacity of hPSC-Derived Articular Chondrocytes"
10:45 am - 10:50 am
Discussion
10:50 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Insights and Strategies for the Future of Cartilage Research
Discussion Leader: Clarissa Coveney (Harvard, United States)
1:30 pm - 1:35 pm
Introduction by Discussion Leader
1:35 pm - 1:55 pm
Sarah Snelling (University of Oxford, United Kingdom)
"Building Single-Cell Atlases of Musculoskeletal Tissues"
1:55 pm - 2:05 pm
Discussion
2:05 pm - 2:30 pm
Panel Discussion
Panel Discussion: Career Pathways in Musculoskeletal Research
David Wilkinson (University of Liverpool, United Kingdom)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes