Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: From Fundamental Biology to Novel Therapies
7:40 pm - 8:20 pm
"Defective Megakaryopoiesis in the Myeloproliferative Neoplasms"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
"Novel Insights into Glycans and Hematopoiesis"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:25 am
"Genomic Mechanisms Regulating Platelet Receptors for Collagen and Thrombin Signaling"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"In Search of a Safe Path to Thrombosis Prevention: The Discovery of Orally Active Small Molecule PAR4 Antagonists"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Kupffer Cells Clear Aged, Desialylated Platelets Through Collaboration Between Macrophage Galactose Lectin (MGL) and the Ashwell-Morell Receptor"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"GPIb-IX MSD Dynamics and/or Thrombocytopenia"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Platelet Survival and Clearance In Vivo "
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Desialylation and Apoptosis Are Related Events Leading to Platelet Clearance"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Redefining the Lineage: Effect of Environmental Factors on Megakaryocyte Development
7:30 pm - 7:55 pm
"The Cellular Microenvironment of Megakaryopoiesis During Development"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Clonal Stem Cell Heterogeneity and Megakaryocyte Bias in Native and Transplantation Hematopoiesis"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Advanced Imaging to Study Thrombopoiesis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Thyroid Hormones Induce Acute Platelet Production via a THR-Independent Mechanism Through aVb3, a Novel Pathway of Thrombopoiesis"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Engineering Advances in Platelet Production and Platelet-Based Drug Delivery
9:00 am - 9:25 am
"Platelet Generation from iPS Cells"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"New Approaches in 3D Bio-Modelling to Document Megakaryocyte Functional Regulation by Extracellular Matrix Structure and Composition"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"TREM-Like Transcript-1: A Novel Non-Conventional Regulator of Platelet and Megakaryocyte Function"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Platelet-Delivered Immunotherapies"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Bio-Inspired Functional Mimicry of Platelets for Hemostatic and Drug Delivery Nanomaterials"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Human Megakaryocytes Possess Intrinsic Anti-Viral Immunity Through Regulated Induction of IFITM3"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Disruptions in the Bone Marrow Niche
7:30 pm - 7:55 pm
"The Role of the Cell Cycle in Megakaryocyte Fate Decisions"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"New Findings in Bone Marrow Remodeling"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"G6b-B, Congenital Macrothrombocytopenia and Myelofibrosis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"scRNA-Seq Transcriptome Analysis of Native Megakaryocytes Identifies Significant Inflammatory, Metabolic and Mitochondrial Signatures Associated to Platelet Hyperreactivity in Aging and MPN"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Expanding the Horizon of Megakaryocyte and Platelet Biology
9:00 am - 9:25 am
"Platelets on the Move: Boosters of Innate Immunity"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Finding Genes in Genomes to Match with Platelet Disorders"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Soluble Glycoprotein V Is a Novel Antithrombotic Agent"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Platelet Biogenesis in the Lung Circulation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Megakaryocytes as Immune Cells"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"The VWF-GPIb Interaction Mediates Thrombo-Inflammation in Experimental Stroke via Recruitment of Monocytes, Neutrophils and T-Cells to the Brain"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:55 pm
"Rap1 Effectors for Integrin Activation in Platelets and Leukocytes"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Inherited Platelet Disorders: Characterization of Novel Variants and Phenotypic Correction by Gene Therapy"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Class II and III PI3Ks in Platelet Genesis, Thrombosis and Beyond"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Blocking of Integrin-Ga13 Interaction in Platelets or Leukocytes Protects Mice from Death in Severe Sepsis"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Interplay Between the Megakaryocyte Lineage and Inflammation
9:00 am - 9:25 am
"Regulating Thrombopoiesis to Limit Vascular Disease in Diabetes"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Role of CCL5 in Megakaryocyte Development, Maturation and Survival"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"NLRP3 Regulates Platelet Integrin aIIbb3 Outside-in Signaling, Hemostasis and Arterial Thrombosis Through IL-1"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Platelet-Neutrophil Interactions: Lessons from Heparin Induced Thrombocytopenia"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Understanding the Duality of Platelets in Inflammation: What's at Stake?"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"FcgRIIA Exacerbates Disease Pathogenesis and Platelet Activation in Systemic Lupus Erythematosus"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Single Cell Approaches to Study Megakaryocytes and Platelets
7:30 pm - 7:55 pm
"Building Proteins to Peek and Poke at GTPase Circuits In Vivo "
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"One Cell at at Time: Single Cell Approaches to Studying Normal and Malignant Megakaryopoiesis"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Mass Cytometry for Platelet and Megakaryocyte Characterization and Functional Analysis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"High Content Analysis of Megakaryocytes and Proplatelet Production via Supervised Machine-Learning"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure